Freeze Granulation is a wet granulation method where the powders, chemicals and binders are first mixed and dispersed in a solvent. In the next step the homogeneous slurry is pumped and sprayed through a nozzle to form droplets, which are sprayed into liquid nitrogen for instant freezing. In the final step the frozen granulate is moved to a freeze dryer where the solvent is sublimated leaving spherical, dust-free and homogeneous granules. The solvent could be water or organic solvents with a freezing point close to zero degree, like cyclohexane.
ECerS 2013 – Easy to clean – Third day at ECerS in Limoges, and today the keyword is “Easy to clean”! This morning we have had several discussions with researchers that have big problem cleaning their spray dryers for to aviod contamination of the material.
By using our Freeze Granulation technology, Lab-scale Granulator LS-2, it’s possible to granulate 10 unique slurries in one afternoon, including cleaning, and also avoiding contamination.
ECerS XIII – Universities and Institutes – Second day at ECerS in Limoges. We can see that research groups around the world show an increasing interest in Freeze Granulation as a powder processing tool of especially nanopowders, like carbon nanotubes. The reason being as Freeze Granulation offers an easy and practical method to handle fine nanopowders and to manufacture homogeneous granules which are optimal for pressing and sintering of different materials.
ECerS XIII – Granulation of Nanoparticles – During first day at the conference we have had interesting discussions on how Freeze Granulation can help to make homogeneous granules of, for example, Carbon Nanotubes (CNT).
ECerS XIII Conference – Limoges, France – Welcome to PowderPro’s stand No 1 at the exhibition at ECerS XIII Conference (European Ceramic Society) in Limoges, France from the 23rd to the 27th of June 2013. We look forward to meet customers, partners and new contacts for interesting discussions in our stand!
We plan to have our equipment available at a nearby lab for you to see the process of Freeze Granulation.
Synthetic diamond powder granulation by Freeze Granulation is today being used for to make homogeneous granules for diamond tools with long tool-life and optimal performance.
Freeze Granulation of thermally sensitive nanoparticles
By using Freeze Granulation, spray freeze drying (SFD), you can produce dry-powder aggregates of thermally sensitive nanoparticles. Dry powder inhaler (DPI) delivery of therapeutic nanoparticles requires the nanoparticles to be transformed into inhalable micro-scale aggregate structures (i.e. nano-aggregates). With Freeze Granulation you will be able to optimize the aerosolization efficiency of the nano-aggregates, while keeping the morphology, production yield, flowability, and aqueous reconstitution in the desirable range.
Freeze granulation, as opposed to spray drying, has been shown to produce protein particles with light and porous characteristics, which offered powders with superior aerosol performance due to favorable aerodynamic properties, suitable granulation technology for protein inhalation powders.
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