Category: Scientific papers

Solid state of inhalable high dose powders Bishal Raj Adhikari, Keith C. Gordon, Shyamal C. Das Abstract High dose inhaled powders have received increased attention for treating lung infections. These powders can be prepared using techniques such as spray drying, spray-freeze drying, crystallization, and milling. The selected preparation technique is known to influence the solid… Continue reading Solid state of inhalable high dose powders

Effect of spray freeze drying on the structural modification and rehydration characteristics of micellar casein powders Jinbo Ren, Minjie Liao, Lingjun Ma, Fang Chen, Xiaojun Liao, Xiaosong Hu, Song Miao, John Fitzpatrick, Junfu Ji Abstract Micellar casein (MC) is usually spray-dried into powder form for transportation and storage. However, the micellar structure maintained by colloidal… Continue reading Effect of spray freeze drying on the structural modification and rehydration characteristics of micellar casein powders

Ointment containing spray freeze-dried metronidazole effective against rosacea Klára Szentmihályi, Krisztina Móricz, Gábor Gigler, Zoltán May, Eszter Bódis, Judit Tóth, Mónika Bakonyi, Szilvia Klébert, Tivadar Feczkó, Zoltán Károly Abstract Rosacea is a chronic, inflammatory skin disease that affects about 10% of the population. Metronidazole-containing ointments are typically recommended for the daily treatment of symptoms. For… Continue reading Ointment containing spray freeze-dried metronidazole effective against rosace

Microencapsulation of High-Content Actives Using Biodegradable Silk Materials Muchun Liu, Pierre-Eric Millard, Henning Urch, Ophelie Zeyons, Douglas Findley, Rupert Konradi, Benedetto Marelli Abstract There is a compelling need across several industries to substitute non-degradable, intentionally added microplastics with biodegradable alternatives. Nonetheless, stringent performance criteria in actives’ controlled release and manufacturing at scale of emerging materials… Continue reading Microencapsulation of High-Content Actives Using Biodegradable Silk Materials

Spray freeze drying of dairy products: Effect of formulation on dispersibility Alberto Baldelli, Hale Oguzlu, Diana Yumeng Liang, Alison Subiantoro, Meng Wai Woo, Anubhav Pratap-Singh Abstract Milk powders are commonly produced by using the technique of spray drying. In this work, we propose the use of spray freeze drying technology to improve the re-dispersibility of… Continue reading Spray freeze drying of dairy products: Effect of formulation on dispersibility

Spray Freezing Coating on the Carrier Particles for Powder Preparation Qing Xu, Ruixin Wang, Fan Zhang, Ruifang Wang, Long Wu, Bo Lin Abstract Carrier particle spray freeze-drying is a new technology with high added value for thermosensitive powder spray freeze-drying. The technology includes the following steps: atomization, coating, freezing, and drying. Due to the action… Continue reading Spray Freezing Coating on the Carrier Particles for Powder Preparation

Debate: Nanoparticles – a blessing or a curse? Hans Leuenberger Abstract This chapter was inspired by Ilya Prigogine (Nobel laureate 1977) and by six axioms derived1 earlier, such as A1, Far from equilibrium conditions, favoring transformations from disorder into order leading to the creation of life, and A5 and 6, The evolutionary process uses all… Continue reading Debate: Nanoparticles – a blessing or a curse?

Spray freeze drying for protein encapsulation: Impact of the formulation to morphology and stability Alberto Baldelli, Yigong Guo, Hui Xin Ong, Aylin Cidem, Anika Singh, Daniela Traini, Anubhav Pratap-Singh Abstract Proteins, the building blocks of life, are increasingly being used as therapeutics for treating several diseases. Yet, there are challenges in the delivery of highly… Continue reading Spray freeze drying for protein encapsulation: Impact of the formulation to morphology and stability

Modulating the Pore Architecture of Ice-Templated Dextran Microparticles Using Molecular Weight and Concentration Tero Kämäräinen, Kazunori Kadota, Jun Yee Tse, Hiromasa Uchiyama, Shinya Yamanaka, Yuichi Tozuka Abstract Spray freeze drying (SFD) is an ice templating method used to produce highly porous particles with complex pore architectures governed by ice nucleation and growth. SFD particles have… Continue reading Modulating the Pore Architecture of Ice-Templated Dextran Microparticles Using Molecular Weight and Concentration

Spray freeze-drying for inhalation application: process and formulation variables Mostafa Rostamnezhad, Hossein Jafari, Farzad Moradikhah, Sara Bahrainian, Homa Faghihi, Reza Khalvati, Reza Bafkary, Alireza Vatanara Abstract High porous particles with specific aerodynamic properties were processed by the spray freeze-drying (SFD) method. Comprehensive knowledge about all aspects of the SFD method is required for particle engineering… Continue reading Spray freeze-drying for inhalation application: process and formulation variables