Category: Scientific papers

Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders

Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders Maria Malamatari, Satyanarayana Somavarapu, Kevin M.G. Taylor & Graham Buckton Abstract Introduction: Nanosuspensions combine the advantages of nanotherapeutics (e.g. increased dissolution rate and saturation solubility) with ease of commercialisation. Transformation of nanosuspensions to solid oral and inhalable dosage forms minimises… Continue reading Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders

Inhalable nanocomposite microparticles: Preparation, characterization and factors affecting formulation

Inhalable nanocomposite microparticles: Preparation, characterization and factors affecting formulation Elsayed I, AbouGhaly MH Abstract INTRODUCTION: Nanocomposite microparticles are intelligent carriers utilised for pulmonary drug delivery. These carriers are composed of drug-encapsulated nanoparticles dispersed in microstructures of polysaccharides. Upon administration, the inhaled microparticles can penetrate and be deposited deeply in the lung due to their adjusted… Continue reading Inhalable nanocomposite microparticles: Preparation, characterization and factors affecting formulation

Nanoembedded Microparticles for Stabilization and Delivery of Drug-Loaded Nanoparticles

Nanoembedded Microparticles for Stabilization and Delivery of Drug-Loaded Nanoparticles Bohr A, Water J, Beck-Broichsitter M, Yang M Abstract Nanoparticle-based pharmaceutical products are currently finding their way onto the market as a popular strategy to improve the therapeutic efficacy of numerous drugs, hereunder medications for a targeted treatment of severe diseases (e.g., cancer). Drug-loaded polymer and… Continue reading Nanoembedded Microparticles for Stabilization and Delivery of Drug-Loaded Nanoparticles

Spark plasma sintering of zirconia/nano-nickel composites

Spark plasma sintering of zirconia/nano-nickel composites Carlos F. Gutierrez-Gonzalez, Nestor W. Solis Pinargote, Said Agouram,Pavel Y. Peretyagin, Sonia Lopez-Esteban and Ramon Torrecillas Abstract This work describes a whole processing route for obtaining dense and nanostructured zirconia-nickel composites with low contents of metallic phase (1–3.5 vol%). For the processing route, a combinationof spray-freezing and lyophilization has… Continue reading Spark plasma sintering of zirconia/nano-nickel composites

Inhalable Spray-Freeze-Dried Powder with L-Leucine that Delivers Particles Independent of Inspiratory Flow Pattern and Inhalation Device

Inhalable Spray-Freeze-Dried Powder with L-Leucine that Delivers Particles Independent of Inspiratory Flow Pattern and Inhalation Device Otake H, Okuda T, Hira D, Kojima H, Shimada Y, Okamoto H Abstract PURPOSE: The purpose of this study was to develop inhalable particles that can reach deep into the lungs efficiently independent of inhalation patterns of patients and… Continue reading Inhalable Spray-Freeze-Dried Powder with L-Leucine that Delivers Particles Independent of Inspiratory Flow Pattern and Inhalation Device

Fabrication and optical studies of transparent Tm, Ho:YAG ceramics

Fabrication and optical studies of transparent Tm, Ho:YAG ceramics Agata Sidorowicz, Magdalena Nakielska, Anna Wajler, Helena Węglarz, Katarzyna Jach, Andrzej Olszyna Abstract The aim of this work has been to obtain transparent Tm, Ho:YAG ceramics (thulium doping range: 2–6 at.%, holmium doping range: 0.1–1.0 at.%) by reaction sintering using commercial powders. It has been proved that the… Continue reading Fabrication and optical studies of transparent Tm, Ho:YAG ceramics

Spray Freeze Granulation of Submicron Alumina and its Sintering Behavior via Spark Plasma Sintering

Spray Freeze Granulation of Submicron Alumina and its Sintering Behavior via Spark Plasma Sintering Wei Liu, Zhipeng Xie Abstract: Spray freeze granulation is an improved method based on spray granulation, solving many limitations of spray granulation. In this work, spray freeze granulation of submicron alumina is performed to explore the possibility of industrial-scale production of… Continue reading Spray Freeze Granulation of Submicron Alumina and its Sintering Behavior via Spark Plasma Sintering

Injectability of calcium phosphate pastes: Effects of particle size and state of aggregation of β-tricalcium phosphate powders

Injectability of calcium phosphate pastes: Effects of particle size and state of aggregation of β-tricalcium phosphate powders Torres PM, Gouveia S, Olhero S, Kaushal A, Ferreira JM Abstract The present study discloses a systematic study about the influence of some relevant experimental variables on injectability of calcium phosphate cements. Non-reactive and reactive pastes were prepared,… Continue reading Injectability of calcium phosphate pastes: Effects of particle size and state of aggregation of β-tricalcium phosphate powders