Category: Scientific papers

Spray freeze drying for protein encapsulation: Impact of the formulation to morphology and stability Alberto Baldelli, Yigong Guo, Hui Xin Ong, Aylin Cidem, Anika Singh, Daniela Traini, Anubhav Pratap-Singh Abstract Proteins, the building blocks of life, are increasingly being used as therapeutics for treating several diseases. Yet, there are challenges in the delivery of highly… Continue reading Spray freeze drying for protein encapsulation: Impact of the formulation to morphology and stability

Modulating the Pore Architecture of Ice-Templated Dextran Microparticles Using Molecular Weight and Concentration Tero Kämäräinen, Kazunori Kadota, Jun Yee Tse, Hiromasa Uchiyama, Shinya Yamanaka, Yuichi Tozuka Abstract Spray freeze drying (SFD) is an ice templating method used to produce highly porous particles with complex pore architectures governed by ice nucleation and growth. SFD particles have… Continue reading Modulating the Pore Architecture of Ice-Templated Dextran Microparticles Using Molecular Weight and Concentration

Spray freeze-drying for inhalation application: process and formulation variables Mostafa Rostamnezhad, Hossein Jafari, Farzad Moradikhah, Sara Bahrainian, Homa Faghihi, Reza Khalvati, Reza Bafkary, Alireza Vatanara Abstract High porous particles with specific aerodynamic properties were processed by the spray freeze-drying (SFD) method. Comprehensive knowledge about all aspects of the SFD method is required for particle engineering… Continue reading Spray freeze-drying for inhalation application: process and formulation variables

Fabricating high-loading ultra-small PtCu3/rGO via a traceless protectant and spray-freeze-drying method Qingyu Luo, Wei Xu, Shaolong Tang Abstract Exploring excellent catalysts for oxygen reduction reaction (ORR) with a facile and cost-effective method is desirable but remains challenging. Herein, ultra-small PtCu3 nanoparticles (ca. 2.7 nm), immobilized on reduced graphene oxide (rGO), were synthesized via a novel and… Continue reading Fabricating high-loading ultra-small PtCu3/rGO via a traceless protectant and spray-freeze-drying method

Designing highly porous amorphous celecoxib particles by spray freeze drying leads to accelerated drug absorption in-vivo Dominic Lucas, Jan Kožák, Annika Rautenberg, Claire Chrétien, Yann Pellequer, Alf Lamprecht Abstract Poorly water-soluble drugs are still a major challenge to overcome in order to achieve sufficiently high oral bioavailability. Spray freeze drying (SFD) is proposed here as… Continue reading Designing highly porous amorphous celecoxib particles by spray freeze drying leads to accelerated drug absorption in-vivo

Dual targeting powder formulation of antiviral agent for customizable nasal and lung deposition profile through single intranasal administration Han Cong Seow, Qiuying Liao, Andy T Y Lau, Susan W S Leung, Shuofeng Yuan, Jenny K W Lam Abstract Unpredictable outbreaks due to respiratory viral infections emphasize the need for new drug delivery strategies to the… Continue reading Dual targeting powder formulation of antiviral agent for customizable nasal and lung deposition profile through single intranasal administration

Encapsulation of probiotics: past, present and future R. Rajam & Parthasarathi Subramanian Abstract – Background Probiotics are live microbial supplements known for its health benefits. Consumption of probiotics reported to improve several health benefits including intestinal flora composition, resistance against pathogens. In the recent years, there is an increasing trend of probiotic-based food products in… Continue reading Encapsulation of probiotics: past, present and future

PRELIMINARY STUDY OF INSULIN DRY POWDER FORMULATION: CRITICAL PROCESS PARAMETERS ON SPRAY-FREEZE-DRYING AND CRITICAL MATERIAL ATTRIBUTES OF TREHALOSE AND INULIN AS STABILIZER CYNTHIA MARISCA MUNTU, SILVIA SURINI, CHRISTINA AVANTI, HAYUN, WOUTER HINRICHS Abstract Objective: The aim of this study was to obtain recommendations about critical process parameters (CPP) and optimal ratio of trehalose and inulin… Continue reading PRELIMINARY STUDY OF INSULIN DRY POWDER FORMULATION: CRITICAL PROCESS PARAMETERS ON SPRAY-FREEZE-DRYING AND CRITICAL MATERIAL ATTRIBUTES OF TREHALOSE AND INULIN AS STABILIZER

Emerging Technologies and Coating Materials for Improved Probiotication in Food Products: a Review Sourav Misra, Pooja Pandey, Chandrakant Genu Dalbhagat, Hari Niwas Mishra Abstract From the past few decades, consumers’ demand for probiotic-based functional and healthy food products is rising exponentially. Encapsulation is an emerging field to protect probiotics from unfavorable conditions and to deliver… Continue reading Emerging Technologies and Coating Materials for Improved Probiotication in Food Products: a Review

Complete Protection Against Yersinia pestis in BALB/c Mouse Model Elicited by Immunization With Inhalable Formulations of rF1-V10 Fusion Protein via Aerosolized Intratracheal Inoculation Wei Zhang, Xiaolin Song, Lina Zhai, Jianshu Guo, Xinying Zheng, Lili Zhang, Meng Lv, Lingfei Hu, Dongsheng Zhou, Xiaolu Xiong and Wenhui Yang Abstract Pneumonic plague, caused by Yersinia pestis, is an… Continue reading Complete Protection Against Yersinia pestis in BALB/c Mouse Model Elicited by Immunization With Inhalable Formulations of rF1-V10 Fusion Protein via Aerosolized Intratracheal Inoculation