Spray Freeze-Drying as an Alternative to the Ionic Gelation Method to Produce Chitosan and Alginate Nano-Particles Targeted to the Colon Gamboa A, Araujo V, Caro N, Gotteland M, Abugoch L, Tapia C Abstract Chitosan and alginate nano-composite (NP) carriers intended for colonic delivery containing prednisolone and inulin were obtained by two processes. Spray freeze-drying using… Continue reading Spray Freeze-Drying as an Alternative to the Ionic Gelation Method to Produce Chitosan and Alginate Nano-Particles Targeted to the Colon
Nanoembedded Microparticles for Stabilization and Delivery of Drug-Loaded Nanoparticles Bohr A, Water J, Beck-Broichsitter M, Yang M Abstract Nanoparticle-based pharmaceutical products are currently finding their way onto the market as a popular strategy to improve the therapeutic efficacy of numerous drugs, hereunder medications for a targeted treatment of severe diseases (e.g., cancer). Drug-loaded polymer and… Continue reading Nanoembedded Microparticles for Stabilization and Delivery of Drug-Loaded Nanoparticles
ECerS XIII – Granulation of Nanoparticles – During first day at the conference we have had interesting discussions on how Freeze Granulation can help to make homogeneous granules of, for example, Carbon Nanotubes (CNT).
Freeze Granulation of thermally sensitive nanoparticles By using Freeze Granulation, spray freeze drying (SFD), you can produce dry-powder aggregates of thermally sensitive nanoparticles. Dry powder inhaler (DPI) delivery of therapeutic nanoparticles requires the nanoparticles to be transformed into inhalable micro-scale aggregate structures (i.e. nano-aggregates). With Freeze Granulation you will be able to optimize the aerosolization… Continue reading Thermally sensitive nanoparticles
Nano ice in granules by Freeze Granulation Nano ice formation in granules by Freeze Granulation process is a key factor for the unique homogeneity of particles and binders achieved in the resulting granules. This is especially important for nanopowders, fine particles and binders where migration of these could occur during conventional drying, like spray drying. Please contact us and… Continue reading Nano ice formation in granules
Typical applications for Freeze Granulation are homogeneous granulation and drying of engineering (advanced, fine, high-performance) ceramic powders; oxides (alumina (Al2O3), zirconia (ZrO2), silica (SiO2)), nitrides (silicon nitride (Si3N4)) and carbides (SiC) and also granulation of powders of metal oxides, plasma spraying, nanomaterials (nanopowders), diamonds (PCD/CBN inserts), LED Lighting, pyrotechnicals (igniters, delay elements) and drying of pharmaceuticals and drugs, and for drying… Continue reading Applications for Freeze Granulation
Processing of nanoparticles using Freeze Granulation, Spray Freeze Drying, you will get optimal properties of your nanoparticles when mixing them with other powders or materials. The homogeneity of the powder mixture will be kept throughout the process steps, in spraying, freezing and drying, resulting in a dry granulate with homogeneously distributed nanoparticles.
By using Freeze Granulation, spray freeze drying (SFD), you can produce dry-powder aggregates of thermally sensitive nanoparticles. Dry powder inhaler (DPI) delivery of therapeutic nanoparticles requires the nanoparticles to be transformed into inhalable micro-scale aggregate structures (i.e. nano-aggregates). With Freeze Granulation you will be able to optimize the aerosolization efficiency of the nano-aggregates, while keeping… Continue reading Thermally sensitive nanoparticles
By applying Freeze Granulation on your agglomerated nanoparticles or submicron powders you will be able to deagglomerate them forming a homogeneous well-dispersed particles or mixture of particles. Please contact us and we will further discuss the opportunities with Freeze Granulation on your powder system and read more on technology and we propose a Granulation Test of your powder… Continue reading Deagglomeration of nanoparticles and other submicron powders
We have long experience in handling and processing of nanoparticles/nanopowders, for example, mix and granulate different powders and binders for to achieve improved homogeneity and increased performance of the final product. Freeze granulation gives the possibility to granulate nanoparticles/nanopowders achieving granules with high degree of homogeneity which are easily re-dispersed (if applicable) in a liquid or dis-integrated at a pressing operation.… Continue reading Handling and Processing of Nanopowders