Category: Scientific papers

From Liquid Feeds to Functional Powders: Process Engineering, Quality, Valorisation and Emerging Innovations in Spray Drying of Fruits and Vegetables E. K. Anshida Beegum, S. Shameena, P. R. Geetha Lekshmi, Athulya S. Kumar, S. S. Sumi Abstract Spray drying is an effective and scalable technique for transforming highly perishable fruit and vegetable juices, extracts and… Continue reading From Liquid Feeds to Functional Powders: Process Engineering, Quality, Valorisation and Emerging Innovations in Spray Drying of Fruits and Vegetables

Drygels – A promising porous solid state carriers as a Novel Pharmaceutical Dosage Form S. R, Dhanusiya V, Yogashruthi S Abstract Traditional gel-based dosage forms, such as hydrogels and organogels, have been utilized extensively in topical and semi-solid pharmaceutical formulations. Nevertheless, constraints include inadequate compatibility with hydrophobic active pharmaceutical ingredients (APIs), vulnerability to microbial contamination,… Continue reading Drygels – A promising porous solid state carriers as a Novel Pharmaceutical Dosage Form

Metamorphosis in Drying Techniques for Biopharmaceuticals. Aditya Vikas Mane, Karina Arora, Nitya Srivastava, Prince Kumar, Gurvinder Singh, A. Yadav, Rajesh Kumar Abstract Biopharmaceutical products such as proteins, peptides, and nucleic acid-based therapeutics exhibit limited physicochemical stability in aqueous formulations. The process of developing and producing these bioproducts is often difficult and requires careful attention, particularly… Continue reading Metamorphosis in Drying Techniques for Biopharmaceuticals.

Nano spray-dried powders for efficient pulmonary delivery of proteins: an emphasis on comparisons of derived metrics determined by chapters <601> and <1604> Hao-Ying Li, Jing Guo Abstract Pulmonary protein delivery has proven to be an effective approach for the treatment of local and systemic diseases, and particles that can be efficiently inhaled into peripheral regions… Continue reading Nano spray-dried powders for efficient pulmonary delivery of proteins: an emphasis on comparisons of derived metrics determined by chapters <601> and <1604>

Formation of nanofibrous alumina by polyvinyl alcohol assisted sprayfreeze-drying technique Abdur Razzaque, Satoshi Irie, Koji Nakane Abstract In the experiment, three-dimensional net-structured alumina nanofibers were successfully prepared by spray-freeze-dryingprocess for the first time with an average diameter below 100 nm. Alumina nanofibers were obtained from polyvinyl alcohol(PVA) and boehmite precursor nanofibers after calcination at 500… Continue reading Formation of nanofibrous alumina by polyvinyl alcohol assisted sprayfreeze-drying technique

Lyophilised and Thermostable mRNA-Lipid Nanoparticle Vaccines: Excipient Selection, Process Design and Cold–Chain-Independent Distribution for Low- and Middle-Income Countries Anish Verma, Sarbjot Singh, Anita Devi Abstract The messenger RNA lipid nanoparticle (mRNA-LNP) platform reached the clinic at extraordinary speed, yet it carried an inconvenient inheritance: a liquid drug product that survives only at deep sub-zero temperatures.… Continue reading Lyophilised and Thermostable mRNA-Lipid Nanoparticle Vaccines: Excipient Selection, Process Design and Cold-Chain-Independent Distribution for Low- and Middle-Income Countries

From Pharmacological Uncertainty to Inhalation Development: An Evidence-Gated Roadmap for Codonopsis-Derived Triterpenoid Saponins Xiaohua Zhang, Chunxia Yang, Ping Wang, Ping Yang, Shanru Liu, Shubin Liu & Xiaoling Yang Abstract Codonopsis-derived triterpenoid saponins merit investigation because preclinical studies identify immunomodulatory activity and a biologically active parent-metabolite relationship. Pulmonary delivery could increase exposure at a lung target… Continue reading From Pharmacological Uncertainty to Inhalation Development: An Evidence-Gated Roadmap for Codonopsis-Derived Triterpenoid Saponins

Selecting an appropriate binder to prepare alumina granules via spray freeze granulation drying Naoki Kondo, Akihiro Shimamura, Mikinori Hotta, Junichi Tatami, Shinya Kawaguchi Abstract Spray freeze granulation drying (SFGD) is a granulation technique, involving the freezing of sprayed droplets, followed by freeze drying. This technique affords soft granules, which is advantageous for producing sintered bodies… Continue reading Selecting an appropriate binder to prepare alumina granules via spray freeze granulation drying

Application of Natural Polymers to Enhance Probiotic Stability Following the Spray Freeze Drying Method. M. Akrami, Mohammad Mahdi Omranpoor, Milad Imeni, Azadeh Emami, Vahid Ramezani Abstract Probiotics, defined as live microorganisms that confer health benefits on the host, are sensitive to environmental stresses. However, the stability of Lactobacillus casei during spray freeze drying (SFD) under… Continue reading Application of Natural Polymers to Enhance Probiotic Stability Following the Spray Freeze Drying Method.

Tailored Sugar-Mediated Porous Particle Structures for Improved Dispersion of Drug Nanoparticles in Spray-Freeze-Drying. Kumi Semba, Kazunori Kadota, Tero Kämäräinen, Yuzuki Nakayama, Yuta Hatanaka, Hiromasa Uchiyama, H. Arima-Osonoi, Kazumasa Sugiyama, Y. Tozuka Abstract We fabricated porous particles incorporating sugars (mannitol, sucrose, or dextran) and fenofibrate nanoparticles (FNPs) by using spray-freeze-drying (SFD). The type of sugar significantly… Continue reading Tailored Sugar-Mediated Porous Particle Structures for Improved Dispersion of Drug Nanoparticles in Spray-Freeze-Drying.