ASEPTIC SPRAY FREEZE DRYING AS A TOOL FOR SUPPLY CHAIN FLEXIBILISATION F. Kongoli, S. Buchmann, G. Imanidis, I. Karim, G. Kimura, G. Knipp, M. Makanga, N. Menshutina, P. Swaan, M. Tanner, H. Tarabishi Abstract Spray Freeze Drying (SFD) is an innovative lyophilization technology that is now entering industrial applications in lab, pilot and manufacturing scale… Continue reading ASEPTIC SPRAY FREEZE DRYING AS A TOOL FOR SUPPLY CHAIN FLEXIBILISATION
Category: Scientific papers
Lowering compaction pressure and sintering temperature of alumina using spray freeze granulation dried granules
Lowering compaction pressure and sintering temperature of alumina using spray freeze granulation dried granules Naoki Kondo1, Akihiro Shimamura, Mikinori Hotta, Junichi Tatami and Shinya Kawaguchi Abstract Spray drying (SD) and spray freeze granulation drying (SFGD) are the granulation processes of ceramic powder. Alumina green body made from SFGD granules via compaction has a relatively uniform… Continue reading Lowering compaction pressure and sintering temperature of alumina using spray freeze granulation dried granules
Effect of spray freeze drying on the structural modification and rehydration characteristics of micellar casein powders
Effect of spray freeze drying on the structural modification and rehydration characteristics of micellar casein powders Jinbo Ren, Minjie Liao, Lingjun Ma, Fang Chen, Xiaojun Liao, Xiaosong Hu, Song Miao, John Fitzpatrick, Junfu Ji Abstract Micellar casein (MC) is usually spray-dried into powder form for transportation and storage. However, the micellar structure maintained by colloidal calcium phosphate (CCP) and hydrophobic forces leads to poor rehydration ability of MC powders, which limits its… Continue reading Effect of spray freeze drying on the structural modification and rehydration characteristics of micellar casein powders
Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying
Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying Koki Ogawa, Otowa Aikawa, Tatsuaki Tagami, Takaaki Ito, Kohei Tahara, Shigeru Kawakami, Tetsuya Ozeki Abstract A powder formulation for mucosal administration of mRNA-encapsulated lipid nanoparticles (mRNA-LNPs) is expected to be useful for respiratory diseases. Although freeze-drying is widely used to obtain solid formulations of mRNA-LNPs, highly hydrosoluble cryoprotectants, such as sucrose are necessary. However, sucrose is not a suitable excipient for… Continue reading Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying
Freezing behaviour and spray freeze granulation drying of silicon nitride slurries prepared from tert-butyl alcohol and cyclohexane solvent mixtures
Freezing behaviour and spray freeze granulation drying of silicon nitride slurries prepared from tert-butyl alcohol and cyclohexane solvent mixtures Riko Yamazaki, Junichi Tatami, Motoyuki Iijima, Shinya Kawaguchi, Naoki Kondo Abstract A spray freeze granulation drying technique is suitable for obtaining soft and homogeneous granules, but the use of an aqueous slurry could degrade raw materials such as nitride. In this study, the freezing behaviour… Continue reading Freezing behaviour and spray freeze granulation drying of silicon nitride slurries prepared from tert-butyl alcohol and cyclohexane solvent mixtures
Spray freeze-drying for inhalable L-leucine, mannitol-based microparticles: The impact of process variables, L-leucine, and crystallinity on Aerosolization properties
Spray freeze-drying for inhalable L-leucine, mannitol-based microparticles: The impact of process variables, L-leucine, and crystallinity on Aerosolization properties Lorena Pasero, Adamo Sulpizi, Tomaso Guidi, Roberto Pisano Abstract In this study, microparticles carrying salbutamol sulphate were produced by pneumatic spray freeze-drying. The optimal particle size was assessed through a model, associated with a design of experiments. Growing solid concentrations and flow rate led to decreasing geometric diameters, while… Continue reading Spray freeze-drying for inhalable L-leucine, mannitol-based microparticles: The impact of process variables, L-leucine, and crystallinity on Aerosolization properties
Effect of freeze drying and spray drying on physical properties, morphology and in vitro release kinetics of vitamin D3 nanoparticles
Effect of freeze drying and spray drying on physical properties, morphology and in vitro release kinetics of vitamin D3 nanoparticles Iqra Bashir, Sajad Mohd Wani, Auqib Ahmad Bhat, Akhtar Ali Khan, Syed Zameer Hussain, Shaiq Ahmad Ganai, Nadira Anjum Abstract Encapsulation is a viable and effective technique for protection and stability of vitamin D3 during processing. In the present experiment, the effect of ultrasonication on encapsulation of vitamin D3 using… Continue reading Effect of freeze drying and spray drying on physical properties, morphology and in vitro release kinetics of vitamin D3 nanoparticles
Spray freeze drying – A synergistic drying technology and its applications in the food industry to preserve bioactive compounds
Spray freeze drying – A synergistic drying technology and its applications in the food industry to preserve bioactive compounds Nisha Chhabra, Mehak Arora, Diksha Garg, Mahesh Kumar Samota Abstract In the food industry, drying is a crucial unit process for extending product shelf life. Many methods are available for drying of foods but spray drying and freeze drying have been widely adopted… Continue reading Spray freeze drying – A synergistic drying technology and its applications in the food industry to preserve bioactive compounds
Spray freeze drying as a novel drying process for the formulation of probiotic powders containing Lacticaseibacillus rhamnosus GG
Spray freeze drying as a novel drying process for the formulation of probiotic powders containing Lacticaseibacillus rhamnosus GG A. Steegmans, M. Plitzko, B. Luy, S. Lebeer, F. Kiekens Abstract Spray freeze drying was evaluated as a drying process for the formulation and stabilization of probiotic powders This technology combines spray freezing into cold vapour followed by rotational bulk freeze drying, and was investigated to combine the… Continue reading Spray freeze drying as a novel drying process for the formulation of probiotic powders containing Lacticaseibacillus rhamnosus GG
Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying
Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying Koki Ogawa, Otowa Aikawa, Tatsuaki Tagami, Takaaki Ito, Kohei Tahara, Shigeru Kawakami, Tetsuya Ozeki Abstract A powder formulation for mucosal administration of mRNA-encapsulated lipid nanoparticles (mRNA-LNPs) is expected to be useful for respiratory diseases. Although freeze-drying is widely used to obtain solid formulations of mRNA-LNPs, highly hydrosoluble cryoprotectants, such as sucrose are necessary. However, sucrose is not… Continue reading Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying