SPRAY FREEZE DRYING FORMATION OF DRY POWDER COMPOSITIONS

SPRAY FREEZE DRYING FORMATION OF DRY POWDER COMPOSITIONS

Inventors:
BUCKLAND, Justin
CHATURBEDY, Piyush
TAYLOR, Steve
WENBAN, Nathan
COUPLAND, George

Abstract

The present invention relates to dry powder compositions, methods, apparatus and systems for manufacture of the same. In particular, the present invention relates to a system for producing a dry powder composition including a vacuum chamber depressurised by a vacuum pump and a spray head assembly configured to introduce a liquid formulation into the vacuum chamber, wherein the spray head assembly is ultrasonically stimulated during introduction of the liquid formulation into the vacuum chamber to initiate breakup of the liquid formulation into liquid droplets within the vacuum chamber. The present invention further relates to dry powder compositions comprising lyophilised aggregates produced with such apparatus.