Freeze Granulation is today being used to process plasma spraying powders for to achieve a homogeneous mixture and spherical granules for improved thermal spraying performance.
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Please contact us and we will further discuss the opportunities with Freeze Granulation on your powder system and read more on technology and we propose a Granulation Test of your powder system.
By using Freeze Granulation, spray freeze drying (SFD), you can produce dry-powder aggregates of thermally sensitive nanoparticles. Dry powder inhaler (DPI) delivery of therapeutic nanoparticles requires the nanoparticles to be transformed into inhalable micro-scale aggregate structures (i.e. nano-aggregates). With Freeze Granulation you will be able to optimize the aerosolization efficiency of the nano-aggregates, while keeping the morphology, production yield, flowability, and aqueous reconstitution in the desirable range.
By applying Freeze Granulation you will be able to make microparticles with high insulin loading (nanosuspension) suitable for needle-free ballistic drug delivery. The resulting granules are homogeneous and robust with a diameter of around 50-150 µm, with a narrow size distribution and a high content of insulin.
Freeze granulation, as opposed to spray drying, has been shown to produce protein particles with light and porous characteristics, which offered powders with superior aerosol performance due to favorable aerodynamic properties, suitable granulation technology for protein inhalation powders.
Freeze Granulation is today used for commercial production of homogeneous granules for the production of oxides used as a ceramic phosphor plate for white illumination in LED Lighting. By using Freeze Granulation of the powder and binder mixture, compared with spray drying, it is possible to manufacture a homogeneous phosphor plate with optimal properties for to generate a soft and warm white light from high power LEDs.
Freeze Granulation can be made using ultrasonic atomisation of the droplets. The resulting granules have a narrow granule size distribution and the granule size is in general smaller (average 120 micron) compared to a regular spray nozzle. The granulation speed is also slow with about 0.3 to 0.5 litre/h.
Freeze Granulation is today beeing used for commercial mixing, granulation and drying of different abrasive products. The resulting products have a homogeneous distribution of all active material, like superabrasive particles, resulting in improved milling performance and long tool life.
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Please contact us and we will further discuss the opportunities with Freeze Granulation on your powder system and read more on technology and we propose a Granulation Test of your powder system.
19-23 June, 2011
Stockholm, Sweden
PowderPro AB thank you for visiting our stand C9 at the Congrss Center in Stockholm!
http://www.ecers2011.se/?type=static&id=1&mo=1
