Category: Scientific papers

Novel Budesonide Particles for Dry Powder Inhalation Prepared Using a Microfluidic Reactor Coupled With Ultrasonic Spray Freeze Drying Saboti D, Maver U, Chan HK, Planinšek O Abstract Budesonide (BDS) is a potent active pharmaceutical ingredient, often administered using respiratory devices such as metered dose inhalers, nebulizers, and dry powder inhalers. Inhalable drug particles are conventionally… Continue reading Novel Budesonide Particles for Dry Powder Inhalation Prepared Using a Microfluidic Reactor Coupled With Ultrasonic Spray Freeze Drying.

Effect of the solvent composition and annealing process on the preparation of spray freeze-dried acetaminophen powder Jae-Young Her, Kwang-Geun Lee Abstract The analgesic and physical properties of acetaminophen powder suitable as an inhaled drug produced by spray freeze-drying (SFD) were compared with those of raw acetaminophen. A laser particle size analyzer and scanning electron microscopy… Continue reading Effect of the solvent composition and annealing process on the preparation of spray freeze-dried acetaminophen powder

Spray freeze granulation of submicrometre α-alumina using ultrasonicati S. Ghanizadeh, P. Ramanujam, B. Vaidhyanathan, J. Binner Abstract Granulation is a key factor towards improvement of the flowability of fine ceramic powders to make them suitable for industrial dry pressing. Controlled granulation of fine alumina particles with a primary particle size of ∼ 150 nm was… Continue reading Spray freeze granulation of submicrometre α-alumina using ultrasonicati

Effect of freeze-drying treatment on the optical properties of SPS-sintered alumina M. Suárez, A. Fernández, J.L. Menéndez, M. Nygren, R. Torrecillas, Z. Zhao Abstract This study looks at the influence of alumina powder processing on the preparation of transparent alumina by Spark Plasma Sintering (SPS). Zeta potential measurements were carried out on alumina suspensions in… Continue reading Effect of freeze-drying treatment on the optical properties of SPS-sintered alumina

Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars W.F. Tonnis, J.-P. Amorij, M.A. Vreeman, H.W. Frijlink, G.F. Kersten, W.L.J. Hinrichs Abstract The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2–8 °C). This dependence on a cold-chain is highly challenging in areas… Continue reading Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars

Encapsulation of antigen-loaded silica nanoparticles into microparticles for intradermal powder injection Yibin Deng, Roman Mathaes, Gerhard Winter, Julia Engert Abstract Epidermal powder immunisation (EPI) is being investigated as a promising needle-free delivery methods for vaccination. The objective of this work was to prepare a nanoparticles-in-microparticles (nano-in-micro) system, integrating the advantages of nanoparticles and microparticles into… Continue reading Encapsulation of antigen-loaded silica nanoparticles into microparticles for intradermal powder injection

Fostering the properties of Zr0.8Sn0.2TiO4 (ZST) ceramics via freeze granulation without sintering additives S. M. Olhero, Ajay Kaushal and J. M. F. Ferreira Abstract The present paper reports the overall benefits of freeze granulation for enhancing the properties of zirconium tin titanate Zr0.8Sn0.2TiO4 (ZST) ceramics in the total absence of sintering additives. The ZST powder… Continue reading Fostering the properties of Zr0.8Sn0.2TiO4 (ZST) ceramics via freeze granulation without sintering additives

Spray-Freeze-Drying approach for soluble coffee processing and its effect on quality characteristics S. Padma Ishwarya, C. Anandharamakrishnan Abstract The suitability of Spray-Freeze-Drying (SFD) technique for soluble coffee processing was evaluated. The resultant product characteristics were compared against its spray-dried (SD) and freeze-dried (FD) counterparts. SFD and FD coffee powders exhibited a comparable aroma profile as… Continue reading Spray-Freeze-Drying approach for soluble coffee processing and its effect on quality characteristics

A study to develop nano-spray freeze dried Co/Ce–La catalyst for the production of hydrogen from bio-renewable feedstock Dalia R. Abd El-Hafiz, Mohamed A. Ebiad Abstract Ultra-fine Ce–Co and Cox/Ce–La (x = 4 and 10%) solid solutions (SS) were prepared for the first time by spray freezing technology, and evaluated in bio-ethanol steam reforming reaction for… Continue reading A study to develop nano-spray freeze dried Co/Ce–La catalyst for the production of hydrogen from bio-renewable feedstock

Jet-vortex spray freeze drying for the production of inhalable lyophilisate powders Wanning S, Süverkrüp R, Lamprecht A Abstract Spray-freeze-dried powders were suggested for nasal, epidermal (needle-free injection) or pulmonary application of proteins, peptides or nucleic acids. In spray-freeze-drying processes an aqueous solution is atomized into a refrigerant medium and subsequently dried by sublimation. Droplet-stream generators… Continue reading Jet-vortex spray freeze drying for the production of inhalable lyophilisate powders