Category: Scientific papers

Advax augments B and T cell responses upon influenza vaccination via the respiratory tract and enables complete protection of mice against lethal influenza virus challenge Tomar J, Patil HP, Bracho G, Tonnis WF, Frijlink HW, Petrovsky N, Vanbever R, Huckriede A, Hinrichs WLJ Abstract Administration of influenza vaccines via the respiratory tract has potential benefits… Continue reading Advax augments B and T cell responses upon influenza vaccination via the respiratory tract and enables complete protection of mice against lethal influenza virus challenge

Using two-fluid nozzle for spray freeze drying to produce porous powder formulation of naked siRNA for inhalation Liang W, Chow MYT, Chow SF, Chan HK, Kwok PCL, Lam JKW Abstract Spray freeze drying is an attractive technology to produce powder formulation for inhalation. It can be used to generate large porous particles which tend to… Continue reading Using two-fluid nozzle for spray freeze drying to produce porous powder formulation of naked siRNA for inhalation.

Processing of sintered and CVD coated SiC/CNFs thin composite tubes Mubina Shaik, Asit Kumar Khanra, Bhaskar Prasad Saha Abstract Silicon carbide (SiC) and its composite powders dispersed with 1–3 wt% carbon nano-fibres (CNFs) were spray freeze granulated to produce spherical granules with uniform composition. Powders were shaped to thin dense tubes for use in a harsh… Continue reading Processing of sintered and CVD coated SiC/CNFs thin composite tubes

Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals Fakhrossadat Emami, Alireza Vatanara, Eun Ji Park, Dong Hee Na Abstract Solid dosage forms of biopharmaceuticals such as therapeutic proteins could provide enhanced bioavailability, improved storage stability, as well as expanded alternatives to parenteral administration. Although numerous drying methods have been used for preparing dried protein… Continue reading Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals

Influence of process variables on physical characteristics of spray freeze dried cellulose nanocrystals Wissam Abdallah, Musa R. Kamal Abstract This study compares the characteristics of cellulose nanocrystal (CNC) agglomerates prepared using spray drying, freeze drying, and spray freeze drying. Moreover, the effect of the concentration of CNC in the initial aqueous dispersion (~ 0.5–10.0 wt%) on… Continue reading Influence of process variables on physical characteristics of spray freeze dried cellulose nanocrystals

Ultrasonic spray-freeze drying of partially purified microbial transglutaminase Hilal Isleroglu, Izzet Turker, Mehmet Tokatli, Banu Koc Abstract Ultrasonic spray-freeze drying (USFD) was evaluated to produce partially purified microbial transglutaminase (mTGase) powder, and the effects of the process conditions (a nozzle frequency of 48–120 kHz and a flow rate of 2–8 ml/min) on enzyme activity and… Continue reading Ultrasonic spray-freeze drying of partially purified microbial transglutaminase

Encapsulation of cationic iridium(III) tetrazole complexes into a silica matrix: synthesis, characterization and optical properties Ilaria Zanoni, Valentina Fiorini, Marcos Rosado, Belén Ballesteros, Maria Androulidaki, Magda Blosi, Simona Ortelli, Stefano Stagni, Michele Dondia and Anna Luisa Costa Abstract Herein we report the easy incorporation of brightly phosphorescent cationic iridium(III) tetrazole complexes into a silica based… Continue reading Encapsulation of cationic iridium(III) tetrazole complexes into a silica matrix: synthesis, characterization and optical properties

Spray freeze-dried monolithic silica aerogel based on water-glass with thermal superinsulating properties Yuelei Pan, Xudong Cheng, Ting zhou, Lunlun Gong, Heping Zhang Abstract In this study, silica aerogels were prepared using water-glass precursor based on two drying strategies, namely conventional freeze drying (C-FD) and spray freeze drying (S-FD). It was known that the pore structure… Continue reading Spray freeze-dried monolithic silica aerogel based on water-glass with thermal superinsulating properties

Porous Microparticles Containing Raloxifene Hydrochloride Tailored by Spray Freeze Drying for Solubility Enhancement Seyyed Pouya Hadipour Moghaddam, Sajjad Farhat, Alireza Vatanara Abstract Purpose: The goal of this study was to improve the solubility and dissolution behavior of Raloxifene Hydrochloride (RH) using Spray Freeze Drying (SFD) technique. Methods: For achieving this goal, series of samples containing… Continue reading Porous Microparticles Containing Raloxifene Hydrochloride Tailored by Spray Freeze Drying for Solubility Enhancement

Spray-Freeze Drying: a Suitable Method for Aerosol Delivery of Antibodies in the Presence of Trehalose and Cyclodextrins Pouya MA, Daneshmand B, Aghababaie S, Faghihi H, Vatanara A Abstract We aimed to prepare spray-freeze-dried powder of IgG considering physicochemical stability and aerodynamic aspects. Spray-freeze drying (SFD) exposes proteins to various stresses which should be compensated by… Continue reading Spray-Freeze Drying: a Suitable Method for Aerosol Delivery of Antibodies in the Presence of Trehalose and Cyclodextrins.