Category: Scientific papers

Synthesized nano particles of glimepiride via spray freezing into cryogenic liquid: characterization, antidiabetic activity, and bioavailability Dalia A Gaber, Abdulrahman S Alhuwaymili, Hessah S Alhawas, Alhnouf A Almutiri, Amal M Alsubaiyel, Siham A Abdoun, Reem A Almutairi Abstract The aim of this work was to formulate glimepiride (class II drug) which is characterized by low… Continue reading Synthesized nano particles of glimepiride via spray freezing into cryogenic liquid: characterization, antidiabetic activity, and bioavailability

Ultrasonic spray freeze-drying of sucrose and mannitol-based formulations: Impact of the atomization conditions on the particle morphology and drying performance Merve B. Adali, Antonello Barresi, Gianluca Boccardo, Giorgia Montalbano, Roberto Pisano Abstract Spray freeze-drying is an emerging manufacturing technology that offers many advantages, including long-term stability, consistent particle size distribution, and enhanced bioavailability. However, its… Continue reading Ultrasonic spray freeze-drying of sucrose and mannitol-based formulations: Impact of the atomization conditions on the particle morphology and drying performance

Spray freeze drying to solidify Nanosuspension of Cefixime into inhalable microparticles Samaneh Alaei, Elham Ghasemian, Alireza Vatanara Abstract Size reduction to a nanoscale is a relatively new approach to overcome solubility and bioavailability issues of many drugs such as cefixime (CFX). However, nanoparticles and specifically nanosuspensions are prone to many instabilities like aggregation and sedimentation.… Continue reading Spray freeze drying to solidify Nanosuspension of Cefixime into inhalable microparticles

Optimization of spray freeze drying parameters for spark plasma sintering of transparent MgAl2O4 spinel Aref Basiri, Amir Hossein, Nassajpour-Esfahani, Mohammad Reza, Haftbaradaran-Esfahani, Amir Alhaji, Ali Shafyei Abstract Magnesium aluminate spinel (MgAl2O4) is considered as one of the most important spinels possessing desirable mechanical properties, with a wide range of applications at high temperatures. Powder granulation… Continue reading Optimization of spray freeze drying parameters for spark plasma sintering of transparent MgAl2O4 spinel

Polyphosphates as an effective vehicle for delivery of bioavailable nanoparticulate iron(III) Shiyang Li, Tengjiao Guo, Wei Guo, Xuan Cui, Mingyong Zeng, Haohao Wu Abstract Polyphosphates are widely used food additives with the potential to increase iron bioavailability but chemical nature of their soluble complexes with iron remains largely unknown. Here, pyrophosphate, tripolyphosphate, hexametaphosphate and ∼25-chain-length… Continue reading Polyphosphates as an effective vehicle for delivery of bioavailable nanoparticulate iron(III)

Identification of Stability Constraints in the Particle Engineering of an Inhaled Monoclonal Antibody Dried Powder Ashlee D Brunaugh, Li Ding, Tian Wu, Michael Schneider, Ryan Khalaf, Hugh D C Smyth Abstract Monoclonal antibody (mAb) based therapies may provide a valuable new treatment modality for acute and chronic lung diseases, including asthma, respiratory infections, and lung… Continue reading Identification of Stability Constraints in the Particle Engineering of an Inhaled Monoclonal Antibody Dried Powder

Spray-freeze-dried inhalable composite microparticles containing nanoparticles of combinational drugs for potential treatment of lung infections caused by Pseudomonas aeruginosa Shihui Yu, XiaohuiPu, Maizbha Uddin Ahmed, Heidi H.Yu, Tarun Tejasvi Mutukuri, Jian Li, Qi Tony Zhou Abstract The multi-drug resistance of Pseudomonas aeruginosa is an overwhelming cause of terminal and persistent lung infections in cystic fibrosis… Continue reading Spray-freeze-dried inhalable composite microparticles containing nanoparticles of combinational drugs for potential treatment of lung infections caused by Pseudomonas aeruginosa

Freeze granulation and spray drying of mixed granules of Al2O3 M. Singlard, A. Paillassa, L. Ferres, C. Pagnoux, A. Aimable Abstract This paper proposes a comparative study of two techniques of granulation of a submicronic alumina powder with high binder content slurries, by spray drying and freeze granulation for the preparation of mixed granules. First,… Continue reading Freeze granulation and spray drying of mixed granules of Al2O3

Freeze Granulation of Nanoporous UiO-66 Nanoparticles for Capture of Volatile Organic Compounds Van Nhieu Le, Daekeun Kim, Jinsoo Kim, Mohd Roslee Othman Abstract Nanoporous UiO-66 spherical beads prepared by using PVA binder successfully connected UiO-66 nanoparticles together into granular beads with improved mechanical strength for toluene capture. This was achieved without affecting the crystalline nature… Continue reading Freeze Granulation of Nanoporous UiO-66 Nanoparticles for Capture of Volatile Organic Compounds

Maximizing the enzyme immobilization of enzymatic glucose biofuel cells through hierarchically structured reduced graphene oxide Joonyoung Lee, Kyuhwan Hyun, Jae Min Park, Ho Seok Park, Yongchai Kwon Summary The number of immobilized glucose oxidase (GOx) molecules is considerably increased by the structural modification of reduced graphene oxide (rGO), and the performance of enzymatic biofuel cells… Continue reading Maximizing the enzyme immobilization of enzymatic glucose biofuel cells through hierarchically structured reduced graphene oxide