Category: Scientific papers

Dense and homogeneous MOX fuel pellets manufactured using the freeze granulation route F. La Lumia, L. Ramond, C. Pagnoux, P. Coste Abstract MOX fuels (UO2‐PuO2) are used in light water nuclear reactors of several countries and are also potential candidates for fast neutron reactors. Industrial MOX is currently manufactured by a dry‐route process, involving steps… Continue reading Dense and homogeneous MOX fuel pellets manufactured using the freeze granulation route

Rapid freezing using atomized liquid nitrogen spray followed by frozen storage below glass transition temperature for Cordyceps sinensis preservation: Quality attributes and storage stability You Tian, Dongmei Li, Wenhuang Luo, Zhiwei Zhu, Wenjia Li, Zhengming Qian, Guangrong Li, Da-Wen Sun Abstract Fresh Cordyceps sinensis (CS) is rich in bioactive components but perishable with a short… Continue reading Rapid freezing using atomized liquid nitrogen spray followed by frozen storage below glass transition temperature for Cordyceps sinensis preservation: Quality attributes and storage stability

Binder Jetting Additive Manufacturing of Ceramics: Comparison of Flowability and Sinterability Between Raw and Granulated Powders Wenchao Du, Guanxiong Miao, Lianlian Liu, Zhijian Pei, Chao Ma Abstract The objective of this study is to compare three different feedstock powders for the binder jetting process by characterizing their flowability and sinterability. Binder jetting additive manufacturing is… Continue reading Binder Jetting Additive Manufacturing of Ceramics: Comparison of Flowability and Sinterability Between Raw and Granulated Powders

Binder Jetting Additive Manufacturing of Ceramics: Feedstock Powder Preparation by Spray Freeze Granulation Wenchao Du, Guanxiong Miao, Lianlian Liu, Zhijian Pei Abstract Objective of this study is to prepare the binder jetting feedstock powder by spray freeze drying and study the effects of its parameters on the powder properties. Binder jetting additive manufacturing is a… Continue reading Binder Jetting Additive Manufacturing of Ceramics: Feedstock Powder Preparation by Spray Freeze Granulation

Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections Shihui Yu, Shaoning Wang, Peizhi Zou, Guihong Chai, Yu-Wei Lin, Tony Velkov, Jian Li, Weisan Pan, Qi Tony Zhou Abstract The aim of this study was to design and characterize dry powder inhaler formulations of ciprofloxacin and colistin… Continue reading Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections

Naked pDNA/hyaluronic acid powder shows excellent long-term storage stability and gene expression in murine lungs Takaaki Ito, Maino Fukuhara, Tomoyuki Okuda, Hirokazu Okamoto Abstract We evaluated the storage stability of powder containing naked plasmid DNA (pDNA) and hyaluronic acid (HA) or mannitol (Man) prepared by the spray-freeze-drying technique, through which we have reported high gene… Continue reading Naked pDNA/hyaluronic acid powder shows excellent long-term storage stability and gene expression in murine lungs

Effects of liquid nitrogen quick freezing on polyphenol oxidase and peroxide activities, cell water states and epidermal microstructure of wolfberry ZhiweiZhu, Wenhuang Lou, Da-Wen Sun Abstract Fresh wolfberry has a very short shelf-life and drying is the most common method for preserving wolfberry. For better retention of the quality and nutritional values of wolfberry, effects… Continue reading Effects of liquid nitrogen quick freezing on polyphenol oxidase and peroxide activities, cell water states and epidermal microstructure of wolfberry

Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide Abstract Pulmonary delivery of messenger RNA (mRNA) has considerable potential as therapy or vaccine for a range of lung diseases. Inhaled dry powder formulation of mRNA is particularly attractive as it has superior stability and dry powder inhaler is relatively easy to… Continue reading Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

Effect of Particle Formation Process on Characteristics and Aerosol Performance of Respirable Protein Powders Brunaugh AD, Wu T, Kanapuram SR, Smyth HDC Abstract Pulmonary delivery of biopharmaceuticals may enable targeted local therapeutic effect and noninvasive systemic administration. Dry powder inhaler (DPI) delivery is an established patient-friendly approach for delivering large molecules to the lungs; however,… Continue reading Effect of Particle Formation Process on Characteristics and Aerosol Performance of Respirable Protein Powders.

A spray freeze dried micropellet based formulation proof-of-concept for a yellow fever vaccine candidate Clénet D, Hourquet V, Woinet B, Ponceblanc H, Vangelisti M Abstract The stability of live-attenuated viruses is very challenging due to thermal sensitivity; therefore, solid form is usually required (often freeze-dried products). Micropellet technology is a lyophilization technology that has the… Continue reading A spray freeze dried micropellet based formulation proof-of-concept for a yellow fever vaccine candidate