Category: Scientific papers

Improvement of Drug Delivery Properties of Risperidone via Preparation of Oral Disintegration Tablet Containing Nanostructured Microparticles Motahare salarvanda, Zeinab Aref Darabi, Vahid Ramezani Abstract Introduction: The aim of this study was to improve the dissolution profile of risperidone and increase the compliance of psychotic patients through the design of an oral disintegration tablet­ (ODT) of… Continue reading Improvement of Drug Delivery Properties of Risperidone via Preparation of Oral Disintegration Tablet Containing Nanostructured Microparticles

Post-Processing Techniques for the Improvement of Liposome Stability Ji Young Yu, Piyanan Chuesiang, Gye Hwa Shin, Hyun Jin Park Abstract Liposomes have been utilized as a drug delivery system to increase the bioavailability of drugs and to control the rate of drug release at the target site of action. However, the occurrence of self-aggregation, coalescence,… Continue reading Post-Processing Techniques for the Improvement of Liposome Stability

Influence of the PuO2 content on the sintering behaviour of UO2-PuO2 freeze-granulated powders under reducing conditions Julie Simeon, Florent Lebreton, Laure Ramond, Nicolas Clavier, Guillaume Bernard-Granger Abstract The sintering behaviour of freeze-granulated UO2-PuO2 powders containing 33 and 15 mol% Pu/(U + Pu) was investigated under reducing conditions up to 1700 °C. For both compositions, the… Continue reading Influence of the PuO2 content on the sintering behaviour of UO2-PuO2 freeze-granulated powders under reducing conditions

Mixed bacteriophage ms2-l2 vlps elicit long-lasting protective antibodies against hpv pseudovirus 51 Abstract Three prophylactic vaccines are approved to protect against HPV infections. These vaccines are highly immunogenic. The most recent HPV vaccine, Gardasil-9, protects against HPV types associated with ~90% of cervical cancer (worldwide). Thus, ~10% of HPV-associated cancers are not protected by Gardasil-9.… Continue reading Mixed bacteriophage ms2-l2 vlps elicit long-lasting protective antibodies against hpv pseudovirus 51

Spray freeze dried lyospheres® for nasal administration of insulin Tuğrul Mert Serim, Jan Kožák, Annika Rautenberg, Ayşe Nurten Özdemir, Yann Pellequer, Alf Lamprecht Abstract Pharmacologically active macromolecules, such as peptides, are still a major challenge in terms of designing a delivery system for their transport across absorption barriers and at the same time provide sufficiently… Continue reading Spray freeze dried lyospheres® for nasal administration of insulin

Intratracheal inoculation of AHc vaccine induces protection against aerosolized botulinum neurotoxin A challenge in mice. Changjiao Gan, Wenbo Luo, Yunzhou Yu, Zhouguang Jiao, Sha Li, Duo Su, Junxia Feng, Xiaodong Zhao, Yefeng Qiu, Lingfei Hu, Dongsheng Zhou, Xiaolu Xiong, Jinglin Wang & Huiying Yang Abstract Botulinum neurotoxin (BoNT), produced by Clostridium botulinum, is generally known… Continue reading Intratracheal inoculation of AHc vaccine induces protection against aerosolized botulinum neurotoxin A challenge in mice.

Inhaled Dry Powder Formulation of Tamibarotene, a Broad-Spectrum Antiviral against Respiratory Viruses Including SARS-CoV-2 and Influenza Virus Qiuying Liao, Shuofeng Yuan, Jianli Cao, Kaiming Tang, Yingshan Qiu, Han Cong Seow, Rico Chi-Hang Man, Zitong Shao, Yaoqiang Huang, Ronghui Liang, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Jenny Ka-Wing Lam Abstract In response to the epidemic and pandemic… Continue reading Inhaled Dry Powder Formulation of Tamibarotene, a Broad-Spectrum Antiviral against Respiratory Viruses Including SARS-CoV-2 and Influenza Virus

Comparative Study on Compaction and Sintering Behavior of Spray and Freeze Granulated Magnesium Aluminate Spinel Powder Swathi Manivannan, Papiya Biswas, Prasenjit Barick, Sweety Kumari, Bhaskar Prasad Saha & Roy Johnson Abstract Commercially procured magnesium aluminate (MgAl2O4) spinel powder with average particle size of 300 nm and irregular morphology were spray and freeze granulated. The granules… Continue reading Comparative Study on Compaction and Sintering Behavior of Spray and Freeze Granulated Magnesium Aluminate Spinel Powder

Morphology of alumina granules obtained by spray freeze drying with twin-fluid atomization Ruslan Kuzmin, Sergey Veselov, Nina Cherkasova, Vladimir Bataev Abstract This study presents the results of the morphological dependence of alumina granules obtained by spray freeze drying (SFD) with twin-fluid atomization. It is shown that the introduction of 1-, 2- and 4-wt.% polyvinyl alcohol… Continue reading Morphology of alumina granules obtained by spray freeze drying with twin-fluid atomization

Combination of copigmentation and encapsulation strategies for the synergistic stabilization of anthocyanins Chen Tan, Younas Dadmohammadi, Michelle C. Lee, Alireza Abbaspourrad Abstract Copigmentation and encapsulation are the two most commonly used techniques for anthocyanin stabilization. However, each of these techniques by itself suffers from many challenges associated with the simultaneous achievement of color intensification and… Continue reading Combination of copigmentation and encapsulation strategies for the synergistic stabilization of anthocyanins