An Innovative Formulation Development Approach of Sustained Release Matrix Tablet: A Review

An Innovative Formulation Development Approach of Sustained Release Matrix Tablet: A Review

S Gokulakrishnan, K B Ilango, R Kalyan, R Samyuktha, A Subash, K Subhashini

Abstract

This review delves about the various manufacturing process/ method of the sustained release matrix tablet & the methods are direct compression, wet granulation, dry granulation, foam granulation, freeze granulation, nanosponge, sintering method, 3D Printing. These all method possesses distinctive traits & unique benefits. The choice of process depends upon the specific formulation, desired tablet characteristic and production scale. In these methods, the solid medicaments are distributed throughout the porous matrix formed by the polymer which controls the medicament releasing & there is a presence of a novel strategy for prolonging drug release is the disintegration-controlled matrix, which maintains release for up to 24 hours by regulating the tablets breakdown rate. This review also discusses about the formulation of sustained release matrix tablet by using Quality by Design (QbD) & their dissolution patterns is indirectly detected by using the AI tool. Keywords: Sintering, Nano sponge, 3-D Printing, DCMT (Disintegration Controlled Matrix Tablet), Sustained-Release, Artificial intelligence.

Keywords:

Freeze granulation, dry granulation, foam granulation, wet granulation, nanosponge