Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by spray-freeze-drying technology Shaofeng Weia, Yueqin Mab, Jing Luoa, Xiaoru Hea, Pengfei Yuea, Zhiyu Guana, Ming Yanga Abstract The objective of this study is to design novel dissolution-enhanced microparticles loaded poorly soluble drug nanocrystals used a low viscosity of hydroxypropylcellulose (HPC) as matrix carrier. An interesting… Continue reading Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by spray-freeze-drying technology
Category: Scientific papers
Additive-free hot-pressed silicon carbide ceramics-A material with exceptional mechanical properties
Additive-free hot-pressed silicon carbide ceramics-A material with exceptional mechanical properties P. Šajgalík, J. Sedláček, Z. Lenčéš, J. Dusza, H.-T. Lin Abstract Densification of silicon carbide without any sintering aids by hot-pressing and rapid hot pressing was investigated. Full density (>99% t.d.) has been reached at 1850 °C, a temperature of at least 150–200 °C lower compared to… Continue reading Additive-free hot-pressed silicon carbide ceramics-A material with exceptional mechanical properties
Dry powder formulation of plasmid DNA and siRNA for inhalation
Dry powder formulation of plasmid DNA and siRNA for inhalation Chow MY, Lam JK Abstract Nucleic acid therapeutics has huge potential for the treatment of a wide range of diseases including respiratory diseases. Plasmid DNA (pDNA) and small interfering RNA (siRNA) are the two most widely investigated nucleic acids for therapeutic development. However, efficient and… Continue reading Dry powder formulation of plasmid DNA and siRNA for inhalation
Dry powder inhaler formulation of high-payload antibiotic nanoparticle complex intended for bronchiectasis therapy: Spray drying versus spray freeze drying preparation
Dry powder inhaler formulation of high-payload antibiotic nanoparticle complex intended for bronchiectasis therapy: Spray drying versus spray freeze drying preparation Yu H, Teo J, Chew JW, Hadinoto K Abstract Inhaled nano-antibiotics have recently emerged as the promising bronchiectasis treatment attributed to the higher and more localized antibiotic exposure generated compared to native antibiotics. Antibiotic nanoparticle… Continue reading Dry powder inhaler formulation of high-payload antibiotic nanoparticle complex intended for bronchiectasis therapy: Spray drying versus spray freeze drying preparation
Spray Freeze-Drying as an Alternative to the Ionic Gelation Method to Produce Chitosan and Alginate Nano-Particles Targeted to the Colon
Spray Freeze-Drying as an Alternative to the Ionic Gelation Method to Produce Chitosan and Alginate Nano-Particles Targeted to the Colon Gamboa A, Araujo V, Caro N, Gotteland M, Abugoch L, Tapia C Abstract Chitosan and alginate nano-composite (NP) carriers intended for colonic delivery containing prednisolone and inulin were obtained by two processes. Spray freeze-drying using… Continue reading Spray Freeze-Drying as an Alternative to the Ionic Gelation Method to Produce Chitosan and Alginate Nano-Particles Targeted to the Colon
Mass production of graphene nanoscrolls and their application in high rate performance supercapacitors
Mass production of graphene nanoscrolls and their application in high rate performance supercapacitors Bingna Zheng, Zhen Xu and Chao Gao The output of graphene nanoscrolls (GNSs) has been greatly enhanced to the gram-level by using an improved spray-freeze-drying method without damaging the high transforming efficiency (>92%). The lowest bulk density of GNS foam reaches 0.10… Continue reading Mass production of graphene nanoscrolls and their application in high rate performance supercapacitors
Production of Inhalation Phage Powders Using Spray Freeze Drying and Spray Drying Techniques for Treatment of Respiratory Infections
Production of Inhalation Phage Powders Using Spray Freeze Drying and Spray Drying Techniques for Treatment of Respiratory Infections Leung SS, Parumasivam T, Gao FG, Carrigy NB, Vehring R, Finlay WH, Morales S, Britton WJ, Kutter E, Chan HK Abstract PURPOSE: The potential of aerosol phage therapy for treating lung infections has been demonstrated in animal… Continue reading Production of Inhalation Phage Powders Using Spray Freeze Drying and Spray Drying Techniques for Treatment of Respiratory Infections
Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders
Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders Maria Malamatari, Satyanarayana Somavarapu, Kevin M.G. Taylor & Graham Buckton Abstract Introduction: Nanosuspensions combine the advantages of nanotherapeutics (e.g. increased dissolution rate and saturation solubility) with ease of commercialisation. Transformation of nanosuspensions to solid oral and inhalable dosage forms minimises… Continue reading Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders
Inhalable nanocomposite microparticles: Preparation, characterization and factors affecting formulation
Inhalable nanocomposite microparticles: Preparation, characterization and factors affecting formulation Elsayed I, AbouGhaly MH Abstract INTRODUCTION: Nanocomposite microparticles are intelligent carriers utilised for pulmonary drug delivery. These carriers are composed of drug-encapsulated nanoparticles dispersed in microstructures of polysaccharides. Upon administration, the inhaled microparticles can penetrate and be deposited deeply in the lung due to their adjusted… Continue reading Inhalable nanocomposite microparticles: Preparation, characterization and factors affecting formulation
Nanoembedded Microparticles for Stabilization and Delivery of Drug-Loaded Nanoparticles
Nanoembedded Microparticles for Stabilization and Delivery of Drug-Loaded Nanoparticles Bohr A, Water J, Beck-Broichsitter M, Yang M Abstract Nanoparticle-based pharmaceutical products are currently finding their way onto the market as a popular strategy to improve the therapeutic efficacy of numerous drugs, hereunder medications for a targeted treatment of severe diseases (e.g., cancer). Drug-loaded polymer and… Continue reading Nanoembedded Microparticles for Stabilization and Delivery of Drug-Loaded Nanoparticles