Category: Scientific papers

Combination of α-lactalbumin and gum arabic for microencapsulation of L-menthol: The effects on flavor release during storage and rehydration Siyi Peng, Jiajia Zhao, Yaru Wang, Fang Chen, Xiaosong Hu, Lingjun Ma, Junfu Ji Abstract L-menthol-containing food products generally show the flavor loss during storage due to their high volatility. The hydrophobicity of L-menthol also causes… Continue reading Combination of α-lactalbumin and gum arabic for microencapsulation of L-menthol: The effects on flavor release during storage and rehydration

Inhalable aerosol microparticles with low carrier dosage and high fine particle fraction prepared by spray-freeze-drying Quan Xi, Jiaying Miao, Zhen Cao, Hao Wang Abstract Co-suspension drug-loading technology, namely Aerosphere™, can improve fine particle fraction (FPF) and delivered dose content uniformity (DDCU). However, because of its poor drug-loading efficacy, the phospholipid carrier dosage in Aerosphere™ is… Continue reading Inhalable aerosol microparticles with low carrier dosage and high fine particle fraction prepared by spray-freeze-drying

Aquivion® PFSA-based spray-freeze dried composite materials with SiO2 and TiO2 as hybrid catalysts for the gas phase dehydration of ethanol to ethylene in mild conditions Stefania Albonetti, Martina Battisti, Sara Andreaoli, Riccardo Bacile, Claudio Oldani, Simona Ortelli, Anna Luisa Costa, Giuseppe Fornasari Abstract The spray-freeze-drying approach was successfully applied for the preparation of Aquivion based… Continue reading Aquivion® PFSA-based spray-freeze dried composite materials with SiO2 and TiO2 as hybrid catalysts for the gas phase dehydration of ethanol to ethylene in mild conditions

Effect of different drying methods on the functional properties of probiotics encapsulated using prebiotic substances K. S. Yoha, J. A. Moses, C. Anandharamakrishnan Abstract Probiotics and prebiotics together work synergistically as synbiotics and confer various health benefits. Many studies on synbiotic foods only focus on the survival of probiotics but fail to evaluate their functional… Continue reading Effect of different drying methods on the functional properties of probiotics encapsulated using prebiotic substances

Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals Fakhrossadat Emami, Mahsa Keihan Shokooh, Seyed Jamaleddin Mostafavi Yazdi Abstract Background: Most biopharmaceuticals are developed in liquid dosage forms that are less stable than solid forms. To ensure the stability of biopharmaceuticals, it is critical to use an effective drying technique in the… Continue reading Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals

Spray freeze dried niclosamide nanocrystals embedded dry powder for high dose pulmonary delivery Shengyu Zhang, Shen Yan, Kangwei Lu, Shixuan Qiu, Xiao Dong Chen, Winston Duo Wu Abstract Based on the drug repositioning strategy, niclosamide (NCL) has shown potential applications for treating COVID-19. However, the development of new formulations for effective NCL delivery is still challenging. Herein, NCL-embedded dry powder… Continue reading Spray freeze dried niclosamide nanocrystals embedded dry powder for high dose pulmonary delivery

Crystal Size Dependence of the Photo-Electrochemical Water Oxidation on Nanoparticulate CaTiO3 Monika Klusáčková, Roman Nebel, Kateřina Minhová Macounová, Petr Krtil Abstract Nanocrystalline CaTiO3 materials with controlled particle size were prepared using spray-freezing/freeze-drying approach utilizing gelatine as a structure-directing agent. The resulting materials show characteristic particle size between 19 and 60 nm. The shape of the nanocrystals… Continue reading Crystal Size Dependence of the Photo-Electrochemical Water Oxidation on Nanoparticulate CaTiO3

Spray Freeze Drying of Biologics: A Review and Applications for Inhalation Delivery Susana Farinha, João V. Sá, Paulo Roque Lino, Marco Galésio, João Pires, Miguel Ângelo Rodrigues, João Henriques Abstract Biopharmaceuticals have established an indisputable presence in the pharmaceutical pipeline, enabling highly specific new therapies. However, manufacturing, isolating, and delivering these highly complex molecules to… Continue reading Spray Freeze Drying of Biologics: A Review and Applications for Inhalation Delivery

Strategies for stabilization and preservation of liposomes Pintu Chowdhary, L. Mahalakshmi, Sayantani Dutta, J.A. Moses, C. Anandharamakrishnan Abstract The stabilization of liposomes is an important aspect for maintaining the integrity of liposome structure. The stability of liposomes reduces in terms of uncontrollable fusion, undesirable payload loss, short shelf life, and unexpected mixing. Additionally, liposomes undergo… Continue reading Strategies for stabilization and preservation of liposomes

Development and performance evaluation of amorphous microencapsules containing lutein nanoparticles via antisolvent precipitation followed by spray/freeze-drying Gang Zhang, Shihong Hu, Xiao Wang, Yanna Zhao, Min Liu, Jun Han, Sangeeta Prakash, Zhengping Wang, Zhuang Ding Summary This study developed nano-sized lutein-loaded solid microcapsules using antisolvent precipitation followed by spray/freeze-drying methods to improve chemical stability and dissolution… Continue reading Development and performance evaluation of amorphous microencapsules containing lutein nanoparticles via antisolvent precipitation followed by spray/freeze-drying