Category: Scientific papers

Formulation and optimization of sildenafil citrate-loaded PLGA large porous microparticles using spray freeze-drying technique: A factorial design and in-vivo pharmacokinetic study Hend Shahin, Bhavani Prasad Vinjamuri, Azza A.Mahmoud, Suzan M.Mansour, Mahavir Bhupal Chougule, Lipika Chablani Abstract The oral administration of sildenafil citrate (SC) for the treatment of pulmonary arterial hypertension is associated with several drawbacks.… Continue reading Formulation and optimization of sildenafil citrate-loaded PLGA large porous microparticles using spray freeze-drying technique: A factorial design and in-vivo pharmacokinetic study

The application of freeze-drying as a production method of drug nanocrystals and solid dispersions – A review Emilia Jakubowska, Janina Lulek Abstract This work reviews the examples of the application of lyophilization and its cryogenic modifications as the production method of solid dispersions and drug nanocrystals, two formulation approaches aimed at increasing the solubility, dissolution… Continue reading The application of freeze-drying as a production method of drug nanocrystals and solid dispersions – A review

Influence of three types of freezing methods on physicochemical properties and digestibility of starch in frozen unfermented dough Yong Yang, Shuaishuai Zheng, Zhen Li, Zhili Pan, Zhongmin Huang, Jianzhong Zhao, Zhilu Ai Abstract Three types of freezing methods, namely, spiral tunnel freezing method (SF), cryogenic refrigerator freezing method (RF) and liquid nitrogen spray freezing method… Continue reading Influence of three types of freezing methods on physicochemical properties and digestibility of starch in frozen unfermented dough

Effect of Ca2+ and Mg2+ ions on the sintering and spectroscopic properties of cr‐doped yttrium aluminum garnet ceramics Przemysław Gołębiewski, Helena Węglarz, Magdalena Nakielska, Anna Wajler Abstract In this work, we investigated the effects of Ca2+ and Mg2+ ions and annealing temperature on the spectroscopic parameters of chromium‐doped yttrium aluminum garnet ceramics (Cr:YAG). Samples were… Continue reading Effect of Ca2+ and Mg2+ ions on the sintering and spectroscopic properties of cr‐doped yttrium aluminum garnet ceramics

Formulation and evaluation of inhalable microparticles of Rizatriptan Benzoate processed by spray freeze-drying Mahsa Keyhan shokouh, Homa Faghihi, Majid Darabi, Maryam Mirmoeini, Alireza Vatanara Abstract The aim of the current study was to prepare and evaluate inhalable microparticles of Rizatriptan benzoate in order to further benefit from its pulmonary delivery, the expected enhanced bioavailability and… Continue reading Formulation and evaluation of inhalable microparticles of Rizatriptan Benzoate processed by spray freeze-drying

Engendering Unprecedented Activation of Oxygen Evolution via Rational Pinning of Ni Oxidation State in Prototypical Perovskite: Close Juxtaposition of Synthetic Approach and Theoretical Conception Rebecca Pittkowski, Spyridon Divanis, Mariana Klementová, Roman Nebel, Shahin Nikman, Harry Hoster, Sanjeev Mukerjee, Jan Rossmeisl, Petr Krtil Abstract Rational optimization of the OER activity of catalysts based on LaNiO3 oxide… Continue reading Engendering Unprecedented Activation of Oxygen Evolution via Rational Pinning of Ni Oxidation State in Prototypical Perovskite: Close Juxtaposition of Synthetic Approach and Theoretical Conception

Particle Size Reduction Techniques of Pharmaceutical Compounds for the Enhancement of Their Dissolution Rate and Bioavailability Rahul Kumar, Amit K. Thakur, Pranava Chaudhari, Nilanjana Banerjee Abstract In pharmaceutical research and development, various new chemical entities (NCE) are found to be poorly water-soluble. Therefore, solubility enhancement, a key factor for higher bioavailability, is a major challenge… Continue reading Particle Size Reduction Techniques of Pharmaceutical Compounds for the Enhancement of Their Dissolution Rate and Bioavailability

Effects of drying method and excipient on the structure and physical stability of protein solids: Freeze drying vs. spray freeze drying Tarun Tejasvi Mutukuri, Nathan E. Wilson, Lynne S. Taylor, Elizabeth M. Topp, Qi Tony Zhou Abstract This study aims to determine the impacts of drying method and excipient on changes in protein structure and… Continue reading Effects of drying method and excipient on the structure and physical stability of protein solids: Freeze drying vs. spray freeze drying

A Kinetic Model for Spray-Freezing of Pharmaceuticals Abstract Spray freeze-drying (SFD), which includes spray-freezing into droplets and dynamic vacuum drying, presents a promising alternative approach to manufacture dried pharmaceuticals more efficiently than conventional vial freeze-drying. Without reliable predictive models for the SFD conditions of interest, any respective process development still relies on empirical approaches. In… Continue reading A Kinetic Model for Spray-Freezing of Pharmaceuticals

Transparent cobalt‐doped yttrium aluminum garnet (Co2+:YAG) ceramics—An innovatory fast saturable absorber Agnieszka Szysiak, Kamila Leśniewska‐Matys, Helena Węglarz, Przemysław Gołębiewski, Dariusz Podniesiński, Anna Kozłowska Abstract Highly transparent Y3Al5O12 (YAG) ceramics doped with 0.025 and 0.05 at.% Co ions were prepared for the first time by the freeze granulation process and reaction sintering. Scanning electron microscopy (SEM)… Continue reading Transparent cobalt‐doped yttrium aluminum garnet (Co2+:YAG) ceramics—An innovatory fast saturable absorber