Category: Scientific papers

Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals Fakhrossadat Emami, Alireza Vatanara, Eun Ji Park, Dong Hee Na Abstract Solid dosage forms of biopharmaceuticals such as therapeutic proteins could provide enhanced bioavailability, improved storage stability, as well as expanded alternatives to parenteral administration. Although numerous drying methods have been used for preparing dried protein… Continue reading Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals

Influence of process variables on physical characteristics of spray freeze dried cellulose nanocrystals Wissam Abdallah, Musa R. Kamal Abstract This study compares the characteristics of cellulose nanocrystal (CNC) agglomerates prepared using spray drying, freeze drying, and spray freeze drying. Moreover, the effect of the concentration of CNC in the initial aqueous dispersion (~ 0.5–10.0 wt%) on… Continue reading Influence of process variables on physical characteristics of spray freeze dried cellulose nanocrystals

Ultrasonic spray-freeze drying of partially purified microbial transglutaminase Hilal Isleroglu, Izzet Turker, Mehmet Tokatli, Banu Koc Abstract Ultrasonic spray-freeze drying (USFD) was evaluated to produce partially purified microbial transglutaminase (mTGase) powder, and the effects of the process conditions (a nozzle frequency of 48–120 kHz and a flow rate of 2–8 ml/min) on enzyme activity and… Continue reading Ultrasonic spray-freeze drying of partially purified microbial transglutaminase

Encapsulation of cationic iridium(III) tetrazole complexes into a silica matrix: synthesis, characterization and optical properties Ilaria Zanoni, Valentina Fiorini, Marcos Rosado, Belén Ballesteros, Maria Androulidaki, Magda Blosi, Simona Ortelli, Stefano Stagni, Michele Dondia and Anna Luisa Costa Abstract Herein we report the easy incorporation of brightly phosphorescent cationic iridium(III) tetrazole complexes into a silica based… Continue reading Encapsulation of cationic iridium(III) tetrazole complexes into a silica matrix: synthesis, characterization and optical properties

Spray freeze-dried monolithic silica aerogel based on water-glass with thermal superinsulating properties Yuelei Pan, Xudong Cheng, Ting zhou, Lunlun Gong, Heping Zhang Abstract In this study, silica aerogels were prepared using water-glass precursor based on two drying strategies, namely conventional freeze drying (C-FD) and spray freeze drying (S-FD). It was known that the pore structure… Continue reading Spray freeze-dried monolithic silica aerogel based on water-glass with thermal superinsulating properties

Porous Microparticles Containing Raloxifene Hydrochloride Tailored by Spray Freeze Drying for Solubility Enhancement Seyyed Pouya Hadipour Moghaddam, Sajjad Farhat, Alireza Vatanara Abstract Purpose: The goal of this study was to improve the solubility and dissolution behavior of Raloxifene Hydrochloride (RH) using Spray Freeze Drying (SFD) technique. Methods: For achieving this goal, series of samples containing… Continue reading Porous Microparticles Containing Raloxifene Hydrochloride Tailored by Spray Freeze Drying for Solubility Enhancement

Spray-Freeze Drying: a Suitable Method for Aerosol Delivery of Antibodies in the Presence of Trehalose and Cyclodextrins Pouya MA, Daneshmand B, Aghababaie S, Faghihi H, Vatanara A Abstract We aimed to prepare spray-freeze-dried powder of IgG considering physicochemical stability and aerodynamic aspects. Spray-freeze drying (SFD) exposes proteins to various stresses which should be compensated by… Continue reading Spray-Freeze Drying: a Suitable Method for Aerosol Delivery of Antibodies in the Presence of Trehalose and Cyclodextrins.

Effect of amino acids on the stability of spray freeze-dried immunoglobulin G in sugar-based matrices Fakhrossadat Emami, Alireza Vatanara, Abdolhosein Rouholamini Najafabadi, Yejin Kim, Eun Ji Park, Soroush Sardari, Dong Hee Na Abstract The purpose of this study was to prepare spray freeze-dried particles of immunoglobulin G (IgG) using various combinations of trehalose and different… Continue reading Effect of amino acids on the stability of spray freeze-dried immunoglobulin G in sugar-based matrices

Effect of the microstructure on the stability of red onion microcapsules E. Flores-Andrade, E. Bonilla, G. Luna-Solano, U. R. Marin, M. T. González-Arnao, M. P. Rascón Abstract The effect of microstructure on the stability of red onion encapsulated by two processes: (a) spray drying and (b) spray freezing into liquid cryogenic, was evaluated in this… Continue reading Effect of the microstructure on the stability of red onion microcapsules

Microstructure of high battery-performance Li2FeSiO4/C composite powder synthesized by combining different carbon sources in spray-freezing/freeze-drying process Yukiko Fujita, Tomoaki Hira, Kenji Shida, Masayuki Tsushida, Jinsun Liao, Motohide Matsuda Abstract Spray-freezing/freeze-drying technique was applied to the synthesis of Li2FeSiO4/C composite powders using solutions containing various carbon sources, water-soluble and colloidal carbon, followed by heat treatment. The… Continue reading Microstructure of high battery-performance Li2FeSiO4/C composite powder synthesized by combining different carbon sources in spray-freezing/freeze-drying process