Category: Scientific papers

Effect of formulation and inhaler parameters on the dispersion of spray freeze dried voriconazole particles Qiuying Liao, Ivan C.H. Lam, Hinson H.S. Lin, Leon T.L. Wan, Jason C.K. Lo, Waiting Tai, Philip C.L. Kwok, Jenny K.W. Lam Abstract Spray freeze drying is a particle engineering technique that allows the production of porous particles of low… Continue reading Effect of formulation and inhaler parameters on the dispersion of spray freeze dried voriconazole particles

Evaluation of Process Conditions for Ultrasonic Spray-Freeze Drying of Transglutaminase Hilal İşleroğlu, Izzet Turker Abstract In this study, a commercial transglutaminase enzyme was dried using an ultrasonic spray freeze drying method and the effects of the process conditions were optimized to maximize the final transglutaminase activity. Accordingly, process parameters affecting enzyme activity were selected, such… Continue reading Evaluation of Process Conditions for Ultrasonic Spray-Freeze Drying of Transglutaminase

Developing spray-freeze-dried particles containing a hyaluronic acid-coated liposome–protamine–DNA complex for pulmonary inhalation Kaori Fukushige, Tatsuaki Tagami, Munekazu Naito, Eiichi Goto, Shuichi Hirai, Naoyuki Hatayama, Hiroki Yokota, Takao Yasui, Yoshinobu Baba, Tetsuya Ozeki Abstract The liposome–protamine–DNA complex (LPD) is an effective cationic carrier of various nucleic acid constructs such as plasmid DNA and small interfering RNA… Continue reading Developing spray-freeze-dried particles containing a hyaluronic acid-coated liposome–protamine–DNA complex for pulmonary inhalation

Influences of drying methods on the structural, physicochemical and antioxidant properties of exopolysaccharide from Lactobacillus helveticus MB2-1 Luyao Xiao, Yingying Li, Juanjuan Tian, Jianzhong Zhou, Qian Xu, Li Feng, Xin Rui, Xia Fan, Qiuqin Zhang, Xiaohong Chen, Mingsheng Dong, Wei Li Abstract In this study, in order to evaluate influences of different drying methods on… Continue reading Influences of drying methods on the structural, physicochemical and antioxidant properties of exopolysaccharide from Lactobacillus helveticus MB2-1

Spray-freeze-drying of coffee S. Padma Ishwarya, C. Anandharamakrishnan Abstract The suitability of Spray-Freeze-Drying (SFD) technique for soluble coffee processing was evaluated. The resultant product characteristics were compared against its spray-dried (SD) and freeze-dried (FD) counterparts. SFD and FD coffee powders exhibited a comparable aroma profile as indicated by the electronic nose analysis. SFD resulted in… Continue reading Spray-freeze-drying of coffee

Freeze Granulated Zeolites X and A for Biogas Upgrading Kritika Narang, Farid Akhtar Abstract Biogas is a potential renewable energy resource that can reduce the current energy dependency on fossil fuels. The major limitation of utilizing biogas fully in the various applications is the presence of a significant volume fraction of carbon dioxide in biogas.… Continue reading Freeze Granulated Zeolites X and A for Biogas Upgrading

Effect of encapsulation methods on the physicochemical properties and the stability of Lactobacillus plantarum (NCIM 2083) in synbiotic powders and in-vitro digestion conditions K.S. Yoha, J.A. Moses, C. Anandharamakrishnan Abstract Encapsulation of probiotic bacteria requires precise control over a range of process parameters, all of which are technique-specific. The technology of encapsulation has received considerable… Continue reading Effect of encapsulation methods on the physicochemical properties and the stability of Lactobacillus plantarum (NCIM 2083) in synbiotic powders and in-vitro digestion conditions

Spray-freezing induced multidimensional morphology tuning of assembled spherical carbon for solar-driven steam generation Da Li, Ang Li, Yaxin Chen, Guanyu Chen, Xiaohong Chen, Dexu Zhang, Haitao Zhu, Imran Ahmed Samo, Huaihe Song Abstract Carbon materials have been extensively researched as solar absorbers in the field of solar steam generation (SSG) for their full spectrum absorption,… Continue reading Spray-freezing induced multidimensional morphology tuning of assembled spherical carbon for solar-driven steam generation

Hydroxypropyl beta cyclodextrin: a water-replacement agent or a surfactant upon spray freeze-drying of IgG with enhanced stability and aerosolization Shahriar Milani, Homa Faghihi, Abdolhosein Roulholamini Najafabadi, Mohsen Amini, Hamed Montazeri, Alireza Vatanara Abstract The great potential of hydroxypropyl beta-cyclodextrin (HPßCD), as a dried-protein stabilizer, has been attributed to various mechanisms namely water-replacement, vitrification and surfactant-like… Continue reading Hydroxypropyl beta cyclodextrin: a water-replacement agent or a surfactant upon spray freeze-drying of IgG with enhanced stability and aerosolization

Application of Spray Freeze Drying to Theophylline-Oxalic Acid Cocrystal Engineering for Inhaled Dry Powder Technology Ryoma Tanaka, Yusuke Hattori, Makoto Otsuka, Kazuhide Ashizawa Abstract Spray freeze drying (SFD) produces suitable particles for the pharmaceutical formulation of dry powders used in dry powder inhalers (DPIs). However, SFD particles have large specific surface area and are partially… Continue reading Application of Spray Freeze Drying to Theophylline-Oxalic Acid Cocrystal Engineering for Inhaled Dry Powder Technology