Microstructure of spray freezing dried powders affected by the presence of inert particles

Microstructure of spray freezing dried powders affected by the presence of inert particles

Fan Zhang, Linsong Wang, Xiaoyu Ma, Qing Xu, Wei Tian, Zhanyong li

Abstract

Spray freeze-drying is a process to directly produce high quality powders with short drying time. The difference of microstructures has a great influence on the physical properties of powders. However, during the spray freeze-drying process, the freezing degree of droplets in the drying chamber will change the product structure and affect the powder quality. In this study, the surface structure and morphology of dry powders were observed using scanning electron microscopy. The formation mechanism of droplet morphology during spray freeze-drying was analyzed. The results show that the rapid freezing process can produce finer microstructures.