Category: Scientific papers

Formation of nanofibrous alumina by polyvinyl alcohol assisted sprayfreeze-drying technique Abdur Razzaque, Satoshi Irie, Koji Nakane Abstract In the experiment, three-dimensional net-structured alumina nanofibers were successfully prepared by spray-freeze-dryingprocess for the first time with an average diameter below 100 nm. Alumina nanofibers were obtained from polyvinyl alcohol(PVA) and boehmite precursor nanofibers after calcination at 500… Continue reading Formation of nanofibrous alumina by polyvinyl alcohol assisted sprayfreeze-drying technique

Lyophilised and Thermostable mRNA-Lipid Nanoparticle Vaccines: Excipient Selection, Process Design and Cold–Chain-Independent Distribution for Low- and Middle-Income Countries Anish Verma, Sarbjot Singh, Anita Devi Abstract The messenger RNA lipid nanoparticle (mRNA-LNP) platform reached the clinic at extraordinary speed, yet it carried an inconvenient inheritance: a liquid drug product that survives only at deep sub-zero temperatures.… Continue reading Lyophilised and Thermostable mRNA-Lipid Nanoparticle Vaccines: Excipient Selection, Process Design and Cold-Chain-Independent Distribution for Low- and Middle-Income Countries

From Pharmacological Uncertainty to Inhalation Development: An Evidence-Gated Roadmap for Codonopsis-Derived Triterpenoid Saponins Xiaohua Zhang, Chunxia Yang, Ping Wang, Ping Yang, Shanru Liu, Shubin Liu & Xiaoling Yang Abstract Codonopsis-derived triterpenoid saponins merit investigation because preclinical studies identify immunomodulatory activity and a biologically active parent-metabolite relationship. Pulmonary delivery could increase exposure at a lung target… Continue reading From Pharmacological Uncertainty to Inhalation Development: An Evidence-Gated Roadmap for Codonopsis-Derived Triterpenoid Saponins

Selecting an appropriate binder to prepare alumina granules via spray freeze granulation drying Naoki Kondo, Akihiro Shimamura, Mikinori Hotta, Junichi Tatami, Shinya Kawaguchi Abstract Spray freeze granulation drying (SFGD) is a granulation technique, involving the freezing of sprayed droplets, followed by freeze drying. This technique affords soft granules, which is advantageous for producing sintered bodies… Continue reading Selecting an appropriate binder to prepare alumina granules via spray freeze granulation drying

Application of Natural Polymers to Enhance Probiotic Stability Following the Spray Freeze Drying Method. M. Akrami, Mohammad Mahdi Omranpoor, Milad Imeni, Azadeh Emami, Vahid Ramezani Abstract Probiotics, defined as live microorganisms that confer health benefits on the host, are sensitive to environmental stresses. However, the stability of Lactobacillus casei during spray freeze drying (SFD) under… Continue reading Application of Natural Polymers to Enhance Probiotic Stability Following the Spray Freeze Drying Method.

Tailored Sugar-Mediated Porous Particle Structures for Improved Dispersion of Drug Nanoparticles in Spray-Freeze-Drying. Kumi Semba, Kazunori Kadota, Tero Kämäräinen, Yuzuki Nakayama, Yuta Hatanaka, Hiromasa Uchiyama, H. Arima-Osonoi, Kazumasa Sugiyama, Y. Tozuka Abstract We fabricated porous particles incorporating sugars (mannitol, sucrose, or dextran) and fenofibrate nanoparticles (FNPs) by using spray-freeze-drying (SFD). The type of sugar significantly… Continue reading Tailored Sugar-Mediated Porous Particle Structures for Improved Dispersion of Drug Nanoparticles in Spray-Freeze-Drying.

Water based processing of LiFePO4/C cathode material for Li-ion batteries utilizing freeze granulation Jessica Orlenius, O. Lyckfeldt, Keivan Amiri Kasvayee, P. Johander Abstract A water based solid state synthesis of LiFePO 4 has been conducted by utilizing freeze granulation. Various processing conditions were tested and achieved powder properties were characterized by density, XRD, specific surface… Continue reading Water based processing of LiFePO4/C cathode material for Li-ion batteries utilizing freeze granulation

Influence of Porosity on Performance of Freeze-granulated Fe2O3/Al2O3 Oxygen Carriers Used for Chemical Looping Combustion Yi Zhang, A. Rubel, Sameh Mehrez, J. Neathery, Kunlei Liu Abstract Chemical looping combustion (CLC) is a promising solution for the next coal-fired power generation technology with inherent CO2 separation capability. One of the critical aspects for the development of… Continue reading Influence of Porosity on Performance of Freeze-granulated Fe2O3/Al2O3 Oxygen Carriers Used for Chemical Looping Combustion

Assembled Carbon Nanostructure Prepared by Spray Freeze Drying for Si-Based Anodes Wanxiong Zhu, Liewen Guo, Kairan Li, Mengxue Shen, Chang Lu, Zipeng Jiang, Huaihe Song, Ang Li Abstract Silicon-based materials provide a new pathway to break through the energy storage limits of battery systems but their industrialization process is still constrained by inherent diffusion hysteresis… Continue reading Assembled Carbon Nanostructure Prepared by Spray Freeze Drying for Si-Based Anodes

Li2TiO3 pebble fabrication by freeze granulation & freeze drying method A. Shrivastava, T. Kumar, Riddhi Shukla, P. Chaudhuri Abstract Lithium titanate (Li2TiO3) ceramic is one of the candidate tritium breeding material for fusion reactor. Li2TiO3 in the form of spherical pebbles are kept inside the canisters of the fusion blanket. Prior to pebble fabrication, Li2TiO3… Continue reading Li2TiO3 pebble fabrication by freeze granulation & freeze drying method