Category: Scientific papers

Spray-freeze-drying in the manufacture of pharmaceuticals Abstract Over the last decade, the development of new drug delivery methods and devices for dry powder inhalation1, needle-free intradermal powder injection2 or sustained parenteral drug delivery3 has led to an increasing demand for powder formulations incorporating an active pharmaceutical ingredient (API)4,5. In contrast to the production and handling… Continue reading Spray-freeze-drying in the manufacture of pharmaceuticals

Protein Spray-Freeze Drying. Effect of Atomization Conditions on Particle Size and Stability Henry R CostantinoLaleh FirouzabadianKen HogelandChichih WuChris BeganskiKaren G CarrasquilloMelissa CórdovaKai GriebenowStephen E ZaleMark A Tracy Abstract Purpose. To investigate the effect of atomization conditions on particle size and stability of spray-freeze dried protein. Methods. Atomization variables were explored for excipient-free (no zinc added)… Continue reading Protein Spray-Freeze Drying. Effect of Atomization Conditions on Particle Size and Stability

Spray-freeze-drying of nanosuspensions: the manufacture of insulin particles for needle-free ballistic powder delivery Heiko Schiffter, Jamie Condliffe, Sebastian Vonhoff Abstract The feasibility of preparing microparticles with high insulin loading suitable for needle-free ballistic drug delivery by spray-freeze-drying (SFD) was examined in this study. The aim was to manufacture dense, robust particles with a diameter of… Continue reading Spray-freeze-drying of nanosuspensions: the manufacture of insulin particles for needle-free ballistic powder delivery

A spray-freezing approach to reduced graphene oxide/MoS2 hybrids for superior energy storage Tao Cheng, Jin Xu, Ziqi Tan, Jianglin Ye, Zhuchen Tao, Zhenzhen Du, Ying Wu, Shuilin Wu, Hengxing Ji, Yan Yu. Yanwu Zhu Abstract A three-dimensional (3D) architectural hybrid, composed of reduced graphene oxide (RGO) and ultrathin MoS2 layers, is fabricated by a facile… Continue reading A spray-freezing approach to reduced graphene oxide/MoS2 hybrids for superior energy storage

Development of Inhalable Dry Powder Formulations Loaded with Nanoparticles Maintaining Their Original Physical Properties and Functions Okuda T Abstract Functional nanoparticles, such as liposomes and polymeric micelles, are attractive drug delivery systems for solubilization, stabilization, sustained release, prolonged tissue retention, and tissue targeting of various encapsulated drugs. For their clinical application in therapy for pulmonary… Continue reading Development of Inhalable Dry Powder Formulations Loaded with Nanoparticles Maintaining Their Original Physical Properties and Functions

Shrinkage of spray-freeze-dried microparticles of pure protein for ballistic injection by manipulation of freeze-drying cycle Straller G, Lee G Abstract Spray-freeze-drying was used to produce shrivelled, partially-collapsed microparticles of pure proteins that may be suitable for use in a ballistic injector. Various modifications of the freeze drying cycle were examined for their effects on collapse… Continue reading Shrinkage of spray-freeze-dried microparticles of pure protein for ballistic injection by manipulation of freeze-drying cycle

Mechanical particle coating using polymethacrylate nanoparticle agglomerates for the preparation of controlled release fine particles: The relationship between coating performance and the characteristics of various polymethacrylates. Kondo K, Kato S, Niwa T Abstract We aimed to understand the factors controlling mechanical particle coating using polymethacrylate. The relationship between coating performance and the characteristics of polymethacrylate… Continue reading Mechanical particle coating using polymethacrylate nanoparticle agglomerates for the preparation of controlled release fine particles: The relationship between coating performance and the characteristics of various polymethacrylates.

Preparation and Characterization of Pentoxyverine Citrate Micro-Nano Particle Aggregations Bo Chen, Hui Tang, Yong Peng Huang, Jian Lan Jiao, Chuan Pin Zou Abstract Micro-nano drug particle aggregations were prepared by shearing emulsification, high pressure homogenization and spray freeze drying, particle formational process and optimization of preparation conditions were analyzed, and micro-morphologies, particle size distributions, aerodynamic… Continue reading Preparation and Characterization of Pentoxyverine Citrate Micro-Nano Particle Aggregations

Structured emulsion-templated porous copolymer based on photopolymerization for carbon capture Dariush Nikjoo, Farid Akhtar Abstract Porous hydrogel copolymers of acrylamide (AAM) and acrylic acid (AAC) were structured in the form of monoliths and granules. AAM-co-AAC porous copolymer monoliths were synthesized using high internal phase emulsion (HIPE) as template and photopolymerization. For granulation, photopolymerization was used… Continue reading Structured emulsion-templated porous copolymer based on photopolymerization for carbon capture

Phase change and droplet dynamics for a free falling water droplet K.R. Sultana, K. Pope, L.S. Lam, Y.S. Muzychka Abstract This paper numerically examines phase change of free falling droplets in a sub-zero environment. The model is based on the solution of the Navier-Stokes equations coupled with the Volume of Fluid (VOF) methodology for tracking… Continue reading Phase change and droplet dynamics for a free falling water droplet