Category: Scientific papers

Aerodynamic Droplet Stream Expansion for the Production of Spray Freeze-Dried Powders Wanning S, Süverkrüp R, Lamprecht A Abstract In spray freeze-srying (SFD), a solution is sprayed into a refrigerant medium, frozen, and subsequently sublimation dried, which allows the production of flowable lyophilized powders. SFD allows commonly freeze-dried active pharmaceutical ingredients (e.g., proteins and peptides) to… Continue reading Aerodynamic Droplet Stream Expansion for the Production of Spray Freeze-Dried Powders

Aerosol assisted self-assembly as a route to synthesize solid and hollow spherical lignin colloids and its utilization in layer by layer deposition Mishra PK, Wimmer R Abstract Lignin, a major constituent of plant cell-wall and by-product of paper based industries is traditionally used for low value applications (heat or electricity generation), but its potential in… Continue reading Aerosol assisted self-assembly as a route to synthesize solid and hollow spherical lignin colloids and its utilization in layer by layer deposition

Spray freeze drying as an alternative technique for lyophilization of polymeric and lipid-based nanoparticles Mohamed Ehab Alia, Alf Lamprechta Abstract The use of nanoparticles for drug delivery is still restricted by their limited stability when stored in an aqueous medium. Freeze drying is the standard method for long-term storage of colloidal nanoparticles; however the method… Continue reading Spray freeze drying as an alternative technique for lyophilization of polymeric and lipid-based nanoparticles

Improved transparency and hardness in α-alumina ceramics fabricated by high-pressure SPS of nanopowders Shaghayegh Ghanizadeha, Salvatore Grassob, Prabhu Ramanujamc, Bala Vaidhyanathana, Jon Binnerc, Peter Brownd, Judah Goldwassere Abstract Nanocrystalline alumina powder with an average crystallite size of ≤50 nm has been consolidated by spark plasma sintering (SPS) and hot pressing (HP) with a view to… Continue reading Improved transparency and hardness in α-alumina ceramics fabricated by high-pressure SPS of nanopowders

Effect of cryogenic freezing by liquid nitrogen on the quality and microstructure of Portunus trituberculatus Hori T, Odaka S, Oba H, Mizutani T, Kawakami E, Tsutsui T. Abstract The freezing conditions for preparation of frozen canine semen by the plunging method were investigated with regard to the period of sensitization in liquid nitrogen (LN2) vapor… Continue reading Effect of cryogenic freezing by liquid nitrogen on the quality and microstructure of Portunus trituberculatus

Atmospheric Spray Freeze-Drying: Numerical Modeling and Comparison With Experimental Measurements Israel Borges Sebastião, Thomas D. Robinson, Alina Alexeenko Abstract Atmospheric spray freeze-drying (ASFD) represents a novel approach to dry thermosensitive solutions via sublimation. Tests conducted with a second-generation ASFD equipment, developed for pharmaceutical applications, have focused initially on producing a light, fine, high-grade powder consistently… Continue reading Atmospheric Spray Freeze-Drying: Numerical Modeling and Comparison With Experimental Measurements

Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by spray-freeze-drying technology Shaofeng Weia, Yueqin Mab, Jing Luoa, Xiaoru Hea, Pengfei Yuea, Zhiyu Guana, Ming Yanga Abstract The objective of this study is to design novel dissolution-enhanced microparticles loaded poorly soluble drug nanocrystals used a low viscosity of hydroxypropylcellulose (HPC) as matrix carrier. An interesting… Continue reading Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by spray-freeze-drying technology