Category: Scientific papers

Designing highly porous amorphous celecoxib particles by spray freeze drying leads to accelerated drug absorption in-vivo D. Lucas, Jan Kožák, Annika Rautenberg, C. Chrétien, Y. Pellequer, A. Lamprecht Abstract Poorly water-soluble drugs are still a major challenge to overcome in order to achieve sufficiently high oral bioavailability. Spray freeze drying (SFD) is proposed here as… Continue reading Designing highly porous amorphous celecoxib particles by spray freeze drying leads to accelerated drug absorption in-vivo

Preparation of UO2 – PuO2 MOX fuel by freeze granulation or slip casting F. L. Lumia, L. Ramond, C. Pagnoux, G. Bernard-Granger Abstract The current production of MOX fuels is carried out by a dry process, involving steps with fine powders (grinding, mixing, pressing). In order to limit dust dissemination in glove boxes and have… Continue reading Preparation of UO2 – PuO2 MOX fuel by freeze granulation or slip casting

Controlling Mannitol Polymorphism for Enhanced Dispersibility in Spray Freeze-Dried Inhalable Microparticles Lorena Pasero, Andrea Silenzi, Adamo Sulpizi, Tomaso Guidi and Roberto Pisano Abstract Spray freeze-drying (SFD) is a novel technique for formulating dry powders, particularly for pulmonary drug delivery via dry powder inhalers (DPIs). Despite their low density and excellent aerodynamic properties, such powders are… Continue reading Controlling Mannitol Polymorphism for Enhanced Dispersibility in Spray Freeze-Dried Inhalable Microparticles

Systematic investigation of thermal process parameters on the morphology of spray-freeze-dried powders Annika Rautenberg, José Ignacio Vázquez-Olvera, Paul Bühlbecker, Alf Lamprecht Abstract Hypothesis: During spray freeze drying (SFD), vitrification, recrystallization, and polymorphic transitions govern particle morphology and mechanical integrity. We hypothesize that with control over freezing temperature, annealing relative to the glass transition of the maximally freeze-concentrated matrix… Continue reading Systematic investigation of thermal process parameters on the morphology of spray-freeze-dried powders

Correlation analysis of granulation condition, granule properties and green density of alumina ceramics fabricated by spray freeze granulation drying Ying Chung, Naoki Kondo, Ken’ichiro Kita, Mikinori Hotta, Junichi Tatami, Shinya Kawaguchi Abstract A scalable nitrogen‑free granulator that enables freezing temperature to be tuned as a process variable for powder granulation was used to fabricate alumina granules, and the obtained granules were further fabricated into green bodies… Continue reading Correlation analysis of granulation condition, granule properties and green density of alumina ceramics fabricated by spray freeze granulation drying

Preparation and characterization of alumina granules via tumbling and agitation granulation Naoki Kondo, Akihiro Shimamura, Mikinori Hotta Abstract Granulation of alumina powder was performed, and the characteristics of the resulting granules and the sintered bodies produced from them were evaluated. The granulation processes were conducted under the following conditions: hand sieving (HS), sieving using a… Continue reading Preparation and characterization of alumina granules via tumbling and agitation granulation

Performance evaluation of new polymer additives for technical ceramic shaping processes Ismail M’Barki, Fabrice Rossignol, Anne Aimable, Graham Abramo, Burcu Çelikkol Abstract This work evaluates acrylic additives as functional agents in alumina-based ceramic formulations to identify the conditions under which they can act as dispersants, binders and/or plasticizers. The methodology links formulation, shaping, drying, debinding,… Continue reading Performance evaluation of new polymer additives for technical ceramic shaping processes

Innovations in Orally Disintegrating Tablets Technology: FormulationPrinciples, Taste Masking Mechanisms, and BiopharmaceuticalConsiderations R Nepolean, K Chandramohan, S Sangeeth Kumar, D Anbarasu andS Sivasankari Abstract Orally disintegrating tablets (ODTs) have become a key patient centric oral dosage form that isdesigned to dissolve quickly in the mouth without the need of water, which aids in improving oraladherence… Continue reading Innovations in Orally Disintegrating Tablets Technology: FormulationPrinciples, Taste Masking Mechanisms, and BiopharmaceuticalConsiderations

Characterization of dispersion behavior of granular particles using laser diffraction and principal component analysis Daisuke Sasakura & Sho Kimura Abstract The dispersion of granulated particles in a liquid is an important process that significantly affects the quality, stability, and functionality of industrial products. It is also a phenomenon of interest in fundamental science. Changes in… Continue reading Characterization of dispersion behavior of granular particles using laser diffraction and principal component analysis

Encapsulation of food bioactive compounds using electrohydrodynamic techniques: from fundamentals to industrial applications Soubhagya Tripathy, Prem Prakash Srivastav Abstract The encapsulation of food bioactive compounds has gained significant attention as a strategy to improve their stability, bioavailability, and controlled release for functional food applications. Among emerging technologies, electrohydrodynamic (EHD) techniques—primarily electrospinning and electrospraying, offer unique… Continue reading Encapsulation of food bioactive compounds using electrohydrodynamic techniques: from fundamentals to industrial applications