Effect of freeze drying and spray drying on physical properties, morphology and in vitro release kinetics of vitamin D3 nanoparticles Iqra Bashir, Sajad Mohd Wani, Auqib Ahmad Bhat, Akhtar Ali Khan, Syed Zameer Hussain, Shaiq Ahmad Ganai, Nadira Anjum Abstract Encapsulation is a viable and effective technique for protection and stability of vitamin D3 during processing. In the present experiment, the effect of ultrasonication on encapsulation of vitamin D3 using… Continue reading Effect of freeze drying and spray drying on physical properties, morphology and in vitro release kinetics of vitamin D3 nanoparticles
Tag: spray freeze drying
Spray freeze drying – A synergistic drying technology and its applications in the food industry to preserve bioactive compounds
Spray freeze drying – A synergistic drying technology and its applications in the food industry to preserve bioactive compounds Nisha Chhabra, Mehak Arora, Diksha Garg, Mahesh Kumar Samota Abstract In the food industry, drying is a crucial unit process for extending product shelf life. Many methods are available for drying of foods but spray drying and freeze drying have been widely adopted… Continue reading Spray freeze drying – A synergistic drying technology and its applications in the food industry to preserve bioactive compounds
Spray freeze drying as a novel drying process for the formulation of probiotic powders containing Lacticaseibacillus rhamnosus GG
Spray freeze drying as a novel drying process for the formulation of probiotic powders containing Lacticaseibacillus rhamnosus GG A. Steegmans, M. Plitzko, B. Luy, S. Lebeer, F. Kiekens Abstract Spray freeze drying was evaluated as a drying process for the formulation and stabilization of probiotic powders This technology combines spray freezing into cold vapour followed by rotational bulk freeze drying, and was investigated to combine the… Continue reading Spray freeze drying as a novel drying process for the formulation of probiotic powders containing Lacticaseibacillus rhamnosus GG
Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying
Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying Koki Ogawa, Otowa Aikawa, Tatsuaki Tagami, Takaaki Ito, Kohei Tahara, Shigeru Kawakami, Tetsuya Ozeki Abstract AbstractA powder formulation for mucosal administration of mRNA-encapsulated lipid nanoparticles (mRNA-LNPs) is expected to be useful for respiratory diseases. Although freeze-drying is widely used to obtain solid formulations of mRNA-LNPs, highly hydrosoluble cryoprotectants, such as sucrose are necessary. However, sucrose is not… Continue reading Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying
Spray Freeze Drying of Biologics: A Review and Applications for Inhalation Delivery
Spray Freeze Drying of Biologics: A Review and Applications for Inhalation Delivery Susana Farinha, João V Sá, Paulo Roque Lino, Marco Galésio, João Pires, Miguel Ângelo Rodrigues, João Henriques Abstract Biopharmaceuticals have established an indisputable presence in the pharmaceutical pipeline, enabling highly specific new therapies. However, manufacturing, isolating, and delivering these highly complex molecules to… Continue reading Spray Freeze Drying of Biologics: A Review and Applications for Inhalation Delivery
Granulation of fine eggshell powder to produce feedstock powder for binder jetting additive manufacturing: A feasibility study
Granulation of fine eggshell powder to produce feedstock powder for binder jetting additive manufacturing: A feasibility study Shakil Arman, Fahim Khan, Mostafa Meraj Pasha, Jackson Sanders, Zhijian Pei Abstract This paper explores the feasibility of granulating fine eggshell powder using spray freeze drying to produce feedstock powder for binder jetting additive manufacturing. Fine eggshell powder possesses carbon-capture potential but exhibits poor flowability, causing issues during powder spreading in binder jetting additive… Continue reading Granulation of fine eggshell powder to produce feedstock powder for binder jetting additive manufacturing: A feasibility study
Dry powder formulation of plasmid DNA and siRNA for inhalation
Dry powder formulation of plasmid DNA and siRNA for inhalation Chow MY, Lam JK Abstract Nucleic acid therapeutics has huge potential for the treatment of a wide range of diseases including respiratory diseases. Plasmid DNA (pDNA) and small interfering RNA (siRNA) are the two most widely investigated nucleic acids for therapeutic development. However, efficient and… Continue reading Dry powder formulation of plasmid DNA and siRNA for inhalation
Dry powder inhaler formulation of high-payload antibiotic nanoparticle complex intended for bronchiectasis therapy: Spray drying versus spray freeze drying preparation
Dry powder inhaler formulation of high-payload antibiotic nanoparticle complex intended for bronchiectasis therapy: Spray drying versus spray freeze drying preparation Yu H, Teo J, Chew JW, Hadinoto K Abstract Inhaled nano-antibiotics have recently emerged as the promising bronchiectasis treatment attributed to the higher and more localized antibiotic exposure generated compared to native antibiotics. Antibiotic nanoparticle… Continue reading Dry powder inhaler formulation of high-payload antibiotic nanoparticle complex intended for bronchiectasis therapy: Spray drying versus spray freeze drying preparation
Spray Freeze-Drying as an Alternative to the Ionic Gelation Method to Produce Chitosan and Alginate Nano-Particles Targeted to the Colon
Spray Freeze-Drying as an Alternative to the Ionic Gelation Method to Produce Chitosan and Alginate Nano-Particles Targeted to the Colon Gamboa A, Araujo V, Caro N, Gotteland M, Abugoch L, Tapia C Abstract Chitosan and alginate nano-composite (NP) carriers intended for colonic delivery containing prednisolone and inulin were obtained by two processes. Spray freeze-drying using… Continue reading Spray Freeze-Drying as an Alternative to the Ionic Gelation Method to Produce Chitosan and Alginate Nano-Particles Targeted to the Colon
Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders
Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders Maria Malamatari, Satyanarayana Somavarapu, Kevin M.G. Taylor & Graham Buckton Abstract Introduction: Nanosuspensions combine the advantages of nanotherapeutics (e.g. increased dissolution rate and saturation solubility) with ease of commercialisation. Transformation of nanosuspensions to solid oral and inhalable dosage forms minimises… Continue reading Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders