Category: Scientific papers

Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition Liao Q, Yip L, Chow MYT, Chow SF, Chan HK, Kwok PCL, Lam JKW Abstract Systemic administration of antifungal agents for the treatment of pulmonary aspergillosis is limited by the poor lung deposition and severe adverse… Continue reading Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition

Fabrication of homogenous pellets by freeze granulation of optimized TiO2-Y2O3 suspensions F. La Lumia, L. Ramond, C. Pagnoux, G. Bernard-Granger Abstract MOX fuels are used in nuclear reactors. To ensure the manufacture of MOX, wet processes are investigated. Freeze granulation of water-based powder suspension seems a promising way to yield homogenous and easy-to-press UO2-PuO2 granules.… Continue reading Fabrication of homogenous pellets by freeze granulation of optimized TiO2-Y2O3 suspensions

Supporting data and methods for the multi-scale modelling of freeze-drying of microparticles in packed-beds Luigi C. Capozzi, Antonello A. Barresi, Roberto Pisano Abstract A multi-scale approach can be used to simulate the drying behavior of microparticles in packed-bed. Data outcomes from discrete element method (DEM) and computational fluid dynamics (CFD) simulations can be used to… Continue reading Supporting data and methods for the multi-scale modelling of freeze-drying of microparticles in packed-beds

Cryogenic Fabrication of Dry Powders to Enhance the Solubility of a Promising Anticancer Drug, SHetA2, for Oral Administration Ibrahim M, Hatipoglu MK, Garcia-Contreras L Abstract SHetA2 is a novel anticancer drug with poor aqueous solubility. In formal toxicological studies, Kolliphor HS 15 was used as a solubilizing agent to increase the oral bioavailability of SHetA2.… Continue reading Cryogenic Fabrication of Dry Powders to Enhance the Solubility of a Promising Anticancer Drug, SHetA2, for Oral Administration.

Influence of Nanoparticle Pretreatment on the Thermal, Rheological and Mechanical Properties of PLA-PBSA Nanocomposites Incorporating Cellulose Nanocrystals or Montmorillonite Wissam Abdallah, Amin Mirzadeh, Victor Tan, Musa R. Kamal Abstract Nanoparticles based on cellulose nanocrystals (CNC) and montmorillonite clay (MMT) were prepared using spray freeze-drying. The nanoparticles were then used as reinforcement to prepare nanocomposites with… Continue reading Influence of Nanoparticle Pretreatment on the Thermal, Rheological and Mechanical Properties of PLA-PBSA Nanocomposites Incorporating Cellulose Nanocrystals or Montmorillonite

Spray Freeze-Drying Technology: Enabling Flexibility of Supply Chain and Drug-Product Presentation for Biologics Deirdre Lowe, Mehak Mehta, Geetha Govindan, Kapil Gupta Abstract Biopharmaceutical drug substances (DSs) and drug products (DPs) commonly are stored frozen or refrigerated to maintain stability through long-term storage, handling, and transportation (1). Temperature excursions during storage and transport can affect product… Continue reading Spray Freeze-Drying Technology: Enabling Flexibility of Supply Chain and Drug-Product Presentation for Biologics

Pharmaceutical Freeze Drying Technology 2018 Overview Although an old process, pharmaceutical freeze drying is ever evolving with new trends and approaches being used for pharmaceutical formulation. In it’s 6th year, the conference will cover the most recent advances in Freeze drying technology and discuss the latest ideas in the industry. It is the perfect platform… Continue reading Pharmaceutical Freeze Drying Technology 2018

Spray-freeze-drying: A novel process for the drying of foods and bioproducts S. Padma Ishwarya, C. Anandharamakrishnan, Andrew G.F. Stapley Abstract Spray-freeze-drying (SFD) is an unconventional freeze drying technique that produces uniquely powdered products whilst still including the benefits of conventionally freeze dried products. SFD has potential applications in high value products due to its edge… Continue reading Spray-freeze-drying: A novel process for the drying of foods and bioproducts

Comparison of Freeze and Spray Drying to Obtain Primaquine-Loaded Solid Lipid Nanoparticles Owuor James, Florence Oloo, Japheth Kibet Ngetich, Mwaiwa Kivunzya Abstract This article describes how the spray drying and freeze drying of various nanosized Solid Lipid Nanoparticle (SLN) and the physicochemical attributes of the acquired particles were examined. Primaquine loaded Solid Lipid Nanoparticles dried… Continue reading Comparison of Freeze and Spray Drying to Obtain Primaquine-Loaded Solid Lipid Nanoparticles

Thermal inactivation kinetics of microencapsulated microbial transglutaminase by ultrasonic spray-freeze drying Hilal Isleroglu, Izzet Turker Abstract Partially purified microbial transglutaminase (mTG) was microencapsulated by ultrasonic spray-freeze drying (USFD) as a novel method, using a 48 kHz ultrasonic nozzle. The microencapsulated samples, which used a mixture of inulin and gum arabic as coating materials, were compared to… Continue reading Thermal inactivation kinetics of microencapsulated microbial transglutaminase by ultrasonic spray-freeze drying