News on how Freeze Granulation can improve our powder properties

ECerS XIII – Universities and Institutes

ECerS XIII – Universities and Institutes – Second day at ECerS in Limoges. We can see that research groups around the world show an increasing interest in Freeze Granulation as a powder processing tool of especially nanopowders, like carbon nanotubes. The reason being as Freeze Granulation offers an easy and practical method to handle fine nanopowders and to manufacture homogeneous granules which are optimal for pressing and sintering of different materials.

Please contact us and we will further discuss the opportunities with Freeze Granulation in your powder system and read more on technology and a Granulation Test of your powder system.

ECerS XIII – Granulation of Nanoparticles

ECerS XIII – Granulation of Nanoparticles – During first day at the conference we have had interesting discussions on how Freeze Granulation can help to make homogeneous granules of, for example, Carbon Nanotubes (CNT).

ECerS XIII Conference – Limoges, France

ECerS XIII Conference – Limoges, France – Welcome to PowderPro’s stand No 1 at the exhibition at ECerS XIII Conference (European Ceramic Society) in Limoges, France from the 23rd to the 27th of June 2013. We look forward to meet customers, partners and new contacts for interesting discussions in our stand!

We plan to have our equipment available at a nearby lab for you to see the process of Freeze Granulation.

Please contact us and we will further discuss the opportunities with Freeze Granulation in your powder system and read more on technology and a Granulation Test of your powder system.

Synthetic diamond powder granulation

Homogeneous diamond tools by Freeze Granulation

Synthetic diamond powder granulation by Freeze Granulation is today being used for to make homogeneous granules for diamond tools with long tool-life and optimal performance.

Please contact us and we will further discuss the opportunities with Freeze Granulation in your powder system and read more on technology and a Granulation Test of your powder system.

Synthetic diamond powder granulation

Thermally sensitive nanoparticles

Freeze Granulation of thermally sensitive nanoparticles

By using Freeze Granulation, spray freeze drying (SFD), you can produce dry-powder aggregates of thermally sensitive nanoparticles. Dry powder inhaler (DPI) delivery of therapeutic nanoparticles requires the nanoparticles to be transformed into inhalable micro-scale aggregate structures (i.e. nano-aggregates). With Freeze Granulation you will be able to optimize the aerosolization efficiency of the nano-aggregates, while keeping the morphology, production yield, flowability, and aqueous reconstitution in the desirable range.

Please contact us and we will further discuss the opportunities with Freeze Granulation in your powder system and read more on technology and a Granulation Test of your powder system.

Granule of thermally sensitive nanoparticles

Freeze Granulation of Nanomaterials on Slideshare

Please see our presentation Freeze Granulation of Nanomaterials on Slideshare.

How Freeze Granulation can improve the homogeneity of your nanomaterials and make it possible to redisperse a nanomaterial that have been dried.

Please contact us and we will further discuss the opportunities with Freeze Granulation in your powder system and read more on technology and a Granulation Test of your powder system.

Protein aerosol powders

Protein aerosol powders by Freeze Granulation

Freeze granulation, as opposed to spray drying, has been shown to produce protein particles with light and porous characteristics, which offered powders with superior aerosol performance due to favorable aerodynamic properties, suitable granulation technology for protein inhalation powders.

Please contact us and we will further discuss the opportunities with Freeze Granulation in your powder system and read more on technology and we propose a Granulation Test of your powder system.

Needle-free ballistic powder delivery

Needle-free ballistic powder delivery by applying Freeze Granulation you will be able to make microparticles with high insulin loading (nanosuspension) suitable for needle-free ballistic drug delivery. The resulting granules are homogeneous and robust with a diameter of around 50-150 µm, with a narrow size distribution and a high content of insulin.

Please contact us and we will further discuss the opportunities with Freeze Granulation on your powder system and read more on technology and we propose a Granulation Test of your powder system.

Zeolite granulation

Freeze Granulation of zeolite materials offers the possibility to produce very soft, spherical granules which show an excellent flowability. The granules can be compressed to compacts of high homogeneity and they are completely redispersable. Freeze Granulation is a granulation technique which combines the advantages of spray drying and freeze drying. Hard granules and agglomerates are prevented by this technique excluding capillary forces during drying.

Lab-scale granulator LS-2 — Zeolite granulation by LS-2

Spray-freezing and freeze drying

Spray-freezing and freeze drying – Freeze Granulation

PowderPro AB develop, manufacture, market and sell equipment and know-how for Freeze Granulation, spray freezing and subsequent freeze drying (lyophilization or cryodesiccation). Freeze Granulation was developed in late 1980s at Swedish Ceramic Institute in Göteborg and it is also a development of Spray Freeze Drying (SFD) and Spray Freezing into Liquid (SFL).

Spray cooling or rather called spray freezing is the first step in the freeze granulation process where a suspension is atomized, sprayed with a nozzle, into a chamber with liquid nitrogen. The small droplets are then rapidly frozen with a minimum of ice crystal growth. The frozen material (granules) are then transferred to a freeze dryer where the ice is removed by sublimation, i e never go through a liquid state that ensure homogeneity preservation.

Below you can see an illustration of the Freeze Granulation process.