Category: Scientific papers

Cryogenic Fabrication of Dry Powders to Enhance the Solubility of a Promising Anticancer Drug, SHetA2, for Oral Administration Ibrahim M, Hatipoglu MK, Garcia-Contreras L Abstract SHetA2 is a novel anticancer drug with poor aqueous solubility. In formal toxicological studies, Kolliphor HS 15 was used as a solubilizing agent to increase the oral bioavailability of SHetA2.… Continue reading Cryogenic Fabrication of Dry Powders to Enhance the Solubility of a Promising Anticancer Drug, SHetA2, for Oral Administration.

Influence of Nanoparticle Pretreatment on the Thermal, Rheological and Mechanical Properties of PLA-PBSA Nanocomposites Incorporating Cellulose Nanocrystals or Montmorillonite Wissam Abdallah, Amin Mirzadeh, Victor Tan, Musa R. Kamal Abstract Nanoparticles based on cellulose nanocrystals (CNC) and montmorillonite clay (MMT) were prepared using spray freeze-drying. The nanoparticles were then used as reinforcement to prepare nanocomposites with… Continue reading Influence of Nanoparticle Pretreatment on the Thermal, Rheological and Mechanical Properties of PLA-PBSA Nanocomposites Incorporating Cellulose Nanocrystals or Montmorillonite

Spray Freeze-Drying Technology: Enabling Flexibility of Supply Chain and Drug-Product Presentation for Biologics Deirdre Lowe, Mehak Mehta, Geetha Govindan, Kapil Gupta Abstract Biopharmaceutical drug substances (DSs) and drug products (DPs) commonly are stored frozen or refrigerated to maintain stability through long-term storage, handling, and transportation (1). Temperature excursions during storage and transport can affect product… Continue reading Spray Freeze-Drying Technology: Enabling Flexibility of Supply Chain and Drug-Product Presentation for Biologics

Pharmaceutical Freeze Drying Technology 2018 Overview Although an old process, pharmaceutical freeze drying is ever evolving with new trends and approaches being used for pharmaceutical formulation. In it’s 6th year, the conference will cover the most recent advances in Freeze drying technology and discuss the latest ideas in the industry. It is the perfect platform… Continue reading Pharmaceutical Freeze Drying Technology 2018

Spray-freeze-drying: A novel process for the drying of foods and bioproducts S. Padma Ishwarya, C. Anandharamakrishnan, Andrew G.F. Stapley Abstract Spray-freeze-drying (SFD) is an unconventional freeze drying technique that produces uniquely powdered products whilst still including the benefits of conventionally freeze dried products. SFD has potential applications in high value products due to its edge… Continue reading Spray-freeze-drying: A novel process for the drying of foods and bioproducts

Comparison of Freeze and Spray Drying to Obtain Primaquine-Loaded Solid Lipid Nanoparticles Owuor James, Florence Oloo, Japheth Kibet Ngetich, Mwaiwa Kivunzya Abstract This article describes how the spray drying and freeze drying of various nanosized Solid Lipid Nanoparticle (SLN) and the physicochemical attributes of the acquired particles were examined. Primaquine loaded Solid Lipid Nanoparticles dried… Continue reading Comparison of Freeze and Spray Drying to Obtain Primaquine-Loaded Solid Lipid Nanoparticles

Thermal inactivation kinetics of microencapsulated microbial transglutaminase by ultrasonic spray-freeze drying Hilal Isleroglu, Izzet Turker Abstract Partially purified microbial transglutaminase (mTG) was microencapsulated by ultrasonic spray-freeze drying (USFD) as a novel method, using a 48 kHz ultrasonic nozzle. The microencapsulated samples, which used a mixture of inulin and gum arabic as coating materials, were compared to… Continue reading Thermal inactivation kinetics of microencapsulated microbial transglutaminase by ultrasonic spray-freeze drying

Innovative synthesis of nanostructured composite materials by a spray-freeze drying process: Efficient catalysts and photocatalysts preparation Alice Lolli, Magda Blosi, Simona Ortelli, Anna Luisa Costa, Ilaria Zanoni, Danilo Bonincontro, Francesca Carella, Stefania Albonetti Abstract The spray-freeze-drying (SFD) approach was successfully applied for the preparation of nanostructured porous mixed oxides with high surface area. The preparation… Continue reading Innovative synthesis of nanostructured composite materials by a spray-freeze drying process: Efficient catalysts and photocatalysts preparation

Membrane‐Freeze Concentration Hybrid for Temperature‐Sensitive Biomolecules. Investigation, Application, and Techno‐Economic Benefits Timo van Beek, Michael Budde, Jan van Esch Abstract In order to close the technology gap between membrane technologies and spray/freeze‐drying ideally with a technology that avoids thermal stress to sensitive enzyme solutions, the limits of freeze concentration for this application have been investigated.… Continue reading Membrane‐Freeze Concentration Hybrid for Temperature‐Sensitive Biomolecules. Investigation, Application, and Techno‐Economic Benefits

How different nanoparticles affect the rheological properties of aqueous Wyoming sodium bentonite suspensions Abstract Clay suspensions present complex microstructures in different environments and deep understanding of such microstructures is crucial to control their flow properties. Their rheological profile is closely linked with the structural association (3-D network) of bentonite particles. Nanomaterials are considered very good… Continue reading How different nanoparticles affect the rheological properties of aqueous Wyoming sodium bentonite suspensions