Freezing behaviour and spray freeze granulation drying of silicon nitride slurries prepared from tert-butyl alcohol and cyclohexane solvent mixtures Riko Yamazaki, Junichi Tatami, Motoyuki Iijima, Shinya Kawaguchi, Naoki Kondo Abstract A spray freeze granulation drying technique is suitable for obtaining soft and homogeneous granules, but the use of an aqueous slurry could degrade raw materials such as nitride. In this study, the freezing behaviour… Continue reading Freezing behaviour and spray freeze granulation drying of silicon nitride slurries prepared from tert-butyl alcohol and cyclohexane solvent mixtures
Category: Scientific papers
Spray freeze-drying for inhalable L-leucine, mannitol-based microparticles: The impact of process variables, L-leucine, and crystallinity on Aerosolization properties
Spray freeze-drying for inhalable L-leucine, mannitol-based microparticles: The impact of process variables, L-leucine, and crystallinity on Aerosolization properties Lorena Pasero, Adamo Sulpizi, Tomaso Guidi, Roberto Pisano Abstract In this study, microparticles carrying salbutamol sulphate were produced by pneumatic spray freeze-drying. The optimal particle size was assessed through a model, associated with a design of experiments. Growing solid concentrations and flow rate led to decreasing geometric diameters, while… Continue reading Spray freeze-drying for inhalable L-leucine, mannitol-based microparticles: The impact of process variables, L-leucine, and crystallinity on Aerosolization properties
Effect of freeze drying and spray drying on physical properties, morphology and in vitro release kinetics of vitamin D3 nanoparticles
Effect of freeze drying and spray drying on physical properties, morphology and in vitro release kinetics of vitamin D3 nanoparticles Iqra Bashir, Sajad Mohd Wani, Auqib Ahmad Bhat, Akhtar Ali Khan, Syed Zameer Hussain, Shaiq Ahmad Ganai, Nadira Anjum Abstract Encapsulation is a viable and effective technique for protection and stability of vitamin D3 during processing. In the present experiment, the effect of ultrasonication on encapsulation of vitamin D3 using… Continue reading Effect of freeze drying and spray drying on physical properties, morphology and in vitro release kinetics of vitamin D3 nanoparticles
Spray freeze drying – A synergistic drying technology and its applications in the food industry to preserve bioactive compounds
Spray freeze drying – A synergistic drying technology and its applications in the food industry to preserve bioactive compounds Nisha Chhabra, Mehak Arora, Diksha Garg, Mahesh Kumar Samota Abstract In the food industry, drying is a crucial unit process for extending product shelf life. Many methods are available for drying of foods but spray drying and freeze drying have been widely adopted… Continue reading Spray freeze drying – A synergistic drying technology and its applications in the food industry to preserve bioactive compounds
Spray freeze drying as a novel drying process for the formulation of probiotic powders containing Lacticaseibacillus rhamnosus GG
Spray freeze drying as a novel drying process for the formulation of probiotic powders containing Lacticaseibacillus rhamnosus GG A. Steegmans, M. Plitzko, B. Luy, S. Lebeer, F. Kiekens Abstract Spray freeze drying was evaluated as a drying process for the formulation and stabilization of probiotic powders This technology combines spray freezing into cold vapour followed by rotational bulk freeze drying, and was investigated to combine the… Continue reading Spray freeze drying as a novel drying process for the formulation of probiotic powders containing Lacticaseibacillus rhamnosus GG
Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying
Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying Koki Ogawa, Otowa Aikawa, Tatsuaki Tagami, Takaaki Ito, Kohei Tahara, Shigeru Kawakami, Tetsuya Ozeki Abstract AbstractA powder formulation for mucosal administration of mRNA-encapsulated lipid nanoparticles (mRNA-LNPs) is expected to be useful for respiratory diseases. Although freeze-drying is widely used to obtain solid formulations of mRNA-LNPs, highly hydrosoluble cryoprotectants, such as sucrose are necessary. However, sucrose is not… Continue reading Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying
Spray freeze dried uniform mannitol microspheres
Spray freeze dried uniform mannitol microspheres Shen Yan, Shengyu Zhang, Xiao Dong Chen, Winston Duo Wu Abstract Spray freeze drying is an attractive technology for fabricating pharmaceutical powder, but it is still challenging to tailor the microparticle physical and chemical structure. Herein, a series of uniform mannitol microparticles with controllable morphology and crystal properties were… Continue reading Spray freeze dried uniform mannitol microspheres
Spray-freeze-drying as emerging and substantial quality enhancement technique in food industry
Spray-freeze-drying as emerging and substantial quality enhancement technique in food industry Poornima Singh, Vinay Kumar Pandey, Rahul Singh, Aamir Hussain Dar Abstract Spray freeze drying is an emerging technology in the food industry with numerous applications. Its ability to preserve food quality, maintain nutritional value, and reduce bulk make it an attractive option to food… Continue reading Spray-freeze-drying as emerging and substantial quality enhancement technique in food industry
Spray Freeze Drying of Biologics: A Review and Applications for Inhalation Delivery
Spray Freeze Drying of Biologics: A Review and Applications for Inhalation Delivery Susana Farinha, João V Sá, Paulo Roque Lino, Marco Galésio, João Pires, Miguel Ângelo Rodrigues, João Henriques Abstract Biopharmaceuticals have established an indisputable presence in the pharmaceutical pipeline, enabling highly specific new therapies. However, manufacturing, isolating, and delivering these highly complex molecules to… Continue reading Spray Freeze Drying of Biologics: A Review and Applications for Inhalation Delivery
Granulation of fine eggshell powder to produce feedstock powder for binder jetting additive manufacturing: A feasibility study
Granulation of fine eggshell powder to produce feedstock powder for binder jetting additive manufacturing: A feasibility study Shakil Arman, Fahim Khan, Mostafa Meraj Pasha, Jackson Sanders, Zhijian Pei Abstract This paper explores the feasibility of granulating fine eggshell powder using spray freeze drying to produce feedstock powder for binder jetting additive manufacturing. Fine eggshell powder possesses carbon-capture potential but exhibits poor flowability, causing issues during powder spreading in binder jetting additive… Continue reading Granulation of fine eggshell powder to produce feedstock powder for binder jetting additive manufacturing: A feasibility study