Dry powder formulation of plasmid DNA and siRNA for inhalation Chow MY, Lam JK Abstract Nucleic acid therapeutics has huge potential for the treatment of a wide range of diseases including respiratory diseases. Plasmid DNA (pDNA) and small interfering RNA (siRNA) are the two most widely investigated nucleic acids for therapeutic development. However, efficient and… Continue reading Dry powder formulation of plasmid DNA and siRNA for inhalation
Dry powder inhaler formulation of high-payload antibiotic nanoparticle complex intended for bronchiectasis therapy: Spray drying versus spray freeze drying preparation Yu H, Teo J, Chew JW, Hadinoto K Abstract Inhaled nano-antibiotics have recently emerged as the promising bronchiectasis treatment attributed to the higher and more localized antibiotic exposure generated compared to native antibiotics. Antibiotic nanoparticle… Continue reading Dry powder inhaler formulation of high-payload antibiotic nanoparticle complex intended for bronchiectasis therapy: Spray drying versus spray freeze drying preparation
Spray Freeze-Drying as an Alternative to the Ionic Gelation Method to Produce Chitosan and Alginate Nano-Particles Targeted to the Colon Gamboa A, Araujo V, Caro N, Gotteland M, Abugoch L, Tapia C Abstract Chitosan and alginate nano-composite (NP) carriers intended for colonic delivery containing prednisolone and inulin were obtained by two processes. Spray freeze-drying using… Continue reading Spray Freeze-Drying as an Alternative to the Ionic Gelation Method to Produce Chitosan and Alginate Nano-Particles Targeted to the Colon
Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders Maria Malamatari, Satyanarayana Somavarapu, Kevin M.G. Taylor & Graham Buckton Abstract Introduction: Nanosuspensions combine the advantages of nanotherapeutics (e.g. increased dissolution rate and saturation solubility) with ease of commercialisation. Transformation of nanosuspensions to solid oral and inhalable dosage forms minimises… Continue reading Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders
Inhalable nanocomposite microparticles: Preparation, characterization and factors affecting formulation Elsayed I, AbouGhaly MH Abstract INTRODUCTION: Nanocomposite microparticles are intelligent carriers utilised for pulmonary drug delivery. These carriers are composed of drug-encapsulated nanoparticles dispersed in microstructures of polysaccharides. Upon administration, the inhaled microparticles can penetrate and be deposited deeply in the lung due to their adjusted… Continue reading Inhalable nanocomposite microparticles: Preparation, characterization and factors affecting formulation
Nanoembedded Microparticles for Stabilization and Delivery of Drug-Loaded Nanoparticles Bohr A, Water J, Beck-Broichsitter M, Yang M Abstract Nanoparticle-based pharmaceutical products are currently finding their way onto the market as a popular strategy to improve the therapeutic efficacy of numerous drugs, hereunder medications for a targeted treatment of severe diseases (e.g., cancer). Drug-loaded polymer and… Continue reading Nanoembedded Microparticles for Stabilization and Delivery of Drug-Loaded Nanoparticles
Pharmaceutical spray freeze drying Stefan Wanning, Richard Süverkrüp, Alf Lamprecht Abstract Pharmaceutical spray-freeze drying (SFD) includes a heterogeneous set of technologies with primary applications in apparent solubility enhancement, pulmonary drug delivery, intradermal ballistic administration and delivery of vaccines to the nasal mucosa. The methods comprise of three steps: droplet generation, freezing and sublimation drying, which… Continue reading Pharmaceutical spray freeze drying
Processing of nanoparticles using Freeze Granulation, Spray Freeze Drying, you will get optimal properties of your nanoparticles when mixing them with other powders or materials. The homogeneity of the powder mixture will be kept throughout the process steps, in spraying, freezing and drying, resulting in a dry granulate with homogeneously distributed nanoparticles.
By using Freeze Granulation – Spray Freeze Drying – you will be able to avoid donut-shaped granules. — Please contact us and we will further discuss the opportunities with Freeze Granulation on your powder system and read more on technology and we propose a Granulation Test of your powder system.
If you would like to test-granulate your powders or chemicals using Freeze Granulation, please contact us for details. You send your material and binders to us, we make the test-granulation using freeze granulation and then send the granulated material (granulaes) back to you for your evaluation and testing. Freeze granulation is considered to be a natural tool in most… Continue reading Interested in test-granulation of your material?