Category: Scientific papers

Spray freeze drying: Emerging applications in drug delivery D.A. Vishali, J. Monisha, S.K. Sivakamasundari, J.A. Moses, C. Anandharamakrishnan Abstract Spray freeze drying is relatively a recent drying technique involving heterogeneous set of steps which includes droplet formation, freezing, and sublimation. It has proven benefits over other drying methods in terms of producing products with improved… Continue reading Spray freeze drying: Emerging applications in drug delivery

Bulk Dynamic Spray Freeze-Drying Part 2: Model-Based Parametric Study for Spray-Freezing Process Characterization Israel B. Sebastião, Bakul Bhatnagar, Serguei Tchessalov, Satoshi Ohtake, Matthias Plitzko, Bernhard Luy, Alina Alexeenko Abstract Spray freeze-drying is an evolving technology that combines the benefits of spray-drying and conventional lyophilization techniques to produce drug substance and drug product as free-flowing powders.… Continue reading Bulk Dynamic Spray Freeze-Drying Part 2: Model-Based Parametric Study for Spray-Freezing Process Characterization

Bulk Dynamic Spray Freeze-Drying Part 1: Modeling of Droplet Cooling and Phase Change Israel B. Sebastião, Bakul Bhatnagar, Serguei Tchessalov, Satoshi Ohtake, Matthias Plitzko, Bernhard Luy, Alina Alexeenko Abstract In spray freeze-drying (SFD), the solution is typically dispersed into a gaseous cold environment producing frozen microparticles that are subsequently dried via sublimation. This technology can… Continue reading Bulk Dynamic Spray Freeze-Drying Part 1: Modeling of Droplet Cooling and Phase Change

Micro and nano encapsulation, retention and controlled release of flavor and aroma compounds: A critical review Md. Saifullah, Mohammad Rezaul Islam Shishir, Rayhana Ferdowsi, Md Ramim Tanver Rahman, Quan Van Vuong Abstract Background Encapsulation of flavor and aroma in an appropriate form is an important concern for a long time. Encapsulation is the most successful… Continue reading Micro and nano encapsulation, retention and controlled release of flavor and aroma compounds: A critical review

Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition Liao Q, Yip L, Chow MYT, Chow SF, Chan HK, Kwok PCL, Lam JKW Abstract Systemic administration of antifungal agents for the treatment of pulmonary aspergillosis is limited by the poor lung deposition and severe adverse… Continue reading Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition

Fabrication of homogenous pellets by freeze granulation of optimized TiO2-Y2O3 suspensions F. La Lumia, L. Ramond, C. Pagnoux, G. Bernard-Granger Abstract MOX fuels are used in nuclear reactors. To ensure the manufacture of MOX, wet processes are investigated. Freeze granulation of water-based powder suspension seems a promising way to yield homogenous and easy-to-press UO2-PuO2 granules.… Continue reading Fabrication of homogenous pellets by freeze granulation of optimized TiO2-Y2O3 suspensions

Supporting data and methods for the multi-scale modelling of freeze-drying of microparticles in packed-beds Luigi C. Capozzi, Antonello A. Barresi, Roberto Pisano Abstract A multi-scale approach can be used to simulate the drying behavior of microparticles in packed-bed. Data outcomes from discrete element method (DEM) and computational fluid dynamics (CFD) simulations can be used to… Continue reading Supporting data and methods for the multi-scale modelling of freeze-drying of microparticles in packed-beds

Cryogenic Fabrication of Dry Powders to Enhance the Solubility of a Promising Anticancer Drug, SHetA2, for Oral Administration Ibrahim M, Hatipoglu MK, Garcia-Contreras L Abstract SHetA2 is a novel anticancer drug with poor aqueous solubility. In formal toxicological studies, Kolliphor HS 15 was used as a solubilizing agent to increase the oral bioavailability of SHetA2.… Continue reading Cryogenic Fabrication of Dry Powders to Enhance the Solubility of a Promising Anticancer Drug, SHetA2, for Oral Administration.

Influence of Nanoparticle Pretreatment on the Thermal, Rheological and Mechanical Properties of PLA-PBSA Nanocomposites Incorporating Cellulose Nanocrystals or Montmorillonite Wissam Abdallah, Amin Mirzadeh, Victor Tan, Musa R. Kamal Abstract Nanoparticles based on cellulose nanocrystals (CNC) and montmorillonite clay (MMT) were prepared using spray freeze-drying. The nanoparticles were then used as reinforcement to prepare nanocomposites with… Continue reading Influence of Nanoparticle Pretreatment on the Thermal, Rheological and Mechanical Properties of PLA-PBSA Nanocomposites Incorporating Cellulose Nanocrystals or Montmorillonite

Spray Freeze-Drying Technology: Enabling Flexibility of Supply Chain and Drug-Product Presentation for Biologics Deirdre Lowe, Mehak Mehta, Geetha Govindan, Kapil Gupta Abstract Biopharmaceutical drug substances (DSs) and drug products (DPs) commonly are stored frozen or refrigerated to maintain stability through long-term storage, handling, and transportation (1). Temperature excursions during storage and transport can affect product… Continue reading Spray Freeze-Drying Technology: Enabling Flexibility of Supply Chain and Drug-Product Presentation for Biologics