Category: Scientific papers

Fabricating high-loading ultra-small PtCu3/rGO via a traceless protectant and spray-freeze-drying method Qingyu Luo, Wei Xu, Shaolong Tang Abstract Exploring excellent catalysts for oxygen reduction reaction (ORR) with a facile and cost-effective method is desirable but remains challenging. Herein, ultra-small PtCu3 nanoparticles (ca. 2.7 nm), immobilized on reduced graphene oxide (rGO), were synthesized via a novel and… Continue reading Fabricating high-loading ultra-small PtCu3/rGO via a traceless protectant and spray-freeze-drying method

Designing highly porous amorphous celecoxib particles by spray freeze drying leads to accelerated drug absorption in-vivo Dominic Lucas, Jan Kožák, Annika Rautenberg, Claire Chrétien, Yann Pellequer, Alf Lamprecht Abstract Poorly water-soluble drugs are still a major challenge to overcome in order to achieve sufficiently high oral bioavailability. Spray freeze drying (SFD) is proposed here as… Continue reading Designing highly porous amorphous celecoxib particles by spray freeze drying leads to accelerated drug absorption in-vivo

Dual targeting powder formulation of antiviral agent for customizable nasal and lung deposition profile through single intranasal administration Han Cong Seow, Qiuying Liao, Andy T Y Lau, Susan W S Leung, Shuofeng Yuan, Jenny K W Lam Abstract Unpredictable outbreaks due to respiratory viral infections emphasize the need for new drug delivery strategies to the… Continue reading Dual targeting powder formulation of antiviral agent for customizable nasal and lung deposition profile through single intranasal administration

Encapsulation of probiotics: past, present and future R. Rajam & Parthasarathi Subramanian Abstract – Background Probiotics are live microbial supplements known for its health benefits. Consumption of probiotics reported to improve several health benefits including intestinal flora composition, resistance against pathogens. In the recent years, there is an increasing trend of probiotic-based food products in… Continue reading Encapsulation of probiotics: past, present and future

PRELIMINARY STUDY OF INSULIN DRY POWDER FORMULATION: CRITICAL PROCESS PARAMETERS ON SPRAY-FREEZE-DRYING AND CRITICAL MATERIAL ATTRIBUTES OF TREHALOSE AND INULIN AS STABILIZER CYNTHIA MARISCA MUNTU, SILVIA SURINI, CHRISTINA AVANTI, HAYUN, WOUTER HINRICHS Abstract Objective: The aim of this study was to obtain recommendations about critical process parameters (CPP) and optimal ratio of trehalose and inulin… Continue reading PRELIMINARY STUDY OF INSULIN DRY POWDER FORMULATION: CRITICAL PROCESS PARAMETERS ON SPRAY-FREEZE-DRYING AND CRITICAL MATERIAL ATTRIBUTES OF TREHALOSE AND INULIN AS STABILIZER

Emerging Technologies and Coating Materials for Improved Probiotication in Food Products: a Review Sourav Misra, Pooja Pandey, Chandrakant Genu Dalbhagat, Hari Niwas Mishra Abstract From the past few decades, consumers’ demand for probiotic-based functional and healthy food products is rising exponentially. Encapsulation is an emerging field to protect probiotics from unfavorable conditions and to deliver… Continue reading Emerging Technologies and Coating Materials for Improved Probiotication in Food Products: a Review

Complete Protection Against Yersinia pestis in BALB/c Mouse Model Elicited by Immunization With Inhalable Formulations of rF1-V10 Fusion Protein via Aerosolized Intratracheal Inoculation Wei Zhang, Xiaolin Song, Lina Zhai, Jianshu Guo, Xinying Zheng, Lili Zhang, Meng Lv, Lingfei Hu, Dongsheng Zhou, Xiaolu Xiong and Wenhui Yang Abstract Pneumonic plague, caused by Yersinia pestis, is an… Continue reading Complete Protection Against Yersinia pestis in BALB/c Mouse Model Elicited by Immunization With Inhalable Formulations of rF1-V10 Fusion Protein via Aerosolized Intratracheal Inoculation

Stability of spouted bed during spray cold coating on the surface of carrier particles Fan Zhang, Linsong Wang, Qing Xu, Wei Tian and Zhanyong Li Abstract The rapid freezing of droplets on the surface of cold carrier particles can reduce the spray freeze-drying time. The coating freezing process can be treated in batch by using… Continue reading Stability of spouted bed during spray cold coating on the surface of carrier particles

Development of drug alone and carrier-based GLP-1 dry powder inhaler formulations Mai Babenko, Raid G. Alany, Gianpiero Calabrese, Waseem Kaialy, Amr ElShaer Abstract The study aimed to develop two types of dry powder inhaler (DPI) formulations containing glucagon-like peptide-1(7–36) amide (GLP-1): carrier-free (drug alone, no excipients) and carrier-based DPI formulations for pulmonary delivery of GLP-1.… Continue reading Development of drug alone and carrier-based GLP-1 dry powder inhaler formulations

Effect of chitosan coating on the properties of nanoliposomes loaded with oyster protein hydrolysates: Stability during spray-drying and freeze-drying Yuyang Ma, Jinjin Xu, Suisui Jiang, Mingyong Zeng Abstract Oyster protein hydrolysate (OPH) has high bioactivity and excellent performance, but its application in food formulation is still limited due to poor flavor and instability. In the… Continue reading Effect of chitosan coating on the properties of nanoliposomes loaded with oyster protein hydrolysates: Stability during spray-drying and freeze-drying