Category: Scientific papers

Spray freeze dried niclosamide nanocrystals embedded dry powder for high dose pulmonary delivery Shengyu Zhang, Shen Yan, Kangwei Lu, Shixuan Qiu, Xiao Dong Chen, Winston Duo Wu Abstract Based on the drug repositioning strategy, niclosamide (NCL) has shown potential applications for treating COVID-19. However, the development of new formulations for effective NCL delivery is still challenging. Herein, NCL-embedded dry powder… Continue reading Spray freeze dried niclosamide nanocrystals embedded dry powder for high dose pulmonary delivery

Crystal Size Dependence of the Photo-Electrochemical Water Oxidation on Nanoparticulate CaTiO3 Monika Klusáčková, Roman Nebel, Kateřina Minhová Macounová, Petr Krtil Abstract Nanocrystalline CaTiO3 materials with controlled particle size were prepared using spray-freezing/freeze-drying approach utilizing gelatine as a structure-directing agent. The resulting materials show characteristic particle size between 19 and 60 nm. The shape of the nanocrystals… Continue reading Crystal Size Dependence of the Photo-Electrochemical Water Oxidation on Nanoparticulate CaTiO3

Spray Freeze Drying of Biologics: A Review and Applications for Inhalation Delivery Susana Farinha, João V. Sá, Paulo Roque Lino, Marco Galésio, João Pires, Miguel Ângelo Rodrigues, João Henriques Abstract Biopharmaceuticals have established an indisputable presence in the pharmaceutical pipeline, enabling highly specific new therapies. However, manufacturing, isolating, and delivering these highly complex molecules to… Continue reading Spray Freeze Drying of Biologics: A Review and Applications for Inhalation Delivery

Strategies for stabilization and preservation of liposomes Pintu Chowdhary, L. Mahalakshmi, Sayantani Dutta, J.A. Moses, C. Anandharamakrishnan Abstract The stabilization of liposomes is an important aspect for maintaining the integrity of liposome structure. The stability of liposomes reduces in terms of uncontrollable fusion, undesirable payload loss, short shelf life, and unexpected mixing. Additionally, liposomes undergo… Continue reading Strategies for stabilization and preservation of liposomes

Development and performance evaluation of amorphous microencapsules containing lutein nanoparticles via antisolvent precipitation followed by spray/freeze-drying Gang Zhang, Shihong Hu, Xiao Wang, Yanna Zhao, Min Liu, Jun Han, Sangeeta Prakash, Zhengping Wang, Zhuang Ding Summary This study developed nano-sized lutein-loaded solid microcapsules using antisolvent precipitation followed by spray/freeze-drying methods to improve chemical stability and dissolution… Continue reading Development and performance evaluation of amorphous microencapsules containing lutein nanoparticles via antisolvent precipitation followed by spray/freeze-drying

Research Progress and Perspectives of Solid Fuels Chemical Looping Reaction with Fe-Based Oxygen Carriers Yu Guan, Yinhe Liu, Xiaolong Lin, Bo Wang, Qiang Lyu Abstract Chemical looping (CL) is regarded as a promising technology in industrial applications, because of its inherent characteristic of CO2 capture. The technique of CL is applied in solid fuels fields,… Continue reading Research Progress and Perspectives of Solid Fuels Chemical Looping Reaction with Fe-Based Oxygen Carriers

Radio Frequency – Assisted Ultrasonic Spray Freeze Drying for Pharmaceutical Protein Solids Tarun Tejasvi Mutukuri, Ahmad Darwish, Andrew David Strongrich, Dimitrios Peroulis, Alina Alexeenko, Qi (Tony) Zhou Abstract This study examined physical stability of spray freeze dried (SFD) bovine serum albumin (BSA) solids produced using the radio frequency (RF)-assisted drying technique. BSA formulations were prepared… Continue reading Radio Frequency – Assisted Ultrasonic Spray Freeze Drying for Pharmaceutical Protein Solids

Spray-Freeze-Drying of Foods and Bioproducts: Theory, Applications and Perspectives S. Padma Ishwarya Book Description Spray-freeze-drying (SFD) is a synergistic drying technology that imbibes in it the merits of both spray drying and freeze-drying, whilst overcoming the limitations of these predecessor technologies. SFD produces uniquely powdered food and pharmaceutical products with porous microstructure and superior quality… Continue reading Spray-Freeze-Drying of Foods and Bioproducts: Theory, Applications and Perspectives

Rivaroxaban lyospheres prepared by a dimethyl sulfoxide-based spray-freeze-drying process Jan Kožák, Claire Chrétien, Yann Pellequer, Alf Lamprecht Abstract Spray-freeze-drying (SFD) processes are usually using aqueous solvent systems, which however, exclude the use of SFD for poorly water-soluble drugs/excipients. Here, we evaluated dimethyl sulfoxide for its suitability in formulating SFD particles (lyospheres®). Rivaroxaban was spray-freeze-dried from… Continue reading Rivaroxaban lyospheres prepared by a dimethyl sulfoxide-based spray-freeze-drying process

Synthesis of hierarchical ZSM-5 microspheres with superior performance for catalytic methanol-to-olefin conversion Yali Zhang, Kai Zhang, Chao Shang, Xiaoning Wang, Lei Wu, Guoqing Huang, Hao Wang, Qiming Sun, Xiao Dong Chen, Zhangxiong Wu Abstract Methanol-to-olefin (MTO) conversion on zeolites has encountered severe coke deposition and rapid deactivation. Creating different levels of porosity is essential to… Continue reading Synthesis of hierarchical ZSM-5 microspheres with superior performance for catalytic methanol-to-olefin conversion