Category: Scientific papers

Fabrication of transparent MgAl2O4 spinel via spray freeze drying of microfluidized slurry Ha-Neul Kim, Jin-Myung Kim, Mi-Ju Kim, Jae-Woong Ko, Young-Jo Park, Kisu Lee, Doo Hyun Choi Abstract Spherical granules were prepared from a monodispersed slurry by combining the microfluidization (MF) method and the spray freeze-drying (SFD) process. Starting with the prepared granules, transparent MgAl2O4… Continue reading Fabrication of transparent MgAl2O4 spinel via spray freeze drying of microfluidized slurry

Large porous particles for respiratory drug delivery. Glycine-based formulations A.G. Ogienko, E.G. Bogdanova, N.A. Trofimov, S.A. Myz, A.A. Ogienko, B.A. Kolesov, A.S. Yunoshev, N.V. Zubikov, A.Yu. Manakov, V.V. Boldyrev, E.V. Boldyreva Abstract Large porous particles are becoming increasingly popular as carriers for pulmonary drug delivery with both local and systemic applications. These particles have high… Continue reading Large porous particles for respiratory drug delivery. Glycine-based formulations

Review on novel granulation techniques Nayan Patil, S. C. Khadse, P. P. Ige Abstract Tablets are the generally use dosage form, suitable to long-suffering observance, stretch in dose routine as well as design of dosage form. Pharmaceutical tablets be process every one in excess of the humanity use direct-compression, wet and dry granulation. The process… Continue reading Review on novel granulation techniques

Novel Budesonide Particles for Dry Powder Inhalation Prepared Using a Microfluidic Reactor Coupled With Ultrasonic Spray Freeze Drying Saboti D, Maver U, Chan HK, Planinšek O Abstract Budesonide (BDS) is a potent active pharmaceutical ingredient, often administered using respiratory devices such as metered dose inhalers, nebulizers, and dry powder inhalers. Inhalable drug particles are conventionally… Continue reading Novel Budesonide Particles for Dry Powder Inhalation Prepared Using a Microfluidic Reactor Coupled With Ultrasonic Spray Freeze Drying.

Effect of the solvent composition and annealing process on the preparation of spray freeze-dried acetaminophen powder Jae-Young Her, Kwang-Geun Lee Abstract The analgesic and physical properties of acetaminophen powder suitable as an inhaled drug produced by spray freeze-drying (SFD) were compared with those of raw acetaminophen. A laser particle size analyzer and scanning electron microscopy… Continue reading Effect of the solvent composition and annealing process on the preparation of spray freeze-dried acetaminophen powder

Spray freeze granulation of submicrometre α-alumina using ultrasonicati S. Ghanizadeh, P. Ramanujam, B. Vaidhyanathan, J. Binner Abstract Granulation is a key factor towards improvement of the flowability of fine ceramic powders to make them suitable for industrial dry pressing. Controlled granulation of fine alumina particles with a primary particle size of ∼ 150 nm was… Continue reading Spray freeze granulation of submicrometre α-alumina using ultrasonicati

Effect of freeze-drying treatment on the optical properties of SPS-sintered alumina M. Suárez, A. Fernández, J.L. Menéndez, M. Nygren, R. Torrecillas, Z. Zhao Abstract This study looks at the influence of alumina powder processing on the preparation of transparent alumina by Spark Plasma Sintering (SPS). Zeta potential measurements were carried out on alumina suspensions in… Continue reading Effect of freeze-drying treatment on the optical properties of SPS-sintered alumina

Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars W.F. Tonnis, J.-P. Amorij, M.A. Vreeman, H.W. Frijlink, G.F. Kersten, W.L.J. Hinrichs Abstract The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2–8 °C). This dependence on a cold-chain is highly challenging in areas… Continue reading Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars

Encapsulation of antigen-loaded silica nanoparticles into microparticles for intradermal powder injection Yibin Deng, Roman Mathaes, Gerhard Winter, Julia Engert Abstract Epidermal powder immunisation (EPI) is being investigated as a promising needle-free delivery methods for vaccination. The objective of this work was to prepare a nanoparticles-in-microparticles (nano-in-micro) system, integrating the advantages of nanoparticles and microparticles into… Continue reading Encapsulation of antigen-loaded silica nanoparticles into microparticles for intradermal powder injection

Fostering the properties of Zr0.8Sn0.2TiO4 (ZST) ceramics via freeze granulation without sintering additives S. M. Olhero, Ajay Kaushal and J. M. F. Ferreira Abstract The present paper reports the overall benefits of freeze granulation for enhancing the properties of zirconium tin titanate Zr0.8Sn0.2TiO4 (ZST) ceramics in the total absence of sintering additives. The ZST powder… Continue reading Fostering the properties of Zr0.8Sn0.2TiO4 (ZST) ceramics via freeze granulation without sintering additives