Ch. Niranjan Patra*, Supriyo Satapathy, Shuvendu K Dinda, Sudarsan Behera, Sashank S Hota, Goutam K Jena and Sanjiv K Panda
Abstract
Granulation, a cornerstone process in many industries, has seen significant advancements in recent years. This abstract explores these novel techniques, highlighting their potential to improve the functionality and efficiency of granule production.The traditional wet and dry granulation methods are addr essed, outlining their limitations, such as solvent usage and challenges with moisturesensitive materials. The abstract then delves into innovative approaches that address these limitations. Techniques like pneumatic granulation, reverse granulation, foam granulation, steam granulation, and moisture-activated dry granulation (MADG) are discussed, emphasizing their advantages. Foam granulation offers improved binder distribution and reduced water requirement, while steam granulation eliminates organic solvents and promotes faster drying. Improved granule properties, including folowability, compressibility, and controlled release characteristics, are highlighted. Additionally, the reduction of solvent usage and drying times translates to increased environmental sustainability and production efficiency.The abstract concludes by emphasizing the ongoing development of novel granulation techniques. It underscores the potential of these advancements to revolutionize various industrial processes, particularly in the pharmaceutical industries, by ensuring the production of high-quality granules with improved functionality and at a reduced environmental cost.
Keywords:
moisture-activated dry granulation, freeze-drying