Category: Scientific papers

Rivaroxaban lyospheres prepared by a dimethyl sulfoxide-based spray-freeze-drying process Jan Kožák, Claire Chrétien, Yann Pellequer, Alf Lamprecht Abstract Spray-freeze-drying (SFD) processes are usually using aqueous solvent systems, which however, exclude the use of SFD for poorly water-soluble drugs/excipients. Here, we evaluated dimethyl sulfoxide for its suitability in formulating SFD particles (lyospheres®). Rivaroxaban was spray-freeze-dried from… Continue reading Rivaroxaban lyospheres prepared by a dimethyl sulfoxide-based spray-freeze-drying process

Synthesis of hierarchical ZSM-5 microspheres with superior performance for catalytic methanol-to-olefin conversion Yali Zhang, Kai Zhang, Chao Shang, Xiaoning Wang, Lei Wu, Guoqing Huang, Hao Wang, Qiming Sun, Xiao Dong Chen, Zhangxiong Wu Abstract Methanol-to-olefin (MTO) conversion on zeolites has encountered severe coke deposition and rapid deactivation. Creating different levels of porosity is essential to… Continue reading Synthesis of hierarchical ZSM-5 microspheres with superior performance for catalytic methanol-to-olefin conversion

Nanoencapsulation of antioxidant peptides from Lupinus mutabilis in chitosan nanoparticles obtained by ionic gelling and spray freeze drying intended for colonic delivery Arturo Intiquilla, Karim Jiménez-Aliaga, Amparo Iris Zavaleta, Alexander Gamboa, Nelson Caro, Mario Diaz, Martin Gotteland, Lilian Abugoch, Cristian Tapia Abstract Oxidative stress has long been associated with the pathogenesis of inflammatory bowel disease… Continue reading Nanoencapsulation of antioxidant peptides from Lupinus mutabilis in chitosan nanoparticles obtained by ionic gelling and spray freeze drying intended for colonic delivery

Whey protein hydrolysates as prebiotic and protective agent regulate growth and survival of Lactobacillus rhamnosus CICC22152 during spray/freeze-drying, storage and gastrointestinal digestion Hexiang Xie, Yang Liao, Meng Wai Woo, Hua Xiong, Qiang Zhao Abstract BACKGROUNDProbiotic products are receiving increasing attention because of their tremendous beneficial health effects. However, it is still a great challenge to… Continue reading Whey protein hydrolysates as prebiotic and protective agent regulate growth and survival of Lactobacillus rhamnosus CICC22152 during spray/freeze-drying, storage and gastrointestinal digestion

Grain size analysis and characterization by Raman spectroscopy of a homogeneous sintered MOX fuel Marion Le Guellec, Florent Lebreton, Laure Ramond, Philippe Martin, Abibatou Ndiaye, Thierry Gervais, Guillaume Bernard-Granger Abstract The grain size distribution of an U0.89Pu0.11O2 MOX fuel, sintered from a freeze-granulated powder to 97% of the theoretical density at 1700 °C during 4 h, for… Continue reading Grain size analysis and characterization by Raman spectroscopy of a homogeneous sintered MOX fuel

Spray-freeze-dried lyospheres: Solid content and the impact on flowability and mechanical stability Annika Rautenberg, Alf Lamprecht Abstract Handling low-density pharmaceutical products, such as lyophilisates, presents a challenge. Spray-freeze-dried (SFD) particles, overcoming many of these challenges, were analysed regarding flowability, mechanical stability, product properties (morphology, particle size) and physicochemical properties of the spraying solution (density, viscosity,… Continue reading Spray-freeze-dried lyospheres: Solid content and the impact on flowability and mechanical stability

Characterization by electron probe microanalysis, Raman spectroscopy and transmission electron microscopy of a MOX fuel sintered from a freeze-granulated powder Julie Simeon, Florent Lebreton, Laure Ramond, Philippe Martin, Doris Drouan, Catherine Sabathier, Guillaume Bernard-Granger Abstract The microstructure of a 98.7 % dense U0.856Pu0.144O1.993 sintered sample (average grain size around 1.5 µm) has been characterized by electron… Continue reading Characterization by electron probe microanalysis, Raman spectroscopy and transmission electron microscopy of a MOX fuel sintered from a freeze-granulated powder

Selectivity of Ru-rich Ru-Ti-O oxide surfaces in parallel oxygen and chlorine evolution reactions Kateřina Minhová Macounová, Rebecca Katharina Pittkowski, Roman Nebel, Andrea Zitolo, Petr Krtil Abstract The electrocatalytic behaviour of single-phase Ru1-xTixO2 materials was studied to outline general trends controlling the selectivity of oxide-based anodes in parallel oxygen evolution and chlorine evolution reactions. Materials with… Continue reading Selectivity of Ru-rich Ru-Ti-O oxide surfaces in parallel oxygen and chlorine evolution reactions

Effects of drying methods on physical properties and morphology of trehalose/mannitol mixtures Daniel Tristan Osanlóo, Jonas Fransson, Björn Bergenståhl, Anna Millqvist-Fureby Abstract Solid-state properties of dried protein formulations are important for stability and functionality of the product. This study investigates how different drying technologies (freeze-drying with and without annealing, spray drying and spray-freeze drying) affect… Continue reading High fine particle fractionEffects of drying methods on physical properties and morphology of trehalose/mannitol mixtures

Micro-fluidic Spray Freeze Dried Ciprofloxacin Hydrochloride-Embedded Dry Powder for Inhalation Yingjie Chen, Shen Yan, Shengyu Zhang, Quanyi Yin, Xiao Dong Chen, Winston Duo Wu Abstract Active pharmaceutical ingredient (API)-embedded dry powder for inhalation (AeDPI) is highly desirable for pulmonary delivery of high-dose drug. Herein, a series of spray freeze-dried (SFD) ciprofloxacin hydrochloride (CH)-embedded dry powders… Continue reading Micro-fluidic Spray Freeze Dried Ciprofloxacin Hydrochloride-Embedded Dry Powder for Inhalation