Category: Scientific papers

A Comprehensive Review of the Latest Trends in Spray Freeze Drying and Comparative Insights with Conventional Technologies Maria Ioannou Sartzi, Dimitrios Drettas, Marina Stramarkou, M. Krokida Abstract Spray freeze drying (SFD) represents an emerging drying technique designed to produce a wide range of pharmaceuticals, foods, and active components with high quality and enhanced stability due… Continue reading A Comprehensive Review of the Latest Trends in Spray Freeze Drying and Comparative Insights with Conventional Technologies

Sustainability assessment of cold chain-free biopharmaceuticals: life-cycle trade-offs, green chemistry challenges, and future directions Qiang Zhu, Yan-Yan Yu, Tian-Qing Liu, Yong-Mei Zhao Abstract Biologic therapeutics now dominate the pharmaceutical pipeline, bringing an increasing dependence on temperature-controlled supply chains that are costly, energy-intensive and vulnerable to climate disruption, particularly in low- and middle-income countries. Numerous technologies… Continue reading Sustainability assessment of cold chain-free biopharmaceuticals: life-cycle trade-offs, green chemistry challenges, and future directions

DRYING TECHNIQUE IMPACT ON LIPOSOMAL MICROPARTICLES: A COMPARATIVE STUDY OF FREEZE-DRIED AND SPRAY DRIED FORMULATION FOR LUNG DELIVERY Huner K. Omer Abstract The drying process plays a critical role in determining the physicochemical and aerosolization properties of pulmonary drug delivery systems. This study compares freeze-drying (FD) and spray-drying (SD) for the preparation of liposomal microparticles… Continue reading DRYING TECHNIQUE IMPACT ON LIPOSOMAL MICROPARTICLES: A COMPARATIVE STUDY OF FREEZE-DRIED AND SPRAY DRIED FORMULATION FOR LUNG DELIVERY

Stage-Specific Stability of Spray-Freeze-Dried Ovalbumin-Loaded Liposomes: Dissecting the Impact of Atomization, Freezing, and Drying of Cryoprotectant Performance Xi Cheng, Mengyuan Li, Shen Yan, Shengyu Zhang, Xiao Dong Chen and Winston Duo Wu Abstract Objectives: Aqueous liposomal suspensions suffer from inherent physical and chemical instability, motivating the development of solid powder formulations. Spray-freeze-drying is a promising… Continue reading Stage-Specific Stability of Spray-Freeze-Dried Ovalbumin-Loaded Liposomes: Dissecting the Impact of Atomization, Freezing, and Drying on Cryoprotectant Performance

Spray Freeze Drying for Solid Formulations of RNA Lipid Nanoparticles K. Arte, Rachana Sapkota, Chanakya D. Patil, Yi-Jing Huang, E. Munson, Sajal M. Patel, Nicole M. Payton, Rushit N. Lodaya, Q. Zhou, L. Qu Abstract Spray-freeze drying (SFD) is a promising drying technique for stabilizing RNA lipid nanoparticles (RNA-LNPs) by converting them into solid-state formulations.… Continue reading Spray Freeze Drying for Solid Formulations of RNA Lipid Nanoparticles

Three-fluid spray-drying vs. spray-freeze-drying of crosslinked alginate microspheres: Elucidating multiscale structure-property relationships for rational design. Zi-Wei Nie, Chong-Zhi Qiu, Meng-Yuan Li, Shen Yan, Sheng-Yu Zhang, Xiao-Dong Chen, W. Wu Abstract Crosslinked alginate microspheres (CLAMs) are promising drug carriers, but conventional two-fluid atomization is limited by premix clogging and formulation complexity. To address these limitations, this… Continue reading Three-fluid spray-drying vs. spray-freeze-drying of crosslinked alginate microspheres: Elucidating multiscale structure-property relationships for rational design.

Single-Step Solvent Evaporation Via Spray-Drying for the Production of Ph-Sensitive Polymeric Nanospheres for Dermatological Applications A. Cardoso, B. Machado, S. S. Guterres, H. R. Marcelino Abstract Polymeric nanospheres are promising drug delivery systems capable of controlling the release of active molecules. However, their inherent colloidal instability necessitates the use of drying techniques to enhance physicochemical… Continue reading Single-Step Solvent Evaporation Via Spray-Drying for the Production of Ph-Sensitive Polymeric Nanospheres for Dermatological Applications

Development and Evaluation of a Novel Inhalable Liposomal Powder Co-Encapsulating ASSNAC and Pirfenidone via Spray Freeze-Drying for Targeted Pulmonary Fibrosis Therapy Qin-Xiu Zhang, Shou-Wei Sun, Miao-Miao Lu, Run-Xin Qin, Jun-Xuan Ren, Lian-Jie Yao, Dian-Long Jia, Jin-Kyu Chang, Xiao-Hong Chu, Rui Wang, Fang Liu, Jun Li Abstract Background: Pulmonary fibrosis (PF) is a progressive lung disease… Continue reading Development and Evaluation of a Novel Inhalable Liposomal Powder Co-Encapsulating ASSNAC and Pirfenidone via Spray Freeze-Drying for Targeted Pulmonary Fibrosis Therapy

Development of Erlotinib Nanoliposome-Loaded Dry Powder Inhaler for Enhanced Pulmonary Delivery Mayur R. Nikam, D. Sonawane, A. Pawar Abstract Objectives: To develop erlotinib nanoliposome-loaded dry powder inhaler formulations for targeted pulmonary delivery in non-small cell lung cancer, addressing the limitations of poor aqueous solubility, systemic toxicity, and suboptimal tumor localization associated with conventional erlotinib therapy.… Continue reading Development of Erlotinib Nanoliposome-Loaded Dry Powder Inhaler for Enhanced Pulmonary Delivery

Improving the Quality of Lyophilized Animal Vaccines: A Review of Optimization Strategies for Freeze-Drying Processes Fang-Jing Huang, Jia-Jie Jiao, Ze-Xi Wang, Hong-Ying Jie, Jia-Hao He, Xiao-Xin Zuo, Yan-Hong Zhao, Yu Lu, Jian-Hong Gu, Fang Lyu Abstract Simple Summary Lyophilization is a well-established technique for the long-term preservation of live vaccines, offering advantages such as superior… Continue reading Improving the Quality of Lyophilized Animal Vaccines: A Review of Optimization Strategies for Freeze-Drying Processes