Binder Jetting Additive Manufacturing of Ceramics: Feedstock Powder Preparation by Spray Freeze Granulation

Binder Jetting Additive Manufacturing of Ceramics: Feedstock Powder Preparation by Spray Freeze Granulation Wenchao Du, Guanxiong Miao, Lianlian Liu, Zhijian Pei Abstract Objective of this study is to prepare the binder jetting feedstock powder by spray freeze drying and study the effects of its parameters on the powder properties. Binder jetting additive manufacturing is a… Continue reading Binder Jetting Additive Manufacturing of Ceramics: Feedstock Powder Preparation by Spray Freeze Granulation

Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections

Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections Shihui Yu, Shaoning Wang, Peizhi Zou, Guihong Chai, Yu-Wei Lin, Tony Velkov, Jian Li, Weisan Pan, Qi Tony Zhou Abstract The aim of this study was to design and characterize dry powder inhaler formulations of ciprofloxacin and colistin… Continue reading Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections

Naked pDNA/hyaluronic acid powder shows excellent long-term storage stability and gene expression in murine lungs

Naked pDNA/hyaluronic acid powder shows excellent long-term storage stability and gene expression in murine lungs Takaaki Ito, Maino Fukuhara, Tomoyuki Okuda, Hirokazu Okamoto Abstract We evaluated the storage stability of powder containing naked plasmid DNA (pDNA) and hyaluronic acid (HA) or mannitol (Man) prepared by the spray-freeze-drying technique, through which we have reported high gene… Continue reading Naked pDNA/hyaluronic acid powder shows excellent long-term storage stability and gene expression in murine lungs

Effects of liquid nitrogen quick freezing on polyphenol oxidase and peroxide activities, cell water states and epidermal microstructure of wolfberry

Effects of liquid nitrogen quick freezing on polyphenol oxidase and peroxide activities, cell water states and epidermal microstructure of wolfberry ZhiweiZhu, Wenhuang Lou, Da-Wen Sun Abstract Fresh wolfberry has a very short shelf-life and drying is the most common method for preserving wolfberry. For better retention of the quality and nutritional values of wolfberry, effects… Continue reading Effects of liquid nitrogen quick freezing on polyphenol oxidase and peroxide activities, cell water states and epidermal microstructure of wolfberry

Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide Abstract Pulmonary delivery of messenger RNA (mRNA) has considerable potential as therapy or vaccine for a range of lung diseases. Inhaled dry powder formulation of mRNA is particularly attractive as it has superior stability and dry powder inhaler is relatively easy to… Continue reading Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

Effect of Particle Formation Process on Characteristics and Aerosol Performance of Respirable Protein Powders.

Effect of Particle Formation Process on Characteristics and Aerosol Performance of Respirable Protein Powders Brunaugh AD, Wu T, Kanapuram SR, Smyth HDC Abstract Pulmonary delivery of biopharmaceuticals may enable targeted local therapeutic effect and noninvasive systemic administration. Dry powder inhaler (DPI) delivery is an established patient-friendly approach for delivering large molecules to the lungs; however,… Continue reading Effect of Particle Formation Process on Characteristics and Aerosol Performance of Respirable Protein Powders.

A spray freeze dried micropellet based formulation proof-of-concept for a yellow fever vaccine candidate

A spray freeze dried micropellet based formulation proof-of-concept for a yellow fever vaccine candidate Clénet D, Hourquet V, Woinet B, Ponceblanc H, Vangelisti M Abstract The stability of live-attenuated viruses is very challenging due to thermal sensitivity; therefore, solid form is usually required (often freeze-dried products). Micropellet technology is a lyophilization technology that has the… Continue reading A spray freeze dried micropellet based formulation proof-of-concept for a yellow fever vaccine candidate

Microwave heating synthesis and luminescence of NaY(WO4)2:(Ho3+, Yb3+) phosphors

Microwave heating synthesis and luminescence of NaY(WO4)2:(Ho3+, Yb3+) phosphors Yang Yang, Hao Feng, Xiuguo Zhang Abstract NaY(WO4)(2):(Ho3+, Yb3+) phosphors were synthesized by microwave heating in an EDTA-mediated process. The samples were characterized by XRD, FT-IR, SEM, and fluorescence spectrophotometer. The XRD and FT-IR results show that the samples have the tetragonal phase. The SEM results… Continue reading Microwave heating synthesis and luminescence of NaY(WO4)2:(Ho3+, Yb3+) phosphors

Preparation and characterization of nano amitriptyline hydrochloride particles by spray freeze drying

Preparation and characterization of nano amitriptyline hydrochloride particles by spray freeze drying Hu Y, Ma C, Sun M, Guo C, Shen J, Wang J, Nie F, Gao B. Abstract Aim: To investigate the enhancement of bioavailability by the usage of drug nanoparticles for increasing the efficacy of antidepressant therapeutic value. Materials & methods: Nano-amitriptyline HCI… Continue reading Preparation and characterization of nano amitriptyline hydrochloride particles by spray freeze drying

Atmospheric spray freeze drying of sugar solution with phage D29

Atmospheric spray freeze drying of sugar solution with phage D29 Alvin Ly, Nicholas B. Carrigy, Hui Wang, Melissa Harrison, Dominic Sauvageau, Andrew R Martin, Reinhard Vehring, Warren H Finlay Abstract Therapeutic bacteriophages offer a potential alternative approach in the treatment of drug resistant bacteria. In the present study, we examine the ability of atmospheric spray… Continue reading Atmospheric spray freeze drying of sugar solution with phage D29