News on how Freeze Granulation can improve our powder properties

ECerS XIII Conference – Limoges, France

ECerS XIII Conference – Limoges, France – Welcome to PowderPro’s stand No 1 at the exhibition at ECerS XIII Conference (European Ceramic Society) in Limoges, France from the 23rd to the 27th of June 2013. We look forward to meet customers, partners and new contacts for interesting discussions in our stand!

We plan to have our equipment available at a nearby lab for you to see the process of Freeze Granulation.

Please contact us and we will further discuss the opportunities with Freeze Granulation in your powder system and read more on technology and a Granulation Test of your powder system.

Synthetic diamond powder granulation

Homogeneous diamond tools by Freeze Granulation

Synthetic diamond powder granulation by Freeze Granulation is today being used for to make homogeneous granules for diamond tools with long tool-life and optimal performance.

Please contact us and we will further discuss the opportunities with Freeze Granulation in your powder system and read more on technology and a Granulation Test of your powder system.

Synthetic diamond powder granulation

Thermally sensitive nanoparticles

Freeze Granulation of thermally sensitive nanoparticles

By using Freeze Granulation, spray freeze drying (SFD), you can produce dry-powder aggregates of thermally sensitive nanoparticles. Dry powder inhaler (DPI) delivery of therapeutic nanoparticles requires the nanoparticles to be transformed into inhalable micro-scale aggregate structures (i.e. nano-aggregates). With Freeze Granulation you will be able to optimize the aerosolization efficiency of the nano-aggregates, while keeping the morphology, production yield, flowability, and aqueous reconstitution in the desirable range.

Please contact us and we will further discuss the opportunities with Freeze Granulation in your powder system and read more on technology and a Granulation Test of your powder system.

Granule of thermally sensitive nanoparticles

Freeze Granulation of Nanomaterials on Slideshare

Please see our presentation Freeze Granulation of Nanomaterials on Slideshare.

How Freeze Granulation can improve the homogeneity of your nanomaterials and make it possible to redisperse a nanomaterial that have been dried.

Please contact us and we will further discuss the opportunities with Freeze Granulation in your powder system and read more on technology and a Granulation Test of your powder system.

Protein aerosol powders

Protein aerosol powders by Freeze Granulation

Freeze granulation, as opposed to spray drying, has been shown to produce protein particles with light and porous characteristics, which offered powders with superior aerosol performance due to favorable aerodynamic properties, suitable granulation technology for protein inhalation powders.

Please contact us and we will further discuss the opportunities with Freeze Granulation in your powder system and read more on technology and we propose a Granulation Test of your powder system.

Needle-free ballistic powder delivery

Needle-free ballistic powder delivery by applying Freeze Granulation you will be able to make microparticles with high insulin loading (nanosuspension) suitable for needle-free ballistic drug delivery. The resulting granules are homogeneous and robust with a diameter of around 50-150 µm, with a narrow size distribution and a high content of insulin.

Please contact us and we will further discuss the opportunities with Freeze Granulation on your powder system and read more on technology and we propose a Granulation Test of your powder system.

Zeolite granulation

Freeze Granulation of zeolite materials offers the possibility to produce very soft, spherical granules which show an excellent flowability. The granules can be compressed to compacts of high homogeneity and they are completely redispersable. Freeze Granulation is a granulation technique which combines the advantages of spray drying and freeze drying. Hard granules and agglomerates are prevented by this technique excluding capillary forces during drying.

Lab-scale granulator LS-2 — Zeolite granulation by LS-2

Spray-freezing and freeze drying

Spray-freezing and freeze drying – Freeze Granulation

PowderPro AB develop, manufacture, market and sell equipment and know-how for Freeze Granulation, spray freezing and subsequent freeze drying (lyophilization or cryodesiccation). Freeze Granulation was developed in late 1980s at Swedish Ceramic Institute in Göteborg and it is also a development of Spray Freeze Drying (SFD) and Spray Freezing into Liquid (SFL).

Spray cooling or rather called spray freezing is the first step in the freeze granulation process where a suspension is atomized, sprayed with a nozzle, into a chamber with liquid nitrogen. The small droplets are then rapidly frozen with a minimum of ice crystal growth. The frozen material (granules) are then transferred to a freeze dryer where the ice is removed by sublimation, i e never go through a liquid state that ensure homogeneity preservation.

Below you can see an illustration of the Freeze Granulation process.

Nano ice formation in granules

Nano ice in granules by Freeze Granulation

Nano ice formation in granules by Freeze Granulation process is a key factor for the unique homogeneity of particles and binders achieved in the resulting granules. This is especially important for nanopowders, fine particles and binders where migration of these could occur during conventional drying, like spray drying.

Granule with nano-ice and nanopowder — Nano-ice formation in granules of nanoparticles

LED photoluminescence granulation

LED photoluminescence granulation

Freeze Granulation is today used for commercial production of homogeneous granules for the production of oxides used as a ceramic phosphor plate for white illumination in LED Lighting. By using Freeze Granulation of the powder and binder mixture, compared with spray drying, it is possible to manufacture a homogeneous phosphor plate with optimal properties for to generate a soft and warm white light from high power LEDs.