Category: Scientific papers

Microencapsulation of High-Content Actives Using Biodegradable Silk Materials Muchun Liu, Pierre-Eric Millard, Henning Urch, Ophelie Zeyons, Douglas Findley, Rupert Konradi, Benedetto Marelli Abstract There is a compelling need across several industries to substitute non-degradable, intentionally added microplastics with biodegradable alternatives. Nonetheless, stringent performance criteria in actives’ controlled release and manufacturing at scale of emerging materials… Continue reading Microencapsulation of High-Content Actives Using Biodegradable Silk Materials

Spray freeze drying of dairy products: Effect of formulation on dispersibility Alberto Baldelli, Hale Oguzlu, Diana Yumeng Liang, Alison Subiantoro, Meng Wai Woo, Anubhav Pratap-Singh Abstract Milk powders are commonly produced by using the technique of spray drying. In this work, we propose the use of spray freeze drying technology to improve the re-dispersibility of… Continue reading Spray freeze drying of dairy products: Effect of formulation on dispersibility

Spray Freezing Coating on the Carrier Particles for Powder Preparation Qing Xu, Ruixin Wang, Fan Zhang, Ruifang Wang, Long Wu, Bo Lin Abstract Carrier particle spray freeze-drying is a new technology with high added value for thermosensitive powder spray freeze-drying. The technology includes the following steps: atomization, coating, freezing, and drying. Due to the action… Continue reading Spray Freezing Coating on the Carrier Particles for Powder Preparation

Debate: Nanoparticles – a blessing or a curse? Hans Leuenberger Abstract This chapter was inspired by Ilya Prigogine (Nobel laureate 1977) and by six axioms derived1 earlier, such as A1, Far from equilibrium conditions, favoring transformations from disorder into order leading to the creation of life, and A5 and 6, The evolutionary process uses all… Continue reading Debate: Nanoparticles – a blessing or a curse?

Spray freeze drying for protein encapsulation: Impact of the formulation to morphology and stability Alberto Baldelli, Yigong Guo, Hui Xin Ong, Aylin Cidem, Anika Singh, Daniela Traini, Anubhav Pratap-Singh Abstract Proteins, the building blocks of life, are increasingly being used as therapeutics for treating several diseases. Yet, there are challenges in the delivery of highly… Continue reading Spray freeze drying for protein encapsulation: Impact of the formulation to morphology and stability

Modulating the Pore Architecture of Ice-Templated Dextran Microparticles Using Molecular Weight and Concentration Tero Kämäräinen, Kazunori Kadota, Jun Yee Tse, Hiromasa Uchiyama, Shinya Yamanaka, Yuichi Tozuka Abstract Spray freeze drying (SFD) is an ice templating method used to produce highly porous particles with complex pore architectures governed by ice nucleation and growth. SFD particles have… Continue reading Modulating the Pore Architecture of Ice-Templated Dextran Microparticles Using Molecular Weight and Concentration

Spray freeze-drying for inhalation application: process and formulation variables Mostafa Rostamnezhad, Hossein Jafari, Farzad Moradikhah, Sara Bahrainian, Homa Faghihi, Reza Khalvati, Reza Bafkary, Alireza Vatanara Abstract High porous particles with specific aerodynamic properties were processed by the spray freeze-drying (SFD) method. Comprehensive knowledge about all aspects of the SFD method is required for particle engineering… Continue reading Spray freeze-drying for inhalation application: process and formulation variables

Fabricating high-loading ultra-small PtCu3/rGO via a traceless protectant and spray-freeze-drying method Qingyu Luo, Wei Xu, Shaolong Tang Abstract Exploring excellent catalysts for oxygen reduction reaction (ORR) with a facile and cost-effective method is desirable but remains challenging. Herein, ultra-small PtCu3 nanoparticles (ca. 2.7 nm), immobilized on reduced graphene oxide (rGO), were synthesized via a novel and… Continue reading Fabricating high-loading ultra-small PtCu3/rGO via a traceless protectant and spray-freeze-drying method

Designing highly porous amorphous celecoxib particles by spray freeze drying leads to accelerated drug absorption in-vivo Dominic Lucas, Jan Kožák, Annika Rautenberg, Claire Chrétien, Yann Pellequer, Alf Lamprecht Abstract Poorly water-soluble drugs are still a major challenge to overcome in order to achieve sufficiently high oral bioavailability. Spray freeze drying (SFD) is proposed here as… Continue reading Designing highly porous amorphous celecoxib particles by spray freeze drying leads to accelerated drug absorption in-vivo

Dual targeting powder formulation of antiviral agent for customizable nasal and lung deposition profile through single intranasal administration Han Cong Seow, Qiuying Liao, Andy T Y Lau, Susan W S Leung, Shuofeng Yuan, Jenny K W Lam Abstract Unpredictable outbreaks due to respiratory viral infections emphasize the need for new drug delivery strategies to the… Continue reading Dual targeting powder formulation of antiviral agent for customizable nasal and lung deposition profile through single intranasal administration