Category: Scientific papers

Can spray freeze-drying improve the re-dispersion of crystalline nanoparticles of pure naproxen? Veronika Braig, Christoph Konnerth, Wolfgang Peukert, Geoffrey Lee Abstract Spray freeze drying (SFD) was used to prepare re-dispersible powders of crystalline, pure-drug nanodispersions of naproxen in lactose and stabilized with hydroxypropyl cellulose. The particle size of the rehydrated powders was determined using static… Continue reading Can spray freeze-drying improve the re-dispersion of crystalline nanoparticles of pure naproxen?

Oral immunization with bacteriophage MS2-L2 VLPs protects against oral and genital infection with multiple HPV types associated with head & neck cancers and cervical cancer Lukai Zhai, Rashi Yadav, Nitesh K. Kunda, Dana Anderson, Elizabeth Bruckner, Elliott K. Miller, Rupsa Basu, Pavan Muttil, Ebenezer Tumban Abstract Human papillomaviruses (HPVs) are the most common sexually transmitted… Continue reading Oral immunization with bacteriophage MS2-L2 VLPs protects against oral and genital infection with multiple HPV types associated with head & neck cancers and cervical cancer

1H NMR quantification of spray dried and spray freeze-dried saccharide carriers in dry powder inhaler formulations Mai Babenko, Jean-Marie R. Peron, Waseem Kaialy, Gianpiero Calabrese, Raid G. Alany, Amr ElShaer Abstract Quantitative analysis using proton NMR (1H qNMR) has been employed in various areas such as pharmaceutical analysis (e.g., dissolution study), vaccines, natural products analysis,… Continue reading 1H NMR quantification of spray dried and spray freeze-dried saccharide carriers in dry powder inhaler formulations

Effect of skimmed milk powder concentrations on the biological characteristics of microencapsulated Saccharomyces cerevisiae by vacuum-spray-freeze-drying Lin Cao, Qinglian Xu, Yage Xing, Xunlian Guo, Wenxiu Li, Yimin Cai Abstract The effects of skimmed milk powder (SMP) concentrations on the biological characteristics of microencapsulated Saccharomyces cerevisiae prepared by employing vacuum-spray-freeze-drying (VSFD) technology are evaluated. Results show… Continue reading Effect of skimmed milk powder concentrations on the biological characteristics of microencapsulated Saccharomyces cerevisiae by vacuum-spray-freeze-drying

Spray freeze drying: Emerging applications in drug delivery D.A. Vishali, J. Monisha, S.K. Sivakamasundari, J.A. Moses, C. Anandharamakrishnan Abstract Spray freeze drying is relatively a recent drying technique involving heterogeneous set of steps which includes droplet formation, freezing, and sublimation. It has proven benefits over other drying methods in terms of producing products with improved… Continue reading Spray freeze drying: Emerging applications in drug delivery

Bulk Dynamic Spray Freeze-Drying Part 2: Model-Based Parametric Study for Spray-Freezing Process Characterization Israel B. Sebastião, Bakul Bhatnagar, Serguei Tchessalov, Satoshi Ohtake, Matthias Plitzko, Bernhard Luy, Alina Alexeenko Abstract Spray freeze-drying is an evolving technology that combines the benefits of spray-drying and conventional lyophilization techniques to produce drug substance and drug product as free-flowing powders.… Continue reading Bulk Dynamic Spray Freeze-Drying Part 2: Model-Based Parametric Study for Spray-Freezing Process Characterization

Bulk Dynamic Spray Freeze-Drying Part 1: Modeling of Droplet Cooling and Phase Change Israel B. Sebastião, Bakul Bhatnagar, Serguei Tchessalov, Satoshi Ohtake, Matthias Plitzko, Bernhard Luy, Alina Alexeenko Abstract In spray freeze-drying (SFD), the solution is typically dispersed into a gaseous cold environment producing frozen microparticles that are subsequently dried via sublimation. This technology can… Continue reading Bulk Dynamic Spray Freeze-Drying Part 1: Modeling of Droplet Cooling and Phase Change

Micro and nano encapsulation, retention and controlled release of flavor and aroma compounds: A critical review Md. Saifullah, Mohammad Rezaul Islam Shishir, Rayhana Ferdowsi, Md Ramim Tanver Rahman, Quan Van Vuong Abstract Background Encapsulation of flavor and aroma in an appropriate form is an important concern for a long time. Encapsulation is the most successful… Continue reading Micro and nano encapsulation, retention and controlled release of flavor and aroma compounds: A critical review

Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition Liao Q, Yip L, Chow MYT, Chow SF, Chan HK, Kwok PCL, Lam JKW Abstract Systemic administration of antifungal agents for the treatment of pulmonary aspergillosis is limited by the poor lung deposition and severe adverse… Continue reading Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition

Fabrication of homogenous pellets by freeze granulation of optimized TiO2-Y2O3 suspensions F. La Lumia, L. Ramond, C. Pagnoux, G. Bernard-Granger Abstract MOX fuels are used in nuclear reactors. To ensure the manufacture of MOX, wet processes are investigated. Freeze granulation of water-based powder suspension seems a promising way to yield homogenous and easy-to-press UO2-PuO2 granules.… Continue reading Fabrication of homogenous pellets by freeze granulation of optimized TiO2-Y2O3 suspensions