Category: Scientific papers

Fabrication of uniform enzyme-immobilized carbohydrate microparticles with high enzymatic activity and stability via spray drying and spray freeze drying Shengyu Zhang, Hong Lei, Xingmin Gao, Xingxing Xiong, Winston Duo Wu, Zhangxiong Wu, Xiao Dong Chen Abstract Enzyme-immobilized particles with high enzymatic activities are fundamentally and practically important for many areas, such as pharmaceuticals, medicine, and… Continue reading Fabrication of uniform enzyme-immobilized carbohydrate microparticles with high enzymatic activity and stability via spray drying and spray freeze drying

Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery Wanling Liang, Alan Y.L. Chan, Michael Y.T. Chow, Fiona F.K.Lo, Yingshan Qiu, Philip C.L. Kwok, Jenny K.W. Lam Abstract The therapeutic potential of small nucleic acids such as small interfering RNA (siRNA) to treat lung diseases has been successfully demonstrated in many… Continue reading Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery

System-level analysis of a novel air-cooled condenser using spray freezing of phase change materials Ben Xu, Swanand Bhagwat, Hongxin Xu, Arif Rokoni, Matthew McCarthy, Ying Sun Abstract A comprehensive system-level analysis is performed for a novel air-cooled condenser based on spray freezing of phase change materials (PCMs). This novel air-cooled condenser uses PCMs to decouple… Continue reading System-level analysis of a novel air-cooled condenser using spray freezing of phase change materials

Spray-freeze-drying in the manufacture of pharmaceuticals Abstract Over the last decade, the development of new drug delivery methods and devices for dry powder inhalation1, needle-free intradermal powder injection2 or sustained parenteral drug delivery3 has led to an increasing demand for powder formulations incorporating an active pharmaceutical ingredient (API)4,5. In contrast to the production and handling… Continue reading Spray-freeze-drying in the manufacture of pharmaceuticals

Protein Spray-Freeze Drying. Effect of Atomization Conditions on Particle Size and Stability Henry R CostantinoLaleh FirouzabadianKen HogelandChichih WuChris BeganskiKaren G CarrasquilloMelissa CórdovaKai GriebenowStephen E ZaleMark A Tracy Abstract Purpose. To investigate the effect of atomization conditions on particle size and stability of spray-freeze dried protein. Methods. Atomization variables were explored for excipient-free (no zinc added)… Continue reading Protein Spray-Freeze Drying. Effect of Atomization Conditions on Particle Size and Stability

Spray-freeze-drying of nanosuspensions: the manufacture of insulin particles for needle-free ballistic powder delivery Heiko Schiffter, Jamie Condliffe, Sebastian Vonhoff Abstract The feasibility of preparing microparticles with high insulin loading suitable for needle-free ballistic drug delivery by spray-freeze-drying (SFD) was examined in this study. The aim was to manufacture dense, robust particles with a diameter of… Continue reading Spray-freeze-drying of nanosuspensions: the manufacture of insulin particles for needle-free ballistic powder delivery

A spray-freezing approach to reduced graphene oxide/MoS2 hybrids for superior energy storage Tao Cheng, Jin Xu, Ziqi Tan, Jianglin Ye, Zhuchen Tao, Zhenzhen Du, Ying Wu, Shuilin Wu, Hengxing Ji, Yan Yu. Yanwu Zhu Abstract A three-dimensional (3D) architectural hybrid, composed of reduced graphene oxide (RGO) and ultrathin MoS2 layers, is fabricated by a facile… Continue reading A spray-freezing approach to reduced graphene oxide/MoS2 hybrids for superior energy storage

Development of Inhalable Dry Powder Formulations Loaded with Nanoparticles Maintaining Their Original Physical Properties and Functions Okuda T Abstract Functional nanoparticles, such as liposomes and polymeric micelles, are attractive drug delivery systems for solubilization, stabilization, sustained release, prolonged tissue retention, and tissue targeting of various encapsulated drugs. For their clinical application in therapy for pulmonary… Continue reading Development of Inhalable Dry Powder Formulations Loaded with Nanoparticles Maintaining Their Original Physical Properties and Functions

Shrinkage of spray-freeze-dried microparticles of pure protein for ballistic injection by manipulation of freeze-drying cycle Straller G, Lee G Abstract Spray-freeze-drying was used to produce shrivelled, partially-collapsed microparticles of pure proteins that may be suitable for use in a ballistic injector. Various modifications of the freeze drying cycle were examined for their effects on collapse… Continue reading Shrinkage of spray-freeze-dried microparticles of pure protein for ballistic injection by manipulation of freeze-drying cycle

Mechanical particle coating using polymethacrylate nanoparticle agglomerates for the preparation of controlled release fine particles: The relationship between coating performance and the characteristics of various polymethacrylates. Kondo K, Kato S, Niwa T Abstract We aimed to understand the factors controlling mechanical particle coating using polymethacrylate. The relationship between coating performance and the characteristics of polymethacrylate… Continue reading Mechanical particle coating using polymethacrylate nanoparticle agglomerates for the preparation of controlled release fine particles: The relationship between coating performance and the characteristics of various polymethacrylates.