Category: Scientific papers

Inert particles as process aid in spray-freeze drying Fan Zhang, Xiaoyu Ma, Xiusheng Wu, Qing Xu, Wei Tian, Zhanyong Li Abstract Spray-freeze drying (SFD) is a novel and advanced drying technology in the production of high-value foods and pharmaceuticals. However, long drying time is still a disadvantage for the SFD applications. This constraint could be… Continue reading Inert particles as process aid in spray-freeze drying

Dry powder inhalation of siRNA Tobias WM Keil, Olivia Merkel Keywords Dry powder inhaler, Inhalation, Nanoparticle, siRNA, Spray drying, Spray freeze drying

Development of Inhalable Dry Gene Powders for Pulmonary Drug Delivery by Spray-Freeze-Drying Edina Vranic, Merima Sirbubalo, Amina Tucak, Jasmina Hadžiabdić, Ognjenka Rahić, Alisa Elezovic Abstract There is considerable potential for pulmonary gene therapy as a treatment for a number of conditions for which current treatment is inadequate. Delivering genes directly to the lungs by dry… Continue reading Development of Inhalable Dry Gene Powders for Pulmonary Drug Delivery by Spray-Freeze-Drying

Establishment of evaluation method for gene-silencing by serial pulmonary administration of siRNA and pDNA powders: Naked siRNA inhalation powder suppresses luciferase gene expression in lung Takaaki Ito, Tomoyuki Okuda, Ryo Takayama, Hirokazu Okamoto Abstract In order to evaluate the in vivo effect of inhaled formulations, it is a gold standard to create a lung metastasis… Continue reading Establishment of evaluation method for gene-silencing by serial pulmonary administration of siRNA and pDNA powders: Naked siRNA inhalation powder suppresses luciferase gene expression in lung

Numerical analysis of in-flight freezing droplets: Application to novel particle engineering technology Andrew Tait, Jonathan G.M. Lee, Bruce R.Williams, Gary A. Montague Abstract The freezing of a stream of free-falling monodispersed droplets was simulated through the development of numerical models in this work. Prediction of the freezing time and temperature transition of a single droplet… Continue reading Numerical analysis of in-flight freezing droplets: Application to novel particle engineering technology

Fabrication of three-dimensional TKX-50 network-like nanostructures by liquid nitrogen-assisted spray freeze-drying method Xiong Cao, Yiping Shang, Kejuan Meng, Guodong Yue, Liyuan Yang, Yang Liu, Peng Deng, Lishuang Hu Abstract Design and fabrication of micro- and nanostructures for energetic materials have attracted more attention recently to improve safety properties and enhance detonation performance. Exploring and developing… Continue reading Fabrication of three-dimensional TKX-50 network-like nanostructures by liquid nitrogen-assisted spray freeze-drying method

Can spray freeze-drying improve the re-dispersion of crystalline nanoparticles of pure naproxen? Veronika Braig, Christoph Konnerth, Wolfgang Peukert, Geoffrey Lee Abstract Spray freeze drying (SFD) was used to prepare re-dispersible powders of crystalline, pure-drug nanodispersions of naproxen in lactose and stabilized with hydroxypropyl cellulose. The particle size of the rehydrated powders was determined using static… Continue reading Can spray freeze-drying improve the re-dispersion of crystalline nanoparticles of pure naproxen?

Oral immunization with bacteriophage MS2-L2 VLPs protects against oral and genital infection with multiple HPV types associated with head & neck cancers and cervical cancer Lukai Zhai, Rashi Yadav, Nitesh K. Kunda, Dana Anderson, Elizabeth Bruckner, Elliott K. Miller, Rupsa Basu, Pavan Muttil, Ebenezer Tumban Abstract Human papillomaviruses (HPVs) are the most common sexually transmitted… Continue reading Oral immunization with bacteriophage MS2-L2 VLPs protects against oral and genital infection with multiple HPV types associated with head & neck cancers and cervical cancer

1H NMR quantification of spray dried and spray freeze-dried saccharide carriers in dry powder inhaler formulations Mai Babenko, Jean-Marie R. Peron, Waseem Kaialy, Gianpiero Calabrese, Raid G. Alany, Amr ElShaer Abstract Quantitative analysis using proton NMR (1H qNMR) has been employed in various areas such as pharmaceutical analysis (e.g., dissolution study), vaccines, natural products analysis,… Continue reading 1H NMR quantification of spray dried and spray freeze-dried saccharide carriers in dry powder inhaler formulations

Effect of skimmed milk powder concentrations on the biological characteristics of microencapsulated Saccharomyces cerevisiae by vacuum-spray-freeze-drying Lin Cao, Qinglian Xu, Yage Xing, Xunlian Guo, Wenxiu Li, Yimin Cai Abstract The effects of skimmed milk powder (SMP) concentrations on the biological characteristics of microencapsulated Saccharomyces cerevisiae prepared by employing vacuum-spray-freeze-drying (VSFD) technology are evaluated. Results show… Continue reading Effect of skimmed milk powder concentrations on the biological characteristics of microencapsulated Saccharomyces cerevisiae by vacuum-spray-freeze-drying