Category: Scientific papers

Effects of drying method and excipient on the structure and physical stability of protein solids: Freeze drying vs. spray freeze drying Tarun Tejasvi Mutukuri, Nathan E. Wilson, Lynne S. Taylor, Elizabeth M. Topp, Qi Tony Zhou Abstract This study aims to determine the impacts of drying method and excipient on changes in protein structure and… Continue reading Effects of drying method and excipient on the structure and physical stability of protein solids: Freeze drying vs. spray freeze drying

A Kinetic Model for Spray-Freezing of Pharmaceuticals Abstract Spray freeze-drying (SFD), which includes spray-freezing into droplets and dynamic vacuum drying, presents a promising alternative approach to manufacture dried pharmaceuticals more efficiently than conventional vial freeze-drying. Without reliable predictive models for the SFD conditions of interest, any respective process development still relies on empirical approaches. In… Continue reading A Kinetic Model for Spray-Freezing of Pharmaceuticals

Transparent cobalt‐doped yttrium aluminum garnet (Co2+:YAG) ceramics—An innovatory fast saturable absorber Agnieszka Szysiak, Kamila Leśniewska‐Matys, Helena Węglarz, Przemysław Gołębiewski, Dariusz Podniesiński, Anna Kozłowska Abstract Highly transparent Y3Al5O12 (YAG) ceramics doped with 0.025 and 0.05 at.% Co ions were prepared for the first time by the freeze granulation process and reaction sintering. Scanning electron microscopy (SEM)… Continue reading Transparent cobalt‐doped yttrium aluminum garnet (Co2+:YAG) ceramics—An innovatory fast saturable absorber

Spray freeze granulation of submicrometre α-alumina using ultrasonication Shaghayegh Ghanizadeh, Prabhu Ramanujam, Bala Vaidhyanathan, Jon Binner Abstract Granulation is a key factor towards improvement of the flowability of fine ceramic powders to make them suitable for industrial dry pressing. Controlled granulation of fine alumina particles with a primary particle size of ∼150 nm was carried… Continue reading Spray freeze granulation of submicrometre α-alumina using ultrasonication

Photocatalytic Oxidation of HMF under Solar Irradiation: Coupling of Microemulsion and Lyophilization to Obtain Innovative TiO2-Based Materials Alessandro Allegri, Valeriia Maslova, Magda Blosi, Anna Luisa Costa, Simona Ortelli, Francesco Basile, Stefania Albonetti Abstract The photocatalytic oxidation of biomass-derived building blocks such as 5-hydroxymethylfurfural (HMF) is a promising reaction for obtaining valuable chemicals and the efficient… Continue reading Photocatalytic Oxidation of HMF under Solar Irradiation: Coupling of Microemulsion and Lyophilization to Obtain Innovative TiO2-Based Materials

Synergistic effects in oxygen evolution activity of mixed iridium-ruthenium pyrochlores Rebecca K. Pittkowski, Daniel F. Abbott, Roman Nebel, Spyridon Divanis, Emiliana Fabbri, Ivano E. Castelli, Thomas J. Schmidt, Jan Rossmeisl, Petr Krtil Abstract Pyrochlore oxides (A2B2O7) simultaneously containing iridium and ruthenium in the B-site are promising catalysts for oxygen evolution reaction (OER) in acid media.… Continue reading Synergistic effects in oxygen evolution activity of mixed iridium-ruthenium pyrochlores

Production of bromelain aerosols using spray-freeze-drying technique for pulmonary supplementation M. N. Lavanya, R. Preethi, J. A. Moses, C. Anandharamakrishnan Abstract Spray-freeze-drying (SFD) is a promising technique to produce inhalable dry powder formulations that able to retain the integrity of bioactive compounds. Therefore, in this study bromelain aerosols were developed using SFD by varying core-to-wall… Continue reading Production of bromelain aerosols using spray-freeze-drying technique for pulmonary supplementation

Fabrication and microstructure analysis of continuous C fibers reinforced SiC-Cnfs hybrid composite tubes Shaik Mubina, M. Ilaiyaraja, Asit Kumar Khanra, Bhaskar Prasad Saha Abstract The carbon nanofibers (Cnfs) dispersed SiC-Cnfs composite powder has been produced by spray freeze-granulation technique. SiC-based hybrid composite tubes (BN-Cf/SiC-Cnfs) were fabricated by systematically laying of boron nitride-coated continuous carbon fiber… Continue reading Fabrication and microstructure analysis of continuous C fibers reinforced SiC-Cnfs hybrid composite tubes

Comparison of Strategies in Development and Manufacturing of Low Viscosity, Ultra-High Concentration Formulation for IgG1 Antibody Vaibhav Deokar, Alok Sharma, Rustom Mody, Subrahmanyam M. Volety Abstract Monoclonal antibodies requiring higher doses for exerting therapeutic effect but having lower stability, are administered as dilute infusions, or as two (low concentration) injections both resulting in reduced patient… Continue reading Comparison of Strategies in Development and Manufacturing of Low Viscosity, Ultra-High Concentration Formulation for IgG1 Antibody

Targeted Pulmonary Delivery of the Green Tea Polyphenol Epigallocatechin Gallate Controls the Growth of Mycobacterium tuberculosis by Enhancing the Autophagy and Suppressing Bacterial Burden Ankur Sharma, Kalpesh Vaghasiya, Eupa Ray, Pushpa Gupta, Umesh Datta Gupta, Amit Kumar Singh, Rahul Kumar Verma Abstract Growing rates of tuberculosis (TB) superbugs are alarming, which has hampered the progress… Continue reading Targeted Pulmonary Delivery of the Green Tea Polyphenol Epigallocatechin Gallate Controls the Growth of Mycobacterium tuberculosis by Enhancing the Autophagy and Suppressing Bacterial Burden